A single arm trial using passive simulated jogging for blunting acute hyperglycemia

Adams, José A.; López, José R.; Banderas, Veronica; Sackner, Marvin A.

doi:10.1038/s41598-021-85579-7

Cited by 8 publications

(13 citation statements)

References 49 publications

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“…Hyperglycemia (HG) is common in patients suffering from cardiovascular diseases [17], is an established independent predictor of severe outcomes, even in absence of frank dia-betes mellitus (DM) [18,19], and has been proposed to exacerbate endothelial dysfunction in hypertensive subjects [20][21][22][23][24][25][26][27][28][29][30][31][32].…”

Section: Introductionmentioning

confidence: 99%

Cognitive Impairment in Frail Hypertensive Elderly Patients: Role of Hyperglycemia

Mone

Gambardella

Pansini

et al. 2021

Cells

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Endothelial dysfunction is a key hallmark of hypertension, which is a leading risk factor for cognitive decline in older adults with or without frailty. Similarly, hyperglycemia is known to impair endothelial function and is a predictor of severe cardiovascular outcomes, independent of the presence of diabetes. On these grounds, we designed a study to assess the effects of high-glucose and metformin on brain microvascular endothelial cells (ECs) and on cognitive impairment in frail hypertensive patients. We tested the effects of metformin on high-glucose-induced cell death, cell permeability, and generation of reactive oxygen species in vitro, in human brain microvascular ECs. To investigate the consequences of hyperglycemia and metformin in the clinical scenario, we recruited frail hypertensive patients and we evaluated their Montreal Cognitive Assessment (MoCA) scores, comparing them according to the glycemic status (normoglycemic vs. hyperglycemic) and the use of metformin. We enrolled 376 patients, of which 209 successfully completed the study. We observed a significant correlation between MoCA score and glycemia. We found that hyperglycemic patients treated with metformin had a significantly better MoCA score than hyperglycemic patients treated with insulin (18.32 ± 3.9 vs. 14.94 ± 3.8; p < 0.001). Our in vitro assays confirmed the beneficial effects of metformin on human brain microvascular ECs. To our knowledge, this is the first study correlating MoCA score and glycemia in frail and hypertensive older adults, showing that hyperglycemia aggravates cognitive impairment.

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Section: Introductionmentioning

confidence: 99%

Cognitive Impairment in Frail Hypertensive Elderly Patients: Role of Hyperglycemia

Mone

Gambardella

Pansini

et al. 2021

Cells

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“…Then began the exercise load test. 4 The subject pedaled a bicycle to enter the exercise load experiment. Male pedaling load power is five levels (50W, 75W, 100W, 125W, 150W), female and obese group pedaling load power is 4 levels (50W, 75W, 100W, 125W).…”

Section: Experimental Methodsmentioning

confidence: 99%

High-Intensity Training on Pulse and Dicrotic Waveform in Chronic Diseases

Teng

Chen

et al. 2021

Rev Bras Med Esporte

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Introduction: The formation and propagation of pulse waves are mainly accomplished by coordinating the heart and the vascular system. The contraction and relaxation of the heart are the sources of pulse waves. The aorta vibrates regularly as the heart contracts. This vibration propagates forward along the elastic blood vessel to form a pulse wave. The pulse wave contains very rich physiological and pathological information about the cardiovascular system. If there is a problem with the heart's structure, it can cause abnormal pulse waveforms. Objective: This article analyzes pulse waveform changes and blood flow during high-intensity interval training. It combines the test results to guide the exercise rehabilitation treatment of patients with chronic diseases. Methods: Pulse waves were collected from subjects under different exercise loads and the characteristics of pulse wave parameters under intermittent exercise were studied. Results: An athlete's pulse wave response is different in the case of high-intensity intermittent exercise. There are differences in the cardiovascular response of patients with different body weights. Conclusion: High-intensity interval training can improve the cardiovascular function of patients with chronic diseases and affect their pulse waveform. Level of evidence II; Therapeutic studies - investigation of treatment results.

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“…During a training cycle, the medial thigh, vastus medialis, rectus femoris, vastus lateralis, and semimembranosus semitendinosus were activated at a frequency of 1 time each. 8 The frequency of activation of the biceps femoris and the medial head of the gastrocnemius was two times. The anterior tibialis muscle, on the other hand, is often active.…”

Section: Changes In Muscle Performancementioning

confidence: 96%

Restorative Effect of Jogging on Lower Limb Muscles

Zhang¹,

Chen

2023

Rev Bras Med Esporte

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Introduction: Jogging can be a great way to improve physical condition, boosting mind and body. Its method of movement is simple, and there are no sporting limitations as to age, gender, or training place. Jogging is believed to help repair muscle and joint injuries in the lower limbs. Objective: To explore the effects of running on recovering lower limb muscles. Methods: We surveyed 60 undergraduate students who took a 400-meter test at the same site. According to the test results, they were divided into low, medium, and high fitness levels. A questionnaire survey was also used with 20 undergraduate students from the Physical Education Department. Four groups of volunteers did some jogging exercises. Physiological, biochemical, and muscle strength measurements were performed after jogging. The data were statistically treated. Results: The magnitude of change in the sagittal angle of the knee and ankle joint did not increase significantly with increasing jogging rate. The changes in the sagittal angles of the hip, knee, and ankle joints were the same for the volunteers with different jogging rates. After 60 minutes of exercise, the low-fitness group showed faster breathing, an elevated heart rate, and a higher rate of lactate and creatinine in the blood. After 120 minutes of exercise training, all sedentary volunteers showed an increase in lactate, creatinine, respiratory rate, and heart rate (P<0.05). The test performance started to decrease at 400 meters. Conclusion: The maximal activation of different parts of the locomotor system changed under different rates of movement. Brief, controlled jogging may be beneficial to lower limb muscles. Still, long-term jogging may cause even more damage to the body and deleterious changes to rehabilitation in blood and biochemical parameters. Level of evidence II; Therapeutic studies - investigation of treatment outcomes.

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A single arm trial using passive simulated jogging for blunting acute hyperglycemia

Cited by 8 publications

References 49 publications

Cognitive Impairment in Frail Hypertensive Elderly Patients: Role of Hyperglycemia

Cognitive Impairment in Frail Hypertensive Elderly Patients: Role of Hyperglycemia

High-Intensity Training on Pulse and Dicrotic Waveform in Chronic Diseases

Restorative Effect of Jogging on Lower Limb Muscles

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