A single discriminative sensor based on supramolecular self-assemblies of an amphiphilic cholic acid-modified fluorophore for identifying multiple proteins

Fan, Junmei; Zheng, Demin; Huang, Xinyan; Ding, Liping; Xin, Yunhong; Fang, Yu

doi:10.1016/j.snb.2018.02.132

Cited by 22 publications

(13 citation statements)

References 53 publications

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“…Considering the advancement of nanotechnology and nanoscience, nanostructured micellar probes have been considered as a promising candidate for bio-sensing owing to their structural flexibility and versatility [62]. However, only a handful of luminescent biosensor probes based on micellar systems appeared in the recent literature [16][17][18][19][20][63][64][65][66][67][68][69][70][71][72][73][74]. We will provide a very brief glimpse on these luminescent biosensors, which are used to create self-assembled nanostructure materials showing promise for use as next generation potential as "functional materials".…”

Section: Luminescent Micellar Systems For Bio Sensingmentioning

confidence: 99%

Nanostructured Luminescent Micelles: Efficient “Functional Materials” for Sensing Nitroaromatic and Nitramine Explosives

et al. 2022

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Luminescent micelles are extensively studied molecular scaffolds used in applied supramolecular chemistry. These are particularly important due to their uniquely organized supramolecular structure and chemically responsive physical and optical features. Various luminescent tags can be incorporated with these amphiphilic micelles to create efficient luminescent probes that can be utilized as “chemical noses” (sensors) for toxic and hazardous materials, bioimaging, drug delivery and transport, etc. Due to their amphiphilic nature and well-defined reorganized self-assembled geometry, these nano-constructs are desirable candidates for size and shape complementary guest binding or sensing a specific analyte. A large number of articles describing micellar fluorogenic probes are reported, which are used for cation/anion sensing, amino acid and protein sensing, drug delivery, and chemo-sensing. However, this particular review article critically summarizes the sensing application of nitroaromatic (e.g., trinitrotoluene (TNT), trinitrobenzene (TNB), trinitrophenol (TNP), dinitrobenzene (DNB), etc.) and nitramine explosives (e.g., 1,3,5-trinitro-1,3,5-triazinane, trivially named as “research department explosive” (RDX), 1,3,5,7-tetranitro-1,3,5,7-tetrazocane, commonly known as “high melting explosive” (HMX) etc.). A deeper understanding on these self-assembled luminescent “functional materials” and the physicochemical behavior in the presence of explosive analytes might be helpful to design the next generation of smart nanomaterials for forensic applications. This review article will also provide a “state-of-the-art” coverage of research involving micellar–explosive adducts demonstrating the intermolecular charge/electron transfer (CT/ET) process operating within the host–guest systems.

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Section: Luminescent Micellar Systems For Bio Sensingmentioning

confidence: 99%

Nanostructured Luminescent Micelles: Efficient “Functional Materials” for Sensing Nitroaromatic and Nitramine Explosives

et al. 2022

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“…A deoxycholic-based macrocycle sensor was shown to discriminate amino acids enantioselectively due to the chiral properties of deoxycholic acid (Wu et al, 2017). (Fan et al, 2018). Reproduced with permission, Copyright 2018 Elsevier the modification of materials using BAs.…”

Section: Bile Acid Templates For Biosensorsmentioning

confidence: 99%

“…To further benefit from properties of BAs, many investigators used them as templates for sensor design. Their self‐assembly ability was acquired by synthesis of a novel cholic acid‐modified pyrene derivative (Fan et al, 2018). The obtained fluorescent molecule is amphiphilic due to the introduction of cholic acid and allows for the fabrication of supramolecular assemblies, which provide ratiometric responses and high selectivity to bovine serum albumin and human serum albumin (Figure 8).…”

Section: Fabrication Of Biosensorsmentioning

confidence: 99%

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Application of bile acids for biomedical devices and sensors

2020

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Bile acids (BAs) are physiologically important biosurfactants (Singh, Metrani, Shivanagoudra, Jayaprakasha, & Patil, 2019), which solubilize cholesterol, lipids, proteins, fatty acids, monoglycerides and vitamins in a human body. The strong solubilization power of BAs is related to their amphiphilic chemical structure, which is fundamentally different from the structures of other surfactants. As a general feature, natural BAs molecules have a steroid nucleus with concave hydrophilic and convex hydrophobic sides, containing OH and methyl groups, respectively (Figure 1a and Table 1). The chemical structures of BAs contain a short hydrocarbon chain with COOH or SO 3 H end groups. As a result, dissociated BAs molecules exhibit anionic properties in solutions. Properties of BAs are influenced by the number of OH groups bonded to a steroid core and nature of anionic groups. Modifying the hydroxyl or carboxyl groups of BAs creates a diverse set of BA-based compounds, maintaining some original properties and introducing novel properties as well. The unique distribution of hydrophilic and hydrophobic domains allows these molecules to self-organize into supramolecular assemblies in water. BAs salts form mixed micelles (Figure 1b) with various water-insoluble molecules and facilitate their dissolution. Moreover, BAs allow dispersion of hydrophobic materials, such as carbon nanotubes (Ata, Poon, Syed, Milne, & Zhitomirsky, 2018). The bifacial amphipathic BAs molecules act as compatibilizing agents between the water-insoluble

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“…In addition, our group also synthesized an amphiphilic cholic acid-modified pyrene derivative, and found that it could form spherical aggregates and emit multiple fluorescence emission bands in aqueous solution (Fan et al, 2018 ). This fluorescent assembly showed ratiometric selective response to BSA or HSA among non-metalloproteins due to the disassembly of probe aggregates.…”

Section: Multi-wavelength-based Single Sensing System For Protein Recmentioning

confidence: 99%

Array-Based Discriminative Optical Biosensors for Identifying Multiple Proteins in Aqueous Solution and Biofluids

Fan

Han

et al. 2020

Front. Chem.

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Identification of proteins is an important issue both in medical research and in clinical practice as a large number of proteins are closely related to various diseases. Optical sensor arrays with recognition ability have been flourished to apply for distinguishing multiple chemically or structurally similar analytes and analyzing unknown or mixed samples. This review gives an overview of the recent development of array-based discriminative optical biosensors for recognizing proteins and their applications in real samples. Based on the number of sensor elements and the complexity of constructing array-based discriminative systems, these biosensors can be divided into three categories, which include multi-element-based sensor arrays, environment-sensitive sensor arrays and multi-wavelength-based single sensing systems. For each strategy, the construction of sensing platform and detection mechanism are particularly introduced. Meanwhile, the differences and connections between different strategies were discussed. An understanding of these aspects may help to facilitate the development of novel discriminative biosensors and expand their application prospects.

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A single discriminative sensor based on supramolecular self-assemblies of an amphiphilic cholic acid-modified fluorophore for identifying multiple proteins

Cited by 22 publications

References 53 publications

Nanostructured Luminescent Micelles: Efficient “Functional Materials” for Sensing Nitroaromatic and Nitramine Explosives

Nanostructured Luminescent Micelles: Efficient “Functional Materials” for Sensing Nitroaromatic and Nitramine Explosives

Application of bile acids for biomedical devices and sensors

Array-Based Discriminative Optical Biosensors for Identifying Multiple Proteins in Aqueous Solution and Biofluids

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