The build-up of earthquake-induced excess pore-water pressure may be viewed as analogous to the cumulative damage of saturated granular materials caused by cyclic loading, and consequently as a damage metric when converting an irregular earthquake loading to an equivalent number of uniform cycles, Neq. In this paper, a comprehensive series of strain-controlled tests have been conducted using the new combined triaxial simple shear (TxSS) apparatus developed at Institute de Recherche d’Hydro-Quebec (IREQ) in collaboration with the geotechnical group at the Université de Sherbrooke to verify the hypothesis of adopting the pore-water pressure ratio, Ru, as a damage metric when converting earthquakes to an equivalently damaging number of uniform strain cycles. Different reconstituted saturated samples of Baie-Saint-Paul, Carignon, and Quebec sands have been tested under undrained conditions up to liquefaction. The experimental results from this study have been utilized to develop an empirical expression to compute Neqγ from both the number of cycles required to trigger liquefaction, Nliq, and the material parameter, r. The parameter r had been experimentally calibrated a priori from a separate set of tests using uniform strain cycles following the theoretical framework outlined by Green and Lee in 2006. The present results reveal that the measured pore-water pressure ratio, Ru, is in agreement with predicted cumulative damage using the Richart and Newmark (R–N) hypothesis. However, the Palmgren–Miner (P–M) hypothesis underestimates the cumulative damage (i.e., the generated pore-water pressure) during cyclic loading.