A single centre’s experience of 23 cases of total rhinectomy for the treatment of squamous cell carcinoma involving the nasal vestibule

Chabrillac, Emilien; Talawdekar, Ashish; Garikipati, S.; Varley, Iain; Sionis, Sara; Beasley, Nigel; Jackson, Richard

doi:10.1007/s00405-021-06972-6

Cited by 11 publications

(15 citation statements)

References 25 publications

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“…The 5-year LRC, DSS, and OS were 81.6%, 90.1%, and 62.5%, respectively. This is largely in line with previous literature [ 6 , 11 , 16 , 19 , 21 , 24 , 29 ]. Yet, side-by-side comparison to other studies is difficult and impractical because of the variation in treatment modalities between cohorts, as well as the differences in treatment protocols between participating centers.…”

Section: Discussionsupporting

confidence: 93%

“…However, this is dependent on both patients’ as well as physicians’ awareness [ 3 ]. Surgery, with or without adjuvant radiotherapy, is the foundation of treatment for (locally) advanced SCCNV, in particular in the case of bone involvement [ 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 ]. Both surgery and external beam radiotherapy (EBRT) provide great oncological outcomes [ 4 , 8 , 9 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

“…Surgery, with or without adjuvant radiotherapy, is the foundation of treatment for (locally) advanced SCCNV, in particular in the case of bone involvement [ 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 ]. Both surgery and external beam radiotherapy (EBRT) provide great oncological outcomes [ 4 , 8 , 9 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 ]. Brachytherapy (also known as interventional radiotherapy), however, has increasingly become the treatment modality of choice for early-stage SCCNV, as it produces superior survival, aesthetic, and functional outcomes compared to other options [ 6 , 8 , 16 , 19 , 20 , 21 , 22 , 23 , 24 ]; this is mainly because surgery may lead to deformation and require additional reconstruction [ 4 , 10 , 11 , 18 , 23 , 25 ].…”

Section: Introductionmentioning

confidence: 99%

“…Both surgery and external beam radiotherapy (EBRT) provide great oncological outcomes [ 4 , 8 , 9 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 ]. Brachytherapy (also known as interventional radiotherapy), however, has increasingly become the treatment modality of choice for early-stage SCCNV, as it produces superior survival, aesthetic, and functional outcomes compared to other options [ 6 , 8 , 16 , 19 , 20 , 21 , 22 , 23 , 24 ]; this is mainly because surgery may lead to deformation and require additional reconstruction [ 4 , 10 , 11 , 18 , 23 , 25 ]. Meanwhile, systemic therapy (i.e., chemotherapy, immunotherapy, or targeted therapy) is mostly reserved for niche cases (e.g., distant metastases or inoperable disease) and is generally not considered standard treatment [ 26 ].…”

Section: Introductionmentioning

confidence: 99%

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Validation of the “Rome” Classification for Squamous Cell Carcinoma of the Nasal Vestibule

Scheurleer,

de Ridder,

Tagliaferri

et al. 2023

Cancers

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Squamous cell carcinoma of the nasal vestibule is considered a rare malignancy that differs from other sinonasal malignancies in many respects. Four staging systems currently exist for this disease, the most recent addition being the “Rome” classification. This study assesses the use of this new classification and its prognostic value regarding various outcome measures. A retrospective multicenter cohort study of patients with a primary squamous cell carcinoma of the nasal vestibule who were treated in three tertiary head and neck oncology referral centers was conducted. A total of 149 patients were included. The median follow-up duration was 27 months. Five-year locoregional control (LRC), disease-specific survival (DSS), and overall survival (OS) were 81.6%, 90.1, and 62.5% respectively. A statistically significant association was observed between the Rome classification and all survival outcomes in both univariable and multivariable analyses. Moreover, it appeared to perform better than the Union for International Cancer Control TNM classification for tumors of the nasal cavity and paranasal sinuses. The new Rome classification can be used effectively and is associated with LRC, DSS, and OS. However, it requires further validation in a larger (prospective) study population.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Validation of the “Rome” Classification for Squamous Cell Carcinoma of the Nasal Vestibule

Scheurleer,

de Ridder,

Tagliaferri

et al. 2023

Cancers

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“…Chabrillac 21 demonstrated that positive margins after TR were predictive of tumor recurrence; age was found to significantly correlate with OS at both uni-and multivariable analysis by Filtenborg. 17 Similar results were presented in our series, as positive margins were associated with worse DSS (p = 0.018), as well as age was associated with worse OS and DFS at both uni-and multivariable analysis.…”

Section: Discussionmentioning

confidence: 98%

Squamous Cell Carcinoma of the Nasal Vestibule: A Multi‐Centric Observational Cohort Study

Pirola,

Di Santo,

Turri‐Zanoni

et al. 2023

The Laryngoscope

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ObjectivesSquamous cell carcinoma of the nasal vestibule (NV‐SCC) is a rare but challenging entity, due to the complex anatomy of the region. Consensus on the best treatment strategy is still lacking, as well as a dedicated staging system. Our aim was to analyze oncological outcomes of surgically treated patients and to investigate possible prognostic factors.MethodsWe performed a retrospective multi‐centric observational study including six Academic Hospitals over a 10‐year period, including only patients who underwent upfront surgery for primary NV‐SCC. Patients were staged according to all currently available staging systems. The Kaplan–Meier method was used to compute overall, disease‐free, and disease‐specific survival. Logistic regression models were used to correlate between survival outcomes and clinical and pathological variables.ResultsSeventy‐one patients with a median follow‐up of 38 months were included in the study. Partial and total rhinectomy were the most commonly performed procedures, respectively, in 49.3% and 25.4% of cases. Neck dissection was performed on 31% of patients, and 45.1% of them underwent adjuvant radiotherapy. Three years overall, disease‐specific and disease‐free survival were, respectively, 86.5%, 90.3%, and 74.2%. None of the currently available staging systems were able to effectively stratify survival outcomes. Factors predicting lower overall survival on multivariate analysis were age (p = 0.021) and perineural invasion (p = 0.059), whereas disease‐free survival was negatively affected by age (p = 0.033) and lymphovascular invasion (p = 0.019).ConclusionCurrently available staging systems cannot stratify prognosis for patients who underwent surgery for NV‐SCC.Level of Evidence4 Laryngoscope, 2023

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Squamous cell carcinoma of the nasal vestibule in the Netherlands: A clinical and epidemiological review of 763 cases (2008–2021)

van de Velde,

Scheurleer,

Braunius

et al. 2024

Head & Neck

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BackgroundSquamous cell carcinoma of the nasal vestibule (SCCNV) is a rare disease, distinctly different in presentation, treatment, and outcome from squamous cell carcinoma (SCC) of the nasal cavity and paranasal sinuses. However, these are often not analyzed separately.MethodsThe Netherlands Cancer Registry (NCR) and pathology reports from the Dutch Nationwide Pathology Databank (PALGA) were used to identify all newly diagnosed SCCNV cases in the Netherlands between 2008 and 2021.ResultsA total of 763 patients were included. The yearly incidence rate displayed a significant downward trend with an annual percentage change (APC) of −3.9%. The 5‐year overall survival (OS) and disease‐free survival were 69.0% and 77.2%, respectively. The 5‐year relative survival was 77.9% and improved slightly over the inclusion period. OS for patients who were staged cT3 appeared to be worse than those staged cT4a, calling the applicability of the TNM‐classification into question.ConclusionSCC of the nasal vestibule is rare, with declining incidence rates. Introducing a specific topography code for SCCNV is recommended to enhance registration accuracy. The TNM classification seems poorly applicable to SCCNV, suggesting the need to explore alternative staging methods.

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A single centre’s experience of 23 cases of total rhinectomy for the treatment of squamous cell carcinoma involving the nasal vestibule

Cited by 11 publications

References 25 publications

Validation of the “Rome” Classification for Squamous Cell Carcinoma of the Nasal Vestibule

Validation of the “Rome” Classification for Squamous Cell Carcinoma of the Nasal Vestibule

Squamous Cell Carcinoma of the Nasal Vestibule: A Multi‐Centric Observational Cohort Study

Squamous cell carcinoma of the nasal vestibule in the Netherlands: A clinical and epidemiological review of 763 cases (2008–2021)

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