A Single-Center Trial to Evaluate the Efficacy and Tolerability of Four Microneedling Treatments on Fine Lines and Wrinkles of Facial and Neck Skin in Subjects With Fitzpatrick Skin Types I-IV: An Objective Assessment Using Noninvasive Devices and 0.33-mm Microbiopsies

Wamsley, Christine E; Kislevitz, Mikaela; Barillas, Jennifer; Basci, Deniz; Kandagatla, Vishal; Hitchcock, Thomas; Akgul, Yucel; Kenkel, Jeffrey M.

doi:10.1093/asj/sjab052

Cited by 13 publications

(23 citation statements)

References 47 publications

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“…Based on these promising results, the following study was performed to assess the effectiveness of the microneedling pen for treating wrinkles on the face and neck. This paper is a subjective endpoints companion to the earlier‐published objective endpoints paper, where noninvasive measurements and biopsy data of the face showed changes in skin architecture and collagen/elastin gene expression, suggesting skin rejuvenation, with new extracellular matrix production and muscle formation 16 …”

Section: Introductionmentioning

confidence: 90%

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Efficacy and tolerability of a microneedling device for treating wrinkles on the face

Alqam¹,

Wamsley

Hitchcock

et al. 2022

J of Cosmetic Dermatology

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Objectives: A microneedling pen has been cleared by the US Food and Drug Administration, indicated for improving the appearance of adult facial acne scars. The objective of this study was to assess the device's effectiveness for treating wrinkles of the face area. Materials and Methods:Healthy adults seeking to improve the appearance of face wrinkles were enrolled (N = 35), receiving four monthly microneedling procedures by a trained aesthetician who treated the face skin per manufacturer instructions. Wrinkle assessments were performed by two trained blinded raters by comparing baseline images of each subject with images obtained at 90 days post-procedure. Subsequently, the two raters were unblinded for the Clinician's Global Aesthetic Improvement Scale (CGAIS) assessment. Subjects completed the Subject's Global Aesthetic Improvement Scale (SGAIS) and a Satisfaction Questionnaire at 30 and 90 days post-treatment. Results:The study was completed by 32 subjects with a mean (SD) age of 56.3 (5.0) years. Wrinkle assessments demonstrated significant improvement in the face areas (p < 0.001). The SGAIS scores showed significant improvements after 30 and 90 days post-treatment (for each, p < 0.001). The CGAIS scores also showed significant improvements at 90 days post-treatment (p < 0.001). Most subjects reported some level of improvement in their appearance at 30 days (73.3%) and 90 days (68.8%) post-treatment. The satisfaction questionnaire showed high levels of improvement in wrinkles (93.8%), satisfaction with the treatment procedure (87.5%) and would recommend microneedling to friends and family members (80.6%) on the face and neck. Conclusion:Microneedling is a viable, minimally invasive option for treating wrinkles of the face. ClinicalTrials.gov Identifier: NCT03803059.

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Section: Introductionmentioning

confidence: 90%

“…This paper is a subjective endpoints companion to the earlier‐published objective endpoints paper, where noninvasive measurements and biopsy data of the face showed changes in skin architecture and collagen/elastin gene expression, suggesting skin rejuvenation, with new extracellular matrix production and muscle formation. 16 …”

Section: Introductionmentioning

confidence: 99%

Efficacy and tolerability of a microneedling device for treating wrinkles on the face

Alqam¹,

Wamsley

Hitchcock

et al. 2022

J of Cosmetic Dermatology

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“…Exclusion criteria included pregnancy, lactation or trying to conceive; use of a blackcurrant/redcurrant or polyphenol supplement in the past 2 months, use of chemical peels or dermabrasion in the last 6 months or use of hormone replacement therapy. To control for skin type influences on skin ageing, skin phototypes V and VI were excluded because they may experience photoageing at a deaccelerated pace 8 …”

Section: Reportmentioning

confidence: 99%

“…To control for skin type influences on skin ageing, skin phototypes V and VI were excluded because they may experience photoageing at a deaccelerated pace. 8 …”

Section: Reportmentioning

confidence: 99%

Efficacy of MitoHeal® supplementation on adult skin quality and patient satisfaction: a randomized, double-blind, placebo-controlled, pilot study

Hooper

Hausenblas

Winters

2022

Clinical and Experimental Dermatology

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Aim. Polyphenols, the most abundant natural biochemicals found in fruits, vegetables seeds, red wine, cocoa, coffee and spices, may have cosmetic and health effects. Methods. This was a 1-month randomized, placebo-controlled study, approved by the institutional review board. In total, 40 adults (mean age 44.65 years) were randomized to one of three groups: MitoHeal â 500 mg/day, MitoHeal â 1000 mg/day or placebo drink. Measurements were expert rating of professional photos of skin quality and patient self-reported skin satisfaction at Days 0 and 30. Results. The photographs and self-report assessments revealed that, compared with placebo, MitoHeal supplementation resulted in improvements in skin quality and patient satisfaction from Day 0 to Day 30, with a dose-response relationship often evidenced (P < 0.05). No adverse events were reported. Conclusion. Pilot data revealed that MitoHeal supplementation might be effective for improving skin quality and patient satisfaction. Larger sample sizes and trial durations are needed to determine the effects of MitoHeal supplementation on beauty and overall health.

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“…This paper is a subjective endpoints companion to the previously published objective endpoints paper, where noninvasive measurements and biopsy data of the face showed changes in skin architecture and collagen/elastin gene expression, suggesting skin rejuvenation, with new extracellular matrix production and muscle formation. 16 …”

mentioning

confidence: 99%

Efficacy and Tolerability of a Microneedling Device for Treating Wrinkles on the Neck

Alqam

Wamsley

Hitchcock

et al. 2022

Aesthetic Surgery Journal

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Background A microneedling pen has been cleared by the US Food and Drug Administration and is indicated for improving the appearance of facial acne scars in adults. Objectives The objective of this study was to assess the effectiveness of this microneedling pen for treating wrinkles. This paper focusses on the results on the neck, an area of recent importance with video meetings placing physical stress on the neck area leading to wrinkles. Methods Healthy adult men and women were enrolled (N=35). Subjects received four monthly microneedling procedures at depths up to 2.5 mm. Wrinkle assessments were performed by two trained blinded raters by comparing images of each subject at baseline and at 90 days post-procedure. The two raters were unblinded for the Clinician’s Global Aesthetic Improvement Scale (CGAIS) assessment. Subjects completed the Subject’s Global Aesthetic Improvement Scale (SGAIS) and a Satisfaction Questionnaire at 30 and 90 days post-treatment for the treatment areas of the face and neck. Results The study was completed by 32 subjects. Wrinkle assessments demonstrated significant improvement in the neck areas (p<.001). The SGAIS and CGAIS showed signficant improvements at 90 days post-treatment (for each, p<.001). Most subjects reported some level of improvement in their appearance at 30 days (73.3%) and 90 days (68.8%) post-treatment. The satisfaction questionnaire showed high levels of improvement in wrinkles (93.8%), satisfaction (87.5%), and would recommend microneedling to friends and family members (80.6%). Conclusions Microneedling is a viable, minimally invasive option for treating wrinkles of the neck

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A Single-Center Trial to Evaluate the Efficacy and Tolerability of Four Microneedling Treatments on Fine Lines and Wrinkles of Facial and Neck Skin in Subjects With Fitzpatrick Skin Types I-IV: An Objective Assessment Using Noninvasive Devices and 0.33-mm Microbiopsies

Cited by 13 publications

References 47 publications

Efficacy and tolerability of a microneedling device for treating wrinkles on the face

Efficacy and tolerability of a microneedling device for treating wrinkles on the face

Efficacy of MitoHeal® supplementation on adult skin quality and patient satisfaction: a randomized, double-blind, placebo-controlled, pilot study

Efficacy and Tolerability of a Microneedling Device for Treating Wrinkles on the Neck

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