A single institution experience of the incidence of extracranial metastasis in glioma

Amitendu, Sekhar; Mak, Siu Kei David; Ling, Ji Min; Ng, Wai Hoe

doi:10.1016/j.jocn.2011.08.040

Cited by 36 publications

(27 citation statements)

References 19 publications

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“…Since this initial report of extra-cranial metastasis, the underlying mechanism of this phenomenon has yet to be completely elucidated and only few cases have been reported. However, the incidence of extra-cranial metastasis as reported in an earlier autopsy series was much higher which suggests that the true incidence of these distant metastases may be significantly higher than what has been clinically detected [2,7,8].…”

Section: Discussionmentioning

confidence: 85%

“…Glioblastoma (GBM) is one of the most highly aggressive neoplasms that originates from central nervous system (CNS) glial elements [1]. This tumor is also the most common glial neoplasm in the CNS, and its incidence increase in the elderly population [1,2]. GBM is classified according to the World Health Organization (WHO) system as grade IV tumors [3].…”

Section: Introductionmentioning

confidence: 99%

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Glioblastoma Metastasis to Parotid Gland and Neck Lymph Nodes: Fine-Needle Aspiration Cytology with Histopathologic Correlation

Romero‐Rojas

Díaz-Pérez

Amaro

et al. 2013

Head and Neck Pathol

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Glioblastoma (GBM) is one of the most highly aggressive neoplasms of the central nervous system. Extra-cranial metastases in GBM are rare. Here we present the case of a 26-year-old man with extra-cranial metastasis of a frontal lobe GBM to the parotid gland, cervical lymph nodes, and bones, with initial diagnosis made by fine needle aspiration cytology (FNAC) of the parotid gland. FNAC is a reliable technique in the study of primary and secondary parotid gland neoplasms, allowing a presumptive diagnosis in difficult cases. We correlate the cytologic, histopathologic, and immunohistochemical findings in this case and discuss previous literature reports.

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Section: Discussionmentioning

confidence: 85%

Section: Introductionmentioning

confidence: 99%

Glioblastoma Metastasis to Parotid Gland and Neck Lymph Nodes: Fine-Needle Aspiration Cytology with Histopathologic Correlation

Romero‐Rojas

Díaz-Pérez

Amaro

et al. 2013

Head and Neck Pathol

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“…Circulating tumor cells in peripheral blood are increasingly found across cancers, including in 21% of GBM patients [5]. In comparison, another study noted an only 2.7% incidence of extracranial invasion among 148 GBM patients over 5 years [4]. Thus, it is unclear why extracranial GBM is not observed at an even higher rate than currently reported.…”

Section: Discussionmentioning

confidence: 95%

“…In our patient, the tumor appears to have spread through a combination of postsurgical seeding through a prior burr hole and direct extension through the bone. Reports of tumor invasion to the skull and overlying scalp tissues are rare [3,4].…”

Section: Discussionmentioning

confidence: 99%

Extracranial growth of glioblastoma multiforme

Forsyth

Abedalthagafi

et al. 2015

Journal of Clinical Neuroscience

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“…[22124] The exact number maybe even higher as GBM is a rapidly progressive disease in which many patients probably die before spinal metastasis become symptomatic. Technological advances have slightly improved the life expectancy of patients with GBM and increased use of MRI may lead to a higher incidence being reported in the future.…”

Section: Discussionmentioning

confidence: 99%

Is surgical spinal decompression for supratentorial GBM symptomatic drop down metastasis warranted? A case report and review of literature

2014

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Background:Symptomatic spinal metastasis from an intracranial primary glioblastoma multiforme (GBM) is very rare. Our literature search identified a total of 42 such patients of which 11 were treated with surgical decompression for spinal metastasis with only one such report from the pediatric age group. Previous studies have reported variable outcomes after surgical management.Case Description:We report the case of a 16-year-old boy who underwent surgical spinal decompression for spinal metastasis after intracranial GBM. The patient regained motor and autonomic function following surgery and reported improvement in pain. We also present findings from a literature review using the PubMed database from 1985 to June 2013 on this subject and compare radiation therapy with surgical decompression as palliative modalities in such patients.Conclusion:There are no evidence-based guidelines available on the subject and no treatment regimen has yet demonstrated survival benefit in these patients. Surgical decompression may be a better option for patients with focal resectable lesions and who are medically stable to tolerate the procedure.

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A single institution experience of the incidence of extracranial metastasis in glioma

Cited by 36 publications

References 19 publications

Glioblastoma Metastasis to Parotid Gland and Neck Lymph Nodes: Fine-Needle Aspiration Cytology with Histopathologic Correlation

Glioblastoma Metastasis to Parotid Gland and Neck Lymph Nodes: Fine-Needle Aspiration Cytology with Histopathologic Correlation

Extracranial growth of glioblastoma multiforme

Is surgical spinal decompression for supratentorial GBM symptomatic drop down metastasis warranted? A case report and review of literature

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