A Single Nucleotide Polymorphism in the  Stromal Cell-Derived Factor 1 Gene Is Associated with  Coronary Heart Disease in Chinese Patients

Feng, Lei; Nian, Shiyan; Hao, Yinglu; Xu, Wenbo; Ye, Dan; Zhang, Xingfeng; Li, Dan

doi:10.3390/ijms150611054

Cited by 15 publications

(26 citation statements)

References 25 publications

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“…After different levels of screening, 42 articles were excluded, including 22 articles that were duplicated, 3 articles that did not concern CHD, and 17 articles that did not concern rs1801157. Seven articles were found to be in accordance with the inclusion criteria and were finally included in this meta-analysis 20 21 22 26 27 28 29 .…”

Section: Resultsmentioning

confidence: 99%

“…Several GWASs have confirmed that the rs501120 and rs1746048 polymorphism loci in the SDF-1 gene are associated with the susceptibility to CHD 16 17 , but rs1801157 was not reported in any of the above studies. The cause may be that GWASs cannot identify all of the SNPs involved in a single action, although they could offer a large amount of information on SNPs 20 . Furthermore, because the rs1801157 polymorphism was demonstrated to upregulate the expression of SDF-1 19 , some researchers have suggested that rs1801157 is associated with a decreased risk of CHD 20 26 27 .…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, a newly found SNP locus in the SDF-1 gene (G801A, rs1801157), which has a G-to-A mutation at position 801 in the 3’-untranslated region, has been shown to upregulate the expression of SDF-1 19 . Most importantly, the rs1801157 polymorphism was shown to be linked to the susceptibility to CHD, but discrepancies exist in the Chinese and Caucasian populations 20 21 22 . Therefore, in the present study, we performed a meta-analysis to evaluate the association between the rs1801157 polymorphism in the SDF-1 gene and the risk of CHD.…”

Section: Introductionmentioning

confidence: 99%

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Lack of an Association between the SDF-1 rs1801157 Polymorphism and Coronary Heart Disease: A Meta-Analysis

Zhang

Jia

et al. 2015

Sci Rep

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Recent studies have shown that the single-nucleotide polymorphism (SNP) rs1801157 in the stromal cell-derived factor (SDF)-1 gene is associated with susceptibility to coronary heart disease (CHD). However, published studies have shown inconsistent results. Therefore, a meta-analysis was carried out to evaluate the association between rs1801157 and CHD in the literature. A systematic literature search was performed using the PubMed, Web of Science, Cochrane Library, Chinese National Knowledge Infrastructure and Chinese Wan Fang databases. Heterogeneity and publication bias were also evaluated. Seven eligible studies that involved 4656 cases and 2654 controls were finally included in this meta-analysis. Overall, the results showed that the rs1801157 polymorphism was not statistically associated with the risk of CHD under all genetic models but that rs1801157 was associated with decreased susceptibility to myocardial infarction (MI) in subgroup analyses. Moreover, no association was found between rs1801157 and the susceptibility to CHD in either Caucasians or Asians. In conclusion, our meta-analysis demonstrated that the rs1801157 polymorphism is not associated with the susceptibility to CHD but may be associated with a decreased risk of MI. However, further large-scale, case-control studies with rigorous designs should be conducted to confirm these conclusions.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Lack of an Association between the SDF-1 rs1801157 Polymorphism and Coronary Heart Disease: A Meta-Analysis

Zhang

Jia

et al. 2015

Sci Rep

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“…CHD is a complex disease, involving interactions between environmental and genetic factors (Feng et al, 2014). Previous studies have found that single nucleotide polymorphisms (SNPs), important genomic elements, can affect an individual's genetic susceptibility to various diseases, including CHD Muiya et al, 2014;Wu et al, 2014;Yang et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Lack of an association between matrix metalloproteinase polymorphisms and coronary heart disease in a Han Chinese population

Cm¹,

et al. 2015

Genet. Mol. Res.

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ABSTRACT. Coronary heart disease (CHD) has become a leading cause of human deaths worldwide. Recent studied showed that polymorphisms of the matrix metalloproteinase (MMP) genes played important roles in extracellular matrix remodeling and contribute to the pathogenesis of vascular diseases. Here, we investigated whether these MMP gene polymorphisms were associated with CHD in Han Chinese. Our case-control study was involved with 1509 unrelated individuals, 12255Matrix metalloproteinases and coronary heart disease ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (4): 12254-12261 (2015) including 777 CHD cases and 732 controls. We selected a total of five polymorphisms whose genotypes were determined using Sequenom iPLEX technology. Our results showed there were no significant associations between the five MMP gene polymorphisms and CHD risk at either genotype or allele levels (P > 0.05). Further subgroup analyses by sex were also unable to reveal any significant association (P > 0.05).In conclusion, no significant associations were found between the five MMP gene polymorphisms and the risk of CHD in Han Chinese.

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“…However, the exact mechanism of the disease is still unclear. In recent years, genetic predisposition has been thought to be closely associated with CHD and has been widely studied [5,6].…”

Section: Introductionmentioning

confidence: 99%

Analysis on the polymorphisms of site RS4977574, and RS1333045 in region 9p21 and the susceptibility of coronary heart disease in Chinese population

Liu

Yuan

et al. 2020

BMC Med Genet

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Background: Rs4977574 (A > G) and Rs1333045 (C > T) are both single nucleotide polymorphisms (SNPs) related with coronary artery disease, locating on chromosome 9p21.3. The study aimed to identify the correlation between rs4977574 and rs1333045 polymorphism genotypes and coronary heart disease (CHD) in a Chinese population. Methods: Blood samples were collected from 855 subjects. A case-control study was used in this experiment, and 598 cases in the CHD group and 257 subjects in the control group were enrolled. Genotyping was identified by the Agena MassARRAY system. Statistical analysis was conducted by SPSS (Ver 16.0) and plink (Ver. 1.07, Shaun Purcell). Haplotype analysis was performed using Haploview software. Results: Association analysis by plink indicated a significant difference in the allele distribution for single nucleotide polymorphisms between cases and controls (rs4977574 P = 0.003, rs1333045 P = 0.035). Fisher's exact test by plink proved that allele G may be associated with a higher risk of CHD (P = 0.003, odds ratio (OR) = 1.371) and the T allele was likely to reduce the risk of coronary events (P = 0.035, OR = 0.798). The serum levels of apolipoprotein A (ApoA) were higher in subjects with the AG + AA genotype of rs4977574 compared to those with the GG genotype (P = 0.028). In the dominant model of rs1333045, the levels of ApoA were higher and LDL levels were lower in the TC + TT genotype than in the CC genotype. Conclusions: The present study examined the association between the 9p21 chromosome rs4977574 and rs1333045 polymorphism genotypes and CHD in a population of Chinese patients. The G allele of rs4977574 and the C allele of rs1333045 are the susceptibility sites of CHD.

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A Single Nucleotide Polymorphism in the Stromal Cell-Derived Factor 1 Gene Is Associated with Coronary Heart Disease in Chinese Patients

Cited by 15 publications

References 25 publications

Lack of an Association between the SDF-1 rs1801157 Polymorphism and Coronary Heart Disease: A Meta-Analysis

Lack of an Association between the SDF-1 rs1801157 Polymorphism and Coronary Heart Disease: A Meta-Analysis

Lack of an association between matrix metalloproteinase polymorphisms and coronary heart disease in a Han Chinese population

Analysis on the polymorphisms of site RS4977574, and RS1333045 in region 9p21 and the susceptibility of coronary heart disease in Chinese population

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