Abstract-In this paper, a transimpedance amplifier based on a new DC offset cancellation (DCOC) method is proposed for WCDMA/LTE applications. The proposed method applies a sample and hold mechanism to the conventional DCOC method with a DC feedback loop. It prevents the removal of information around the DC, so it avoids signal-tonoise ratio degradation. It also reduces area and power consumption. It was designed in a 0.13 mm deep n-well CMOS technology and drew a maximum current of 1.58 mA from a 1.2 V supply voltage. It showed a transimpedance gain of 80 dBΩ, an inputreferred noise current lower than 0.9 pA/√Hz, an outof-band input-referred 3rd-order intercept point more than 9.5 dBm, and an output DC offset lower than 10 mV. Its area is 0.46 mm ´ 0.48 mm.