A single major chromosomal region controls natural killer cell-like activity in rainbow trout

Zimmerman, Anastasia M.; Evenhuis, Jason P.; Thorgaard, Gary H.; Ristow, Sandra S.

doi:10.1007/s00251-004-0645-6

Cited by 62 publications

(7 citation statements)

References 56 publications

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“…Another bony fish, Oreochromis niloticus, possesses a KLR region, containing 26 genes, though more compact than its human counterpart [105]. Other teleosts have NKC genes, including Paralabidochromis chilotes [106] and rainbow trout [107], demonstrating that some of these genes arose in an ancestor common to both humans and bony fish earlier in the gnathostome lineage.…”

Section: Nk Receptor Gene Complexes In Other Speciesmentioning

confidence: 99%

Comparative Genomics of Natural Killer Cell Receptor Gene Clusters

Kelley¹,

Walter²,

Trowsdale³

2005

PLoS Genet

263

189

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Many receptors on natural killer (NK) cells recognize major histocompatibility complex class I molecules in order to monitor unhealthy tissues, such as cells infected with viruses, and some tumors. Genes encoding families of NK receptors and related sequences are organized into two main clusters in humans: the natural killer complex on Chromosome 12p13.1, which encodes C-type lectin molecules, and the leukocyte receptor complex on Chromosome 19q13.4, which encodes immunoglobulin superfamily molecules. The composition of these gene clusters differs markedly between closely related species, providing evidence for rapid, lineage-specific expansions or contractions of sets of loci. The choice of NK receptor genes is polarized in the two species most studied, mouse and human. In mouse, the C-type lectin-related Ly49 gene family predominates. Conversely, the single Ly49 sequence is a pseudogene in humans, and the immunoglobulin superfamily KIR gene family is extensive. These different gene sets encode proteins that are comparable in function and genetic diversity, even though they have undergone species-specific expansions. Understanding the biological significance of this curious situation may be aided by studying which NK receptor genes are used in other vertebrates, especially in relation to species-specific differences in genes for major histocompatibility complex class I molecules.

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Section: Nk Receptor Gene Complexes In Other Speciesmentioning

confidence: 99%

Comparative Genomics of Natural Killer Cell Receptor Gene Clusters

Kelley¹,

Walter²,

Trowsdale³

2005

PLoS Genet

263

189

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“…The identification of QTL (Quantitative Trait Loci) paves the way for a precise investigation of the molecular genetic basis of traits. While many QTL studies have already been implemented for a range of traits, including growth [22], disease resistance [23-26], temperature tolerance [27], cortisol responsiveness [28] and early maturation [29], very little has been done regarding osmoregulation capacities in rainbow trout. Nichols et al .…”

Section: Introductionmentioning

confidence: 99%

Detection of QTL with effects on osmoregulation capacities in the rainbow trout (Oncorhynchus mykiss)

Bras¹,

Dechamp

Krieg

et al. 2011

BMC Genet

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BackgroundThere is increasing evidence that the ability to adapt to seawater in teleost fish is modulated by genetic factors. Most studies have involved the comparison of species or strains and little is known about the genetic architecture of the trait. To address this question, we searched for QTL affecting osmoregulation capacities after transfer to saline water in a nonmigratory captive-bred population of rainbow trout.ResultsA QTL design (5 full-sib families, about 200 F2 progeny each) was produced from a cross between F0 grand-parents previously selected during two generations for a high or a low cortisol response after a standardized confinement stress. When fish were about 18 months old (near 204 g body weight), individual progeny were submitted to two successive hyper-osmotic challenges (30 ppt salinity) 14 days apart. Plasma chloride and sodium concentrations were recorded 24 h after each transfer. After the second challenge, fish were sacrificed and a gill index (weight of total gill arches corrected for body weight) was recorded. The genome scan was performed with 196 microsatellites and 85 SNP markers. Unitrait and multiple-trait QTL analyses were carried out on the whole dataset (5 families) through interval mapping methods with the QTLMap software. For post-challenge plasma ion concentrations, significant QTL (P < 0.05) were found on six different linkage groups and highly suggestive ones (P < 0.10) on two additional linkage groups. Most QTL affected concentrations of both chloride and sodium during both challenges, but some were specific to either chloride (2 QTL) or sodium (1 QTL) concentrations. Six QTL (4 significant, 2 suggestive) affecting gill index were discovered. Two were specific to the trait, while the others were also identified as QTL for post-challenge ion concentrations. Altogether, allelic effects were consistent for QTL affecting chloride and sodium concentrations but inconsistent for QTL affecting ion concentrations and gill morphology. There was no systematic lineage effect (grand-parental origin of QTL alleles) on the recorded traits.ConclusionsFor the first time, genomic loci associated with effects on major physiological components of osmotic adaptation to seawater in a nonmigratory fish were revealed. The results pave the way for further deciphering of the complex regulatory mechanisms underlying seawater adaptation and genes involved in osmoregulatory physiology in rainbow trout and other euryhaline fishes.

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“…Such carefully controlled environmental and genetic conditions strongly suggest that the trade-off between growth rate and sprint swimming ability has a genetic basis; however, it is important to keep in mind that only a limited amount of the available genetic variation within a source stock is contained within a clone. A number of other traits, such as development rate (Robison et al 2001), immune response (Zimmerman et al 2004), disease resistance (Nichols et al 2003), and stress response (Drew et al 2007) have already been shown to have a genetic basis in clonal line crosses.…”

Section: Discussionmentioning

confidence: 98%

Reduced swimming performance and increased growth in domesticated rainbow trout, Oncorhynchus mykiss

Reinbold

Thorgaard

Carter

2009

Can. J. Fish. Aquat. Sci.

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Domesticated populations of rainbow trout (Oncorhynchus mykiss) probably have been selected for high growth rates and large body size, which may have resulted in reduced sprint swimming performance. We hypothesized that more domesticated populations of rainbow trout would have higher growth rates and larger body size, but slower swim speed, relative to semiwild populations. We tested this hypothesis by measuring body mass, body length, and sprint swim speed multiple times over 92 days in progeny from crosses between males from three clonal lines and an outbred female. We found significantly higher body masses and significantly slower swim speeds in the highly domesticated Arlee and Hot Creek progeny groups compared with the semiwild Swanson hybrid progeny group, supporting our hypothesis. Growth rates also differed significantly among groups, but at the ages measured, the Swanson hybrid progeny had an intermediate growth rate. However, given the differences in body mass, either growth rates were higher in the more domesticated progeny groups at young unmeasured ages and (or) they hatched at a significantly larger body mass than the semiwild Swanson hybrid.Résumé : Les populations domestiquées de truites arc-en-ciel (Oncorhynchus mykiss) ont probablement été sélectionnées pour leur fort taux de croissance et leur importante taille corporelle, ce qui peut avoir conduit à une performance réduite de la nage de pointe. Nous posons l'hypothèse selon laquelle les populations plus domestiquées de truites arc-en-ciel devraient avoir un taux de croissance plus élevé et une taille corporelle plus forte, mais une vitesse de nage plus lente, par comparaison aux populations semi-sauvages. Nous avons testé cette hypothèse en mesurant la masse corporelle, la longueur du corps et la vitesse de nage de pointe à de nombreuses reprises sur une période de 92 jours chez des rejetons de croisements entre des mâles de trois lignées clonales et une femelle exogame. La masse corporelle est significativement plus forte et la vitesse de nage significativement plus lente chez les groupes de rejetons des lignées fortement domestiquées Arlee et Hot Creek, par rapport au groupe de rejetons hybrides de la lignée semi-sauvage Swanson, ce qui confirme notre hypothèse. Les taux de croissance diffèrent aussi parmi ces groupes, mais aux âges où nous avons fait les mesures, les rejetons hybrides Swanson ont un taux de croissance intermédiaire. Cependant, compte tenu des différences de masse corporelle, il se peut que les taux de croissance aient été plus élevés dans les groupes de rejetons plus domestiqués aux âges antérieurs à nos mesures ou alors (et) que ces rejetons aient éclos avec une masse corporelle significativement plus grande que les hybrides semi-sauvages Swanson.[Traduit par la Rédaction]

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A single major chromosomal region controls natural killer cell-like activity in rainbow trout

Cited by 62 publications

References 56 publications

Comparative Genomics of Natural Killer Cell Receptor Gene Clusters

Comparative Genomics of Natural Killer Cell Receptor Gene Clusters

Detection of QTL with effects on osmoregulation capacities in the rainbow trout (Oncorhynchus mykiss)

Reduced swimming performance and increased growth in domesticated rainbow trout, Oncorhynchus mykiss

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