A simulation model for studies of intestine cell dynamics

Meinzer, Hans-Peter; Sandblad, Bengt

doi:10.1016/0169-2607(85)90067-7

Cited by 15 publications

(16 citation statements)

References 53 publications

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“…All new daughter cells are arranged on top of each other and the rest of the column then moves one cell position upwards. This model is basically similar to one examined by Meinzer & Sandblad (1985).…”

Section: Model a (Only Verlical Displacement Of Newborn Cells)supporting

confidence: 70%

Intestinal Crypt Proliferation. Ii. Computer Modelling of Mitotic Index Data Provides Further Evidence For Lateral and Vertical Cell Migration In the Absence of Mitotic Activity

Loeffler

Potten

Paulus³

et al. 1988

Cell Proliferation

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Abstract. The position‐dependent mitotic index before, and 1, 2 and 3 h after vincristine was scored. the accumulation of cells in mitosis leads to an increase in the mitotic index from 0.06 to 0.34 at crypt positions 8‐12. Surprisingly, the leading edge of the position‐related mitotic index distribution moves to higher crypt positions although cell division was stopped. In addition, the vertical clustering of mitotic figures in sections was recorded. the data were examined using a previously described computer crypt model. We conclude: the average mitotic phase duration is about 0.7 h (40 min) and varies little with cell position; the geometrical correction factor for overscoring mitoses in crypt sections is about 0.6‐0.7 and adjacent cell columns can merge. Lateral cell displacement after mitosis, as predicted in a previous model analysis, would be a mechanism to counteract other forces that tend to reduce the crypt circumference. In the normal steady state merging and expansion processes would just balance each other. This would not follow if one mechanism was blocked. Thus we propose a new concept in which the crypt geometry would be dynamically determined by cell proliferative activity in connection with lateral positioning of new cells on one hand and contracting forces on the other hand.

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Section: Model a (Only Verlical Displacement Of Newborn Cells)supporting

confidence: 70%

Intestinal Crypt Proliferation. Ii. Computer Modelling of Mitotic Index Data Provides Further Evidence For Lateral and Vertical Cell Migration In the Absence of Mitotic Activity

Loeffler

Potten

Paulus³

et al. 1988

Cell Proliferation

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“…This influences especially the mitotic index in the lower five to ten positions. A more comprehensive description of the simulation model is published elsewhere (Meinzer & Sandblad, 1985). Figures 2 , 4 and 5 support our generation hypothesis.…”

Section: O "supporting

confidence: 66%

“…The dynamic simulation model for the basic crypt cell kinetics, which we have developed, has been presented in detail (Meinzer et af., 1983;Meinzer & Sandblad, 1985). The model is based…”

Section: T H E M O D E Lmentioning

confidence: 99%

Evidence For Cell Generation Controlled Proliferation In the Small Intestinal Crypt

Meinzer

Sandblad²

1986

Cell Proliferation

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Abstract. In this paper we discuss the hypothesis that cell proliferation is controlled by the number of generations after leaving an ‘eternal’ stem cell. the theory is based on a simulation of the kinetic behaviour of cells in the intestinal crypts. There is evidence of three, four and five generations of cells which are allowed to enter mitosis in the lower and upper part of the normal intestinal tract, and in some disease states, respectively. We suggest an internal proliferation control: some kind of knowledge that cells carry from generation to generation. It is an open question what sets and changes the generation counter: internal genetic information or external influences such as growth factors or chalones. The geometric shape of the epithelial tissue in the intestinal tract can be understood as the steady state of a highly dynamic process. Age and death are determined from the beginning; cell‐cell interaction or communication is not necessary and can be neglected. Our theory will be illustrated using the intestinal crypts as they are easily accessible, of a simple structure and completely described in the literature.

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“…These rules are then incorporated into models to determine whether the hypothesized behavior can explain the complicated dynamics seen in the experimental data obtained by Al-Dewachi et al (2). Spatial modeling (3)(4)(5)(6)(7)(8)(9) has shown that cells in different parts of the crypt follow different rules for proliferation. Since this nonhomogeneity in cell response may play an important role in how the tissue regrows, we have also allowed for a variation in response to ara-C in the crypt and have represented the system with an event-oriented (rule-based) spatial model.…”

Section: Introductionmentioning

confidence: 98%

Applying Computer Modeling to Examine Complex Dynamics and Pattern Formation of Tissue Growth

Isele

Meinzer

1998

Computers and Biomedical Research

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A simulation model for studies of intestine cell dynamics

Cited by 15 publications

References 53 publications

Intestinal Crypt Proliferation. Ii. Computer Modelling of Mitotic Index Data Provides Further Evidence For Lateral and Vertical Cell Migration In the Absence of Mitotic Activity

Intestinal Crypt Proliferation. Ii. Computer Modelling of Mitotic Index Data Provides Further Evidence For Lateral and Vertical Cell Migration In the Absence of Mitotic Activity

Evidence For Cell Generation Controlled Proliferation In the Small Intestinal Crypt

Applying Computer Modeling to Examine Complex Dynamics and Pattern Formation of Tissue Growth

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