A Single Bout of High-Intensity Interval Training Improves Motor Skill Retention in Individuals With Stroke

Nepveu, Jean-François; Thiel, Alexander; Tang, Ada; Fung, Joyce; Lundbye‐Jensen, Jesper; Boyd, Lara A.; Roig, Marc

doi:10.1177/1545968317718269

Cited by 87 publications

(173 citation statements)

References 62 publications

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“…, b, ; Nepveu et al . ). First, in all previous studies, the task was either a visuomotor tracking task or time‐on‐target motor task.…”

Section: Discussionmentioning

confidence: 97%

“…, b; Nepveu et al . ). Learning a simple task that requires few effectors and little to no challenge to postural stability is quite different from learning a task that requires motor control of multiple effectors to accomplish a complex movement with significant postural stability challenges, such as walking.…”

Section: Discussionmentioning

confidence: 97%

“…The research in this area is limited, however, with only one study recently investigating the effect of high‐intensity exercise on motor learning after stroke (Nepveu et al . ). The task (i.e.…”

Section: Introductionmentioning

confidence: 97%

“…Compared to the subjects in the ‘no exercise’ group, those who exercised at high intensities after the motor practice, had greater retention of the motor task 24 h later (Nepveu et al . ). This is the first evidence that a single high‐intensity exercise bout can improve retention of an upper extremity motor skill task after stroke.…”

Section: Introductionmentioning

confidence: 97%

“…, b, ; Nepveu et al . ). This type of motor learning task requires limited motor control across joints or limbs and may rely heavily on a strategy‐based form of learning (Taylor & Ivry, ; Haith & Krakauer, ).…”

Section: Introductionmentioning

confidence: 97%

See 4 more Smart Citations

A single exercise bout and locomotor learning after stroke: physiological, behavioural, and computational outcomes

Charalambous

Alcântara

French

et al. 2018

The Journal of Physiology

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Acute high-intensity exercise coupled with motor practice improves the retention of motor learning in neurologically intact adults. However, whether exercise could improve the retention of locomotor learning after stroke is still unknown. Here, we investigated the effect of exercise intensity and timing on the retention of a novel locomotor learning task (i.e. split-belt treadmill walking) after stroke. Thirty-seven people post stroke participated in two sessions, 24 h apart, and were allocated to active control (CON), treadmill walking (TMW), or total body exercise on a cycle ergometer (TBE). In session 1, all groups exercised for a short bout (∼5 min) at low (CON) or high (TMW and TBE) intensity and before (CON and TMW) or after (TBE) the locomotor learning task. In both sessions, the locomotor learning task was to walk on a split-belt treadmill in a 2:1 speed ratio (100% and 50% fast-comfortable walking speed) for 15 min. To test the effect of exercise on 24 h retention, we applied behavioural and computational analyses. Behavioural data showed that neither high-intensity group showed greater 24 h retention compared to CON, and computational data showed that 24 h retention was attributable to a slow learning process for sensorimotor adaptation. Our findings demonstrated that acute exercise coupled with a locomotor adaptation task, regardless of its intensity and timing, does not improve retention of the novel locomotor task after stroke. We postulate that exercise effects on motor learning may be context specific (e.g. type of motor learning and/or task) and interact with the presence of genetic variant (BDNF Val66Met).

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“…, b, ; Nepveu et al . ). First, in all previous studies, the task was either a visuomotor tracking task or time‐on‐target motor task.…”

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 97%

See 3 more Smart Citations

A single exercise bout and locomotor learning after stroke: physiological, behavioural, and computational outcomes

Charalambous

Alcântara

French

et al. 2018

The Journal of Physiology

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Gamma aminobutyric acid (GABA) receptor agonists for acute stroke

Liu

Zhang

Wang

2018

Cochrane Database of Systematic Reviews

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BackgroundGamma aminobutyric acid (GABA) receptor agonists have been shown to have a neuroprotectant e ect in reducing infarct size and improving functional outcome in animal models of cerebrovascular disease. However, the sedative e ects of GABA receptor agonists have limited their wider application in people with acute stroke, due to the potential risk of stupor. This is an update of a Cochrane Review first published in 2013, and previously updated in 2014 and 2016. ObjectivesTo determine the e icacy and safety of GABA receptor agonists in the treatment of acute stroke.

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Aerobic exercise and consecutive task‐specific training (AExaCTT) for upper limb recovery after stroke: A randomized controlled pilot study

Valkenborghs

Vliet

Nilsson

et al. 2019

Physiotherapy Res Intl

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Objective This study examined the feasibility of a parallel‐group assessor‐blinded randomized controlled trial investigating whether task‐specific training preceded by aerobic exercise (AEX + TST) improves upper limb function more than task‐specific training (TST) alone. Methods People with upper limb motor dysfunction after stroke were allocated to TST or AEX + TST. Both groups were prescribed 60 hr of TST over 10 weeks (3 × 1‐hr sessions with a therapist per week and 3 × 1 hr of home‐based self‐practice per week). The AEX + TST group performed 30 minutes of aerobic exercise immediately prior to the 1 hr of TST with the therapist. Recruitment, adherence, retention, participant acceptability, and adverse events were recorded. Clinical measures were performed prerandomization at baseline, on completion of the intervention, and at 1‐ and 6‐month follow‐up. Results Fifty‐nine persons after stroke were screened, 42 met the eligibility criteria, and 20 (11 male; mean [SD] age: 55.4 [16.0] years; time since stroke: 71.7 [91.2] months) were recruited over 17 months. The mean Wolf Motor Function Test Functional Ability Score at baseline was 27.4 (max = 75) and the mean Action Research Arm Test score was 11.2 (max = 57). Nine were randomized to AEX + TST and 11 to TST. There were no adverse events, but there was one drop out. Retention at 1‐ and 6‐month follow‐up was 80% and 85%, respectively. Attendance was 93% (6) for the AEX + TST group, and 89% (9) for the TST group. AEX + TST was perceived as acceptable (100%) and beneficial (87.5%). Exertional fatigue (visual analogue scale) prior to TST was worse in the AEX + TST group (3.5 [0.7] out of 10) than the TST group (1.7 [1.4] out of 10). The TST group performed 31% more repetitions per session than the AEX + TST group. Conclusion A subsequent Phase III study is feasible, but modifications to eligibility criteria, outcome measures, and intervention delivery are recommended.

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A Single Bout of High-Intensity Interval Training Improves Motor Skill Retention in Individuals With Stroke

Cited by 87 publications

References 62 publications

A single exercise bout and locomotor learning after stroke: physiological, behavioural, and computational outcomes

A single exercise bout and locomotor learning after stroke: physiological, behavioural, and computational outcomes

Gamma aminobutyric acid (GABA) receptor agonists for acute stroke

Aerobic exercise and consecutive task‐specific training (AExaCTT) for upper limb recovery after stroke: A randomized controlled pilot study

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