A single-center, randomized, double-blind, placebo-controlled, crossover investigation of the effects of fexofenadine hydrochloride 180 mg alone and with alcohol, with hydroxyzine hydrochloride 50 mg as a positive internal control, on aspects of cognitive and psychomotor function related to driving a car

Ridout, Fran; Shamsi, Z.; Meadows, Robert; Johnson, S.; Hindmarch, Ian

doi:10.1016/s0149-2918(03)80137-6

Cited by 46 publications

(49 citation statements)

References 31 publications

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“…However, the data mirror results from previous clinical studies carried out to assess the impact of alcohol on non-sedating, newer second-generation antihistamines such as cetirizine, ebastine, fexofenadine and loratadine 9,[11][12][13]35,36 . In a double-blind crossover study, loratadine showed no effect on any psychomotor performance parameter following a single therapeutic dose and exerted no additive effect with alcohol administered to levels expected if the patient were drinking socially (0.72 g/kg lean body mass) 37 .…”

Section: Discussionsupporting

confidence: 74%

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Effects of desloratadine and alcohol coadministration on psychomotor performance

Scharf

Berkowitz

2007

Current Medical Research and Opinion

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Section: Discussionsupporting

confidence: 74%

“…Studies testing for the interactions of second-generation antihistamines with ethanol indicate that, while ethanol impairs performance, antihistamines do not potentiate the effects of the ethanol [9][10][11][12][13] .…”

Section: Introductionmentioning

confidence: 99%

Effects of desloratadine and alcohol coadministration on psychomotor performance

Scharf

Berkowitz

2007

Current Medical Research and Opinion

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“…This supraadditive effect of alcohol on CNS depressant drugs has been reported in several psychomotor and cognitive performance studies (e.g. Burns and Moskowitz 1980;Hindmarch and Subhan 1983;Aranko et al 1985;Ridout et al 2003).…”

Section: Discussionsupporting

confidence: 61%

Effects of word frequency on recall memory following lorazepam, alcohol, and lorazepam alcohol interaction in healthy volunteers

et al. 2004

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Free recall of words has been extensively used in psychopharmacology to assess the effects of CNS-active drugs on memory functions. However, there is a relative lack of information on the impact of word frequency on the subsequent recall of words following the administration of psychoactive drugs. The present double-blind, placebo-controlled, repeated-measures experiment used lorazepam and alcohol to test the effects of word frequency on immediate and delayed word recall in 24 healthy volunteers. One half of the words contained in the lists had a high frequency (HF) of occurrence and the remainder were of low frequency (LF). The results showed that LF words were more sensitive to memory impairment than HF words. However, the more accurate recall of HF words (with respect to LF words) was eliminated when a combination of lorazepam with alcohol was administered. These findings indicate that word frequency has a significant impact on memory and, as such, is a factor to be taken into account when using memory recall tasks to assess the effects of psychoactive drugs on memory.

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“…The intake of small quantities of alcohol leads to neuronal excitation and improved mood, whereas the intake of high quantities causes neuronal inhibition, which decreases visual perception and information processing, and, finally, results in an increased reaction time [1,3,7,9,12,16]. A fall is an accident with low kinetic energy, usually allowing victims with normal reaction times to protect the head with their hands and arms.…”

Section: Introductionmentioning

confidence: 99%