A single-cell atlas deconstructs heterogeneity across multiple models in murine traumatic brain injury and identifies novel cell-specific targets

Jha, Ruchira M.; Rajasundaram, Dhivyaa; Sneiderman, Chaim; Schlegel, Brent T.; O’Brien, Casey; Xiong, Zujian; Janesko-Feldman, Keri; Trivedi, Ria; Vagni, Vincent; Zusman, Benjamin E.; Catapano, Joshua S.; Eberle, Adam; Desai, Shashvat M.; Jadhav, Ashutosh P.; Mihaljevic, Sandra; Miller, Margaux; Raikwar, Sudhanshu; Rani, Anupama; Rulney, Jarrod; Shahjouie, Shima; Raphael, Itay; Kumar, Aditya; Phuah, Chia-Ling; Winkler, Ethan A.; Simon, Dennis W.; Kochanek, Patrick M.; Kohanbash, Gary

doi:10.1016/j.neuron.2024.06.021

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article4

Preprint1

Relationship

Self Cite0

Independent5

Authors

Journals

Cited by 5 publications

References 108 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

A New Clue on Diffuse Brain Swelling After Pediatric TBI

Kochanek,

Simon,

Clark

2024

JAMA Netw Open

View full text Add to dashboard Cite

The importance of diffuse brain swelling in the pathophysiology of pediatric severe and moderate traumatic brain injury (TBI) has long been touted as a distinct feature compared with adults. 1 Seminal studies carried out between 1979 and 1981 by Bruce and collagues 2 reported on the importance of this phenomenon in pediatric TBI, calling it "the syndrome of malignant brain edema." That early work suggested that the etiology of diffuse brain swelling after severe and moderate pediatric TBI was largely due to hyperemia, based on groundbreaking assessments of cerebral blood flow (CBF) quantified by xenon 133 in a small sample of children. Hyperemia was purported to increase cerebral

show abstract