A Single-Nucleotide Polymorphism (−670) of the Maternal Fas Gene Is Associated With Intrauterine Growth Restriction

Robinson, Royland; Hsu, Chaur‐Dong; Chesebro, Allyson L.; Nguyen, John; Ali, Noorjahan; Maramreddy, Hima; Parton, Lance

doi:10.1097/01.aoa.0000393167.08651.15

Cited by 4 publications

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“…Indeed, Sziller et al reported that the Fas‐670G allele was associated with an increased risk of IUGR in American women with pre‐eclampsia who delivered before 37 weeks of pregnancy ( n = 39). Robinson et al noted a similar association in American women without pre‐eclampsia in a small cohort ( n = 50). Interestingly, this group found that this association was present only in white mothers but not in black.…”

Section: Discussionmentioning

confidence: 99%

FAS A‐670G and Fas ligand IVS2nt A 124G polymorphisms are significantly increased in women with pre‐eclampsia and may contribute to HELLP syndrome: a case‐controlled study

Raguema

Zitouni

Gannoun

et al. 2018

BJOG

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Section: Discussionmentioning

confidence: 99%

FAS A‐670G and Fas ligand IVS2nt A 124G polymorphisms are significantly increased in women with pre‐eclampsia and may contribute to HELLP syndrome: a case‐controlled study

Raguema

Zitouni

Gannoun

et al. 2018

BJOG

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“…Recent studies have suggested that FAS and FASL gene polymorphisms in addition to other factors play important roles in pathogenesis of PE. To date, there are a few published reports of FAS gene polymorphisms in association with PE …”

Section: Discussionmentioning

confidence: 99%

“…determined the relation of the A‐670G polymorphism and IUGR in 27 pregnant women with IUGR in the absence of PE and 50 healthy pregnant women. They demonstrated an association between the maternal A‐670G polymorphism and the development of IUGR in the USA, too …”

Section: Discussionmentioning

confidence: 99%

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Association of functional polymorphisms in FAS and FASLigand genes promoter with pre‐eclampsia

Salimi

Moudi

Farajian-Mashhadi

et al. 2014

J of Obstet and Gynaecol

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Aim: Pre-eclampsia (PE) is a complex disorder of pregnancy with unknown etiology. FAS-mediated apoptosis is assumed to prevent the development of PE; therefore FAS and FAS Ligand may be represented as candidate genes involved in PE pathogenesis. In the present study, we evaluated the relation between FAS Ligand A-670G (rs1800682) and FAS Ligand C-844T (rs763110) gene polymorphisms with PE in southeast Iran. Methods: One hundred and twenty-seven unrelated women with PE and 139 healthy control subjects were genotyped for the FAS A-670G and FAS Ligand C-844T polymorphisms by polymerase chain reaction restriction fragment length polymorphism method. Results: The AA, AG and GG genotype frequency of the FAS A-670G polymorphism were 21.3%, 53.5% and 25.2% in pre-eclamptic women and 46.0%, 41.5% and 11.5% in controls and were statistically different (P = 0.0001). The risk of PE was 2.7-and 4.7-fold higher in pregnant women with AG and GG genotypes respectively. Although the frequency TT genotype and T allele of FAS Ligand C-844T gene polymorphism was higher in the PE group, the differences were not significant. Conclusion: FAS A-670G polymorphism is associated with a higher risk for PE. There was no association between FAS Ligand C-844T polymorphism and PE.

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“…They assumed that maternal possession of G allele increases the risk for preeclampsia because having influence on gene expression. Others have shown the association of the rs1800682 G allele with intrauterine growth restriction (Robinson et al 2009). However, recent findings do not support the role of this polymorphism in the pathogenesis of preeclampsia (Polavarapu et al 2013).…”

Section: Introductionmentioning

confidence: 99%

Association of specific diplotypes defined by common rs1800682 and rare rs34995925 single nucleotide polymorphisms within the STAT1 transcription binding site of the FAS gene promoter with preeclampsia

Lasabová

Zigo

Svecova

et al. 2014

gpb

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Abstract. The tolerance of fetal antigens by intradecidual T-cell involving the Fas-mediated apoptosis plays an important role in the physiological course of pregnancy. Objective of this study is to determine the association of diplotypes of common rs1800682 G and rare rs34995925 C alleles within the STAT1 transcription binding site of the FAS promoter region with preeclampsia. There were 116 preeclamptic women and 123 healthy control subjects from Hungary and Slovakia enrolled in the study. The presence of the GG or GA genotypes on rs1800682 was confirmed in 91 patients and 85 controls (OR = 1.628, 95% CI 0.907-2.92). The rare rs34995925 C allele laying 7 bp further from rs1800682 within STAT1 transcription binding site was detected in 3 preeclamptic cases and none healthy subjects. Haplotypes GT and AC were defined by common rs1800682 G and rare rs34995925 C alleles, respectively, and were considered as "low" FAS-producing. The combinations of GT or AC with normal FAS-producing haplotypes AT were considered as "low" FAS-producing diplotypes in dominant model. The "low" FAS-producing diplotype group of GT/GT, GT/AT, and AC/AT compared to the normal FAS-producing diplotype group of AT/AT showed OR = 1.91 (95% CI 1.04-3.48) and p = 0.03 for the association with preeclampsia.

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A Single-Nucleotide Polymorphism (−670) of the Maternal Fas Gene Is Associated With Intrauterine Growth Restriction

Cited by 4 publications

References 0 publications

FAS A‐670G and Fas ligand IVS2nt A 124G polymorphisms are significantly increased in women with pre‐eclampsia and may contribute to HELLP syndrome: a case‐controlled study

FAS A‐670G and Fas ligand IVS2nt A 124G polymorphisms are significantly increased in women with pre‐eclampsia and may contribute to HELLP syndrome: a case‐controlled study

Association of functional polymorphisms in FAS and FASLigand genes promoter with pre‐eclampsia

Association of specific diplotypes defined by common rs1800682 and rare rs34995925 single nucleotide polymorphisms within the STAT1 transcription binding site of the FAS gene promoter with preeclampsia

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A Single-Nucleotide Polymorphism (−670) of the Maternal Fas Gene Is Associated With Intrauterine Growth Restriction

Cited by 4 publications

References 0 publications

FAS A‐670G and Fas ligand IVS2nt A 124G polymorphisms are significantly increased in women with pre‐eclampsia and may contribute to HELLP syndrome: a case‐controlled study

FAS A‐670G and Fas ligand IVS2nt A 124G polymorphisms are significantly increased in women with pre‐eclampsia and may contribute to HELLP syndrome: a case‐controlled study

Association of functional polymorphisms in FAS and FASLigand genes promoter with pre‐eclampsia

Association of specific diplotypes defined by common rs1800682 and rare rs34995925 single nucleotide polymorphisms within the STAT1 transcription binding site of the FAS gene promoter with preeclampsia

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Product

Resources

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Association of specific diplotypes defined by common rs1800682 and rare rs34995925 single nucleotide polymorphisms within the STAT1 transcription binding site of the FAS gene promoter with preeclampsia