A Single Liver Metastasis From Adenoid Cystic Carcinoma of the Parotid Gland: Case Report

Zemni, Inès; Tounsi, Noureddine; Bouraoui, I; Slimene, M.F. Ben; Sahraoui, Ghada; Ayadi, Mohamed; Chargui, Riadh; Rahal, Khaled

doi:10.1177/2324709619879631

Cited by 8 publications

(12 citation statements)

References 14 publications

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“…2,5-7 ACC liver metastases initially have slow growth and become symptomatic when the hepatic parenchyma is compromised. In a few studies, 2,6,7 it has been reported that ACC nodules were palpable or caused hepatomegaly. In the present case, the patient was asymptomatic and the diagnosis was made during the follow-up.…”

Section: Discussionmentioning

confidence: 99%

“…According to the literature, surgery is the most curative treatment for distant metastasis of ACC. [5][6][7][8][9][10] Zemni et al 7 described treatment with chemoembolization for a large ACC liver metastasis but when this approach failed they moved to surgical treatment. 7 In another report, Balducci et al 8 performed a two-stage hepatectomy for four large ACC metastases of the right liver with a previous right portal vein embolization.…”

Section: Discussionmentioning

confidence: 99%

“…[5][6][7][8][9][10] Zemni et al 7 described treatment with chemoembolization for a large ACC liver metastasis but when this approach failed they moved to surgical treatment. 7 In another report, Balducci et al 8 performed a two-stage hepatectomy for four large ACC metastases of the right liver with a previous right portal vein embolization. The literature shows that surgery is a potentially curative treatment.…”

Section: Discussionmentioning

confidence: 99%

“…3 ACCs are slow-growing but distant metastases are common. 2 Metastasis to the liver, however, is unusual, [2][3][4][5][6][7] and renal metastasis is even more unusual; we found only two case reports in the literature. 9,10 Consensus concerning optimal management is lacking.…”

Section: Introductionmentioning

confidence: 99%

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Surgical treatment of liver and kidney metastasis from an adenoid cystic carcinoma of the submandibular gland: case report

Ferrari

Franceschi

Percivale

et al. 2021

Tumori

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Introduction: Adenoid cystic carcinomas (ACCs) account for 10% of all malignant salivary tumours. They are slow-growing but locally aggressive. Reports of liver and renal metastases are rare. Case description: A 58-year-old woman who had undergone resection of a left submandibular ACC in 1995 was referred to our centre for follow-up in 2018. A computed tomography scan revealed two lesions: one on segment six of the liver and the other on a kidney. A hepatic wedge resection and right nephrectomy were performed. The postoperative course was uneventful. At 2-year follow-up, the patient was alive and well with no evidence of disease. Conclusion: Management of ACC is a therapeutic challenge because of its tendency for distant metastases. The literature recommends regular follow-up imaging and radical surgical treatment but specific guidelines for the approach to recurrence are lacking.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Surgical treatment of liver and kidney metastasis from an adenoid cystic carcinoma of the submandibular gland: case report

Ferrari

Franceschi

Percivale

et al. 2021

Tumori

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“…Ten patients were found to have lung metastases before liver metastases. The other 13 case reports in PubMed were reviewed in Table 2 (5,8,(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21).…”

Section: Clinical Characteristics Of Liver Metastasesmentioning

confidence: 99%

Possible local treatment for liver metastases of adenoid cystic carcinoma (ACC): single-centre experience and literature review

Zheng¹,

He²,

Wu³

et al. 2020

Transl Cancer Res TCR

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Background: Adenoid cystic carcinoma (ACC) is a relatively indolent cancer, for which the major cause of death is distant metastases. The median survival time of patients with distant metastases of ACC is approximately 20 months. Although the liver is not the most common site of secondary ACC, effective treatment of liver metastases could improve patient survival. This study explored the clinical features and treatment of liver metastases of ACC in one centre and performed a literature review. Methods: This is a retrospective cohort study. The records of 25 ACC patients with liver metastases in our hospital from January 2000 to September 2018 and 13 case reports (from 2000 to 2018) from PubMed published in English were reviewed together. Survival curves were estimated by the Kaplan-Meier method. Multivariate cox regression analysis was used to identify risk factors for overall survival (OS). Results: Patients with liver metastases of ACC had a poor prognosis. The median survival time of patients with ACC liver metastases was 14 months (4-26 months), and the 1-, 2-, and 3-year survival rates were 55.8%, 28.5%, and 15.2%, respectively. Isolated liver metastases were more likely to benefit from local treatment, such as surgery and radiofrequency ablation (RFA), than multifocal metastases. The prognosis was worse for patients who received systemic treatment for multifocal liver metastases than for those who received other treatment. Synchronous liver metastases were the predictive factor for OS both in univariate and multivariate analysis. Conclusions: Local treatment, such as surgical resection or RFA, may prolong the survival time of ACC patients with liver metastases. The definition of resectability for liver metastases needs further investigation.

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Identification of hepatic metastasis from an unrevealed adenoid cystic carcinoma by PET/CT: A case report

Liang,

Ding,

Sui

et al. 2024

Medicine

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Rationale: Adenoid cystic carcinoma is a rare malignant tumor of the salivary glands, with few reports of metastasis to the liver in the literature. We present a case where an isolated hepatic lesion of adenoid cystic carcinoma was identified using 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT). Patient concerns: A 76-year-old male experienced abdominal pain and underwent an enhanced CT scan and magnetic resonance imaging, which revealed a liver mass. Subsequent 18F-FDG PET/CT identified hypermetabolic lesions in both the left and right lobes of the liver, suggesting malignancy, with no other abnormalities detected. Diagnoses: A liver biopsy confirmed the diagnosis of adenoid cystic carcinoma. Interventions: No intervention. Outcomes: Following confirmation of the diagnosis, the patient chose to discontinue treatment and was discharged. Lessons: Hepatic metastasis from adenoid cystic carcinoma may be detected before the identification of the primary lesion. 18F-FDG PET/CT plays a critical role in differentiating benign from malignant liver tumors, selecting potential biopsy sites, and assessing the extent of metastatic disease.

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A Single Liver Metastasis From Adenoid Cystic Carcinoma of the Parotid Gland: Case Report

Cited by 8 publications

References 14 publications

Surgical treatment of liver and kidney metastasis from an adenoid cystic carcinoma of the submandibular gland: case report

Surgical treatment of liver and kidney metastasis from an adenoid cystic carcinoma of the submandibular gland: case report

Possible local treatment for liver metastases of adenoid cystic carcinoma (ACC): single-centre experience and literature review

Identification of hepatic metastasis from an unrevealed adenoid cystic carcinoma by PET/CT: A case report

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