A Single-center Experience in Splenic Diffuse Red Pulp Lymphoma Diagnosis

Julhakyan, Hunan; Al-Radi, Lyubov; Моисеева, Т. Н.; Danishyan, Karen; Kovrigina, А М; Glebova, S.M.; Lugovskaya, S. A.; Dvirnyk, V. N.; Khvastunova, A. N.; Yakutik, Igor; Vg, Savchenko

doi:10.1016/j.clml.2016.03.011

Cited by 7 publications

(5 citation statements)

References 17 publications

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“…Some lymphoplasmocytic cells are often observed. Other series were later reported, describing the same features 40–43 with monoclonal B cells expressing CD11c (97%), less frequently CD103 (38%) and more rarely CD123 (16%) or CD25 (3%) 39,44,45 . ANXA1 expression was negative.…”

Section: Hcl‐v/sblpn Is Very Close To Splenic Diffuse Red Pulp Lympho...mentioning

confidence: 75%

Untangling hairy cell leukaemia (HCL) variant and other HCL‐like disorders: Diagnosis and treatment

Troussard,

Maitre

2023

J Cellular Molecular Medi

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The variant form of hairy cell leukaemia (HCL‐V) is a rare disease very different from hairy cell leukaemia (HCL), which is a very well‐defined entity. The 5th WHO edition (Leukemia, 36, 2022 and 1720) classification (WHO‐HAEM5) introduced splenic lymphomas/leukaemias including four different entities: (1) HCL, (2) splenic marginal zone lymphoma (SMZL) with circulating villous cells in the peripheral blood, (3) splenic lymphoma with prominent nucleolus (SLPN), which replaced HCL‐V and CD5 negative B‐prolymphocytic leukaemia (B‐PLL), and (4) splenic diffuse red pulp lymphoma (SDRPL). All these entities have to be distinguished because of a different clinical course and the need for a different treatment. The diagnosis can be challenging because of complex cases and overlap and/or grey zones between all the entities and needs integrating clinical, histologic, immunophenotypic, cytogenetic and molecular data. We review the diagnostic criteria including clinical, immunophenotypic and molecular characteristics of patients with HCL‐V and other HCL‐like disorders including HCL, SDRPL, SMZL, B‐PLL and the Japanese form of HCL. We also discuss the different criteria allowing us to separate these different entities and we will update the recent therapeutic options that have emerged, in particular the advances with chemoimmunotherapy and/or targeted therapies.

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Section: Hcl‐v/sblpn Is Very Close To Splenic Diffuse Red Pulp Lympho...mentioning

confidence: 75%

Untangling hairy cell leukaemia (HCL) variant and other HCL‐like disorders: Diagnosis and treatment

Troussard,

Maitre

2023

J Cellular Molecular Medi

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“…SDRPL series reported by Kanellis et al 30 included 4/10 (FCM) and 1/15 (IHC) CD5 positive cases, 1/8 (FCM) CD25 positive cases, while all the HCL-jv cases tested were negative for CD5 and CD25. Two cases reported by Mollejo, et al 15 were negative for CD11c and CD103 by FCM, while 6/7 cases were positive for CD11c and 1/4 cases was positive for CD103 by FCM by Kanellis, et al 30 Moreover, Julhakyan, et al 33 reported that CD11c and CD103 were positive in all cases by FCM, but CD103 was negative in all cases by IHC. It should be noted that CD11c was moderately positive by FCM and a few lymphoid cells were positive by IHC, and that CD103 was only weakly or moderately positive by FCM.…”

Section: Discussionmentioning

confidence: 95%

“…Regarding CD103, some HCL-jv cases are brightly positive, while others are negative. Julhakyan, et al 33 reported that TRAP was positive in 1/4 SDRPL case and its positivity was weak to moderate in a few cells by both cyto-/histochemistry and IHC. TRAP was weakly positive in 2/3 reported HCL-jv cases by cyto-/histochemistry and the molecule was weakly to moderately positive in most of the cells in our case by IHC.…”

Section: A Consideration On the Relationship Between Hcl-jv And Sdrplmentioning

confidence: 99%

Hairy Cell Leukemia-Japanese Variant: Report of a Patient and Literature Review

et al. 2022

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Hairy cell leukemia-Japanese variant (HCL-jv) shares some features with, but differs in other features from, HCL variant. Recently, it has been pointed out that HCL-jv and splenic diffuse red pulp small B-cell lymphoma (SDRPL) possibly constitute the same disease. We report a patient with HCL-jv, in which the neoplastic cells in the resected spleen were positive for CD11c, CD103, tartrate-resistant acid phosphatase (by immunohistochemistry), and weakly positive for cyclin D3. They were negative for CD25, CD123, annexin A1, and BRAF V600E-derived protein. Meta-analysis of HCL-jv cases in the literature showed considerable variation in the expression of HCL-related molecules. Although the clinical features and pattern of splenic involvement of HCL-jv are similar to those of SDRPL, some cytomorphological and phenotypical differences can be pointed out. To confirm whether the weak expression of cyclin D3 in our case suggests a spectrum from HCL-jv to SDRPL or one of the characteristics of HCL-jv, further studies on a large number of cases are necessary.

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“…Если в крови более 20 % лимфоцитов имеют выросты ци-топлазмы, то речь идет о ЛКМЗС с ворсинчатыми клетками [2]. Однако наличие лимфоцитов с выроста-ми цитоплазмы свойственно также волосатоклеточно-му лейкозу (ВКЛ), его вариантной форме ВКЛ-В [5,6] и мелкоклеточной лимфоме из клеток красной пульпы селезенки (ЛКПС) [7][8][9][10].…”

Section: O N C O H E M a T O L O G Y 1 ' 2017 V O L 1unclassified

“…В публикациях показано, что антиген CD25 всегда об наруживают на поверхности опухолевых клеток при ВКЛ и никогда при ВКЛ-В [3,5] или ЛКПС [7,10], а при ЛКМЗС маркер CD25 выявляется в 25 % случа-ев [12]. В данном исследовании экспрессия CD25 на опухолевых клетках при ЛКМЗС была обнаружена в 32 % (7 / 22) случаев, что хорошо согласуется с резуль-татами E. Matutes и соавт.…”

Section: больная ш 52 года с лкмзс с трансформацией в диффузную в-unclassified

Determination of morphology and immunophenotype of circulating lymphoma cells in patients with splenic marginal zone lymphoma using an anti-CD antibody microarray

Khvastunova¹,

Al-Radi²,

Fedyanina³

et al. 2017

Onkogematologiâ

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A Single-center Experience in Splenic Diffuse Red Pulp Lymphoma Diagnosis

Cited by 7 publications

References 17 publications

Untangling hairy cell leukaemia (HCL) variant and other HCL‐like disorders: Diagnosis and treatment

Untangling hairy cell leukaemia (HCL) variant and other HCL‐like disorders: Diagnosis and treatment

Hairy Cell Leukemia-Japanese Variant: Report of a Patient and Literature Review

Determination of morphology and immunophenotype of circulating lymphoma cells in patients with splenic marginal zone lymphoma using an anti-CD antibody microarray

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