A Single-Institution Radical Surgery Results in Stage IB2/IIA2 (Bulky) Cervical Cancer

Khatib, Ghanim; Güleç, Ümran Küçükgöz; Güzel, Ahmet Barış; Uygur, Berk; Şeydaoğlu, Gülşah; Gümürdülü, Derya; Vardar, Mehmet Ali

doi:10.1097/igc.0000000000000786

Cited by 3 publications

(3 citation statements)

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“…RS is aimed at removing the primary cervical lesion and surrounding tissue that may be involved, thereby reducing the risk of local recurrence and distant metastasis (20). In this study, 14.3% of patients relapsed, similar to the results of previous studies involving bulky early-stage CC treated with RS (10%-24.7%) (21)(22)(23). Keys et al (14) reported recurrence rates of 21% and 37% in patients with stage IB2 CC received with CCRT and RT alone, respectively, which were higher than the recurrence rates in this study.…”

Section: Discussionsupporting

confidence: 89%

Radical surgery for stage IB2/IIA2 cervical cancer: A large retrospective study

et al. 2022

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BackgroundWe aimed to evaluate survival, complications, and prognostic factors in patients with IB2/IIA2 (FIGO 2009, bulky early-stage) cervical cancer (CC) who were primarily treated with radical surgery (RS).MethodsFrom January 2011 to January 2018, patients with stage IB2/IIA2 CC who underwent RS ± adjuvant therapy were enrolled and retrospectively evaluated. Survival was estimated using the Kaplan–Meier method. Significance was determined using the log-rank test. Multivariate regression analyses were performed to determine prognostic factors.ResultsOf the 975 enrolled patients, 877 (89.9%) received adjuvant therapy. The median follow-up was 48 months, the 5-year overall survival (OS) was 85.9%, and the 5-year progression-free survival (PFS) rate was 80.8%. Multivariate analysis showed that histological type, pelvic lymph nodes, and para-aortic lymph nodes were independent prognostic factors for PFS and OS. Tumor diameter was also an independent prognostic factor with OS. Recurrent disease developed in 14.3% (140) of patients., including local, distant, and both recurrences in 55 (5.6%), 71 (7.3%), and 14 (1.4%) patients, respectively. Grade 3–4 short-term complications occurred in 196 (20.1%) patients, and long-term complications occurred in 86 (8.8%) patients. Short-term hematological complications occurred in 99 cases (10.2%). No significant differences in non-hematological complications were detected between the RS and RS + adjuvant therapy groups.ConclusionsRS followed by adjuvant therapy is a feasible and effective treatment for IB2/IIA2 CC, with a high 5-year survival rate and an acceptable incidence of complications. Positive pelvic lymph nodes and para-aortic abdominal lymph nodes significantly impact PFS and OS. Evaluation of lymph node status before surgery is important. RS is recommended for patients with negative lymph node metastasis.

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Section: Discussionsupporting

confidence: 89%

Radical surgery for stage IB2/IIA2 cervical cancer: A large retrospective study

et al. 2022

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“…For stage IB2/IIA2 cervical cancer, concurrent chemoradiotherapy and radical hysterectomy + individualized postoperative adjuvant therapy were acceptable treatments, while the FIGO and NCCN guidelines indicated that because of the large diameter of IB2/IIA2 cervical cancer, the possibility of supplementing high and intermediate risk factors for radiotherapy after surgery was high, so platinum‐based concurrent chemoradiotherapy was a better choice for patients with IB2/IIA2 cervical cancer 1, 3 . In Europe, South Korea, China, and Japan, there have been reports of surgical treatment of patients with stage IB2/IIA2 cervical cancer, 9, 19–21 but they paid more attention to laparoscopic conditions such as bleeding volume, operation time, intraoperative postoperative complications, etc. There was no multicenter large‐scale report on tumor prognosis without preoperative adjuvant therapy.…”

Section: Discussionmentioning

confidence: 99%

Comparison of survival outcomes between laparoscopic surgery and abdominal surgery for radical hysterectomy as primary treatment in patients with stage IB2/IIA2 cervical cancer

Chen

Guo

Liu

et al. 2021

J of Obstet and Gynaecol

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Objective To investigate the long‐term oncological outcomes of laparoscopic radical hysterectomy (LRH) and abdominal radical hysterectomy (ARH) for the treatment of stage IB2/IIA2 cervical cancer without preoperative adjuvant therapy. Methods We conducted a multicenter, retrospective, case‐matching study. The differences in overall survival (OS) and disease‐free survival (DFS) between the LRH and ARH were compared under the conditions of real‐world study and case–control matching (1:1 matching). Results There was no significant difference in the outcomes of LRH (n = 580) and ARH (n = 1653) in 5‐year OS and DFS (OS: 80.6% vs. 86.1%, p = 0.421; DFS: 78.6% vs. 80.7%, p = 0.376). After 1:1 matching, there was no difference in 5‐year OS and DFS between LRH (n = 554) and ARH (n = 554) (OS: 80.4% vs. 84.5%, p = 0.993; DFS: 79.0% vs. 78.8%, p = 0.695). Before and after matching, the surgical approach was not an independent risk factor for 5‐year OS and DFS, and postoperative adjuvant therapy affected patient prognosis. Further subgroup analysis suggested that there was no difference in LRH (n = 313) and ARH (n = 1092) in 5‐year OS or DFS in patients who underwent standard postoperative adjuvant therapy (OS: 83.0% vs. 87.7%, p = 0.992; DFS: 79.0% vs. 82.5%, p = 0.323). After 1:1 pairing, the 5‐year OS and DFS in LRH (n = 295) and ARH (n = 295) showed no difference. Before and after matching, the surgical approach was not an independent risk factor affecting the 5‐year OS and DFS. Conclusions There was no difference in the oncological outcomes between laparoscopic and abdominal surgery in patients with stage IB2/IIA2 cervical cancer without preoperative adjuvant therapy. Clinical Trials The ethical approval number is NFEC‐2017‐135, and the clinical research registration number is CHiCTR1800017778 (International Clinical Trials Registry Platform Search Port, http://apps.who.int/trialsearch/).

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“…Definitive CCRT may lead to adverse effects such as ovarian function damage, cystitis, proctitis or hematological toxicity; however, surgery continues to be the major treatment for IB2 and IIA2 disease in some countries or regions suffered from limitation of the radiation equipment and technology. The tumors > 4 cm increase the difficulty of the operation, and thus, the patients with IB2 and IIA2 disease need a comprehensive therapeutic strategy [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

MRI outcome evaluation in patients with IB2 and IIA2 squamous cervical cancer stages: preliminary results

et al. 2022

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Objectives To evaluate the therapeutic effect of neoadjuvant therapy (NAT) followed by radical hysterectomy and concurrent chemoradiotherapy (CCRT) in stage IB2 and IIA2 squamous cervical cancer (SCC) and investigate the value of apparent diffusion coefficient (ADC) in outcome evaluation of different treatment strategies in the patients. Methods A total of 149 patients with IB2 and IIA2 SCC who underwent pretreatment MRI and DWI scan were included. Patients were treated with NAT + RH or CCRT. Clinical indices and pathological factors were recorded. The imaging indices were measured including tumor size and tumor ADC values. Intraclass correlation coefficient was employed to evaluate the consistency of the indices measured by two observers. ROC curves were used to evaluate the cutoff values of clinical and imaging indices. Kaplan–Meier and Cox proportional hazard model were used to analyze the independent factors of disease-free survival (DFS). Results The median follow-up period was 42.3 months. SCC-Ag, ADCmax and ADCmin were independent factors for DFS in the entire cohort. SCC-Ag, ADCmin and vascular invasion were independent factors for DFS in NAT + RH group. ADCmax and ADCmin were independent factors for DFS in CCRT group. ADCmin was the strongest independent factor for DFS in NAT + RH group, while ADCmax was that in CCRT group. Conclusion The NAT + RH patients had similar DFS to that of CCRT in IB2 and IIA2 SCC, which could be a potential feasible alternative treatment. ADCmin and ADCmax were more valuable in evaluating the outcome of patients who underwent NAT + RH or CCRT, respectively.

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A Single-Institution Radical Surgery Results in Stage IB2/IIA2 (Bulky) Cervical Cancer

Abstract: Although adjuvant therapies are often resorted to, primary radical surgery is also a reasonable treatment option for stage IB2/IIA2 cervical cancer, especially in young premenopausal patients when preserving ovarian functions is desired.

Cited by 3 publications

References 16 publications

Radical surgery for stage IB2/IIA2 cervical cancer: A large retrospective study

Radical surgery for stage IB2/IIA2 cervical cancer: A large retrospective study

Comparison of survival outcomes between laparoscopic surgery and abdominal surgery for radical hysterectomy as primary treatment in patients with stage IB2/IIA2 cervical cancer

MRI outcome evaluation in patients with IB2 and IIA2 squamous cervical cancer stages: preliminary results

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