1998
DOI: 10.1016/s0248-8663(98)80399-8
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A single midnight serum cortisol measurement distinguishes Cushing's syndrome from pseudo-Cushing states

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Cited by 47 publications
(82 citation statements)
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“…Evaluation of cortisol level is important in the screening of Cushing's syndrome [16,17]. new diagnostic criteria for Cushing's disease revised in 2007 found high cortisol levels (> 5 µg/dL) during night time sleeping to be indicative of ACTH-dependent Cushing's syndrome in Japan.…”
Section: Discussionmentioning
confidence: 99%
“…Evaluation of cortisol level is important in the screening of Cushing's syndrome [16,17]. new diagnostic criteria for Cushing's disease revised in 2007 found high cortisol levels (> 5 µg/dL) during night time sleeping to be indicative of ACTH-dependent Cushing's syndrome in Japan.…”
Section: Discussionmentioning
confidence: 99%
“…Since lack of circadian rhythm of serum secretion is a hallmark of CS [8,12], midnight serum cortisol levels greater than 1.8 µg/dl have been reported to be indicative of CS [6]. Measurement of late-night to midnight serum cortisol, however, requires hospitalization, trained medical staff, and painful venipunctures.…”
Section: Discussionmentioning
confidence: 99%
“…Since the loss of a diurnal rhythm is the hallmark of CS, a measurement of midnight or late-night serum cortisol has been considered as a reliable way to distinguish patients with CS from healthy people [5][6][7]. Measurement of midnight or late-night serum cortisol, however, requires hospitalization, trained medical staff, and painful venipunctures.…”
mentioning
confidence: 99%
“…The most commonly used cutoff value in the literature originates from a 1998 study indicating that a cortisol value higher than 7.5 µg/dL is suggestive of Cushing's syndrome (patient at rest, but awake) with 96% sensitivity and 100% specificity (78).…”
Section: Late-night Serum Cortisolmentioning
confidence: 99%