In Italy, most of the residential buildings were constructed before 1981, when only 25% of the national territory was classified as seismic; the larger proportion of this building stock is Reinforced Concrete (RC) structures. These building designed only to resist to gravity load, shows several structural deficiencies under seismic action related both to the lack local details (e.g. absence of transverse reinforcement in beam-column joints) and poor structural material properties. The vulnerability of existing buildings designed without seismic arrangements was highlighted by recent earthquake that caused damage and several buildings collapse. Nowadays, the rehabilitation of existing structures, taking into account energetic and sustainability requirements, is a newsworthy and challenging task. In this work, the seismic performances of an existing, gravity load designed, RC frame residential building located in Mugnano di Napoli (NA, Italy) were investigated. First, the assessment of the existing structure's performance in a code-based approach was performed; then, a strengthening intervention by means of Orthogonal Steel Exoskeleton system was designed through a detailed step-by-step procedure. The efficiency of the proposed global strengthening intervention were assessed by means of a non-linear static analyses. Designed interventions allows to strongly increase the structural performance of the investigated case study.