A single session of prefrontal cortex transcranial direct current stimulation does not modulate implicit task sequence learning and consolidation

Savic, Branislav; Müri, René M.; Meier, Beat

doi:10.1016/j.brs.2017.01.001

Cited by 20 publications

(13 citation statements)

References 48 publications

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“…Previous studies have shown that learning remained stable or even improved across sessions 16 – 22 . In line with these results, our previous study 6 showed that memory traces of task sequences were stable across sessions.…”

Section: Introductionsupporting

confidence: 81%

“…Recent results showed that DLPFC tDCS does not influence implicit task sequence learning and consolidation when a task sequence learning paradigm was performed bimanually 6 . As bimanual task performance requires the coupling between homologous cortical regions of the hemispheres and, because the left and the right DLPFC were stimulated one at the time, the null findings could have been provoked by the bimanual set-up of the task.…”

Section: Discussionmentioning

confidence: 99%

“… 13 , 27 , cf. 6 . Participants were presented with two kinds of stimuli: digits (1, 2, 3, 4, 6, 7, 8, and 9) or letters (a, e, i, u, c, n, r, and s).…”

Section: Methodsmentioning

confidence: 99%

“…However, since these effects are variable further understanding of prefrontal cortex stimulation is needed 4 , 5 . Indeed, in a recent study, we have found no effects of dorsolateral prefrontal cortex (DLPFC) stimulation in a task in which patients with DLPFC lesions were strongly impaired 6 . In that study, implicit task sequence learning was investigated with a paradigm that involved bimanual responses.…”

Section: Introductionmentioning

confidence: 94%

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No effects of transcranial DLPFC stimulation on implicit task sequence learning and consolidation

Savic

Cazzoli²,

Müri³

et al. 2017

Sci Rep

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Neurostimulation of the dorsolateral prefrontal cortex (DLPFC) can modulate performance in cognitive tasks. In a recent study, however, transcranial direct current stimulation (tDCS) of the DLPFC did not affect implicit task sequence learning and consolidation in a paradigm that involved bimanual responses. Because bimanual performance increases the coupling between homologous cortical areas of the hemispheres and left and right DLPFC were stimulated separately the null findings may have been due to the bimanual setup. The aim of the present study was to test the effect of neuro-stimulation on sequence learning in a uni-manual setup. For this purpose two experiments were conducted. In Experiment 1, the DLPFC was stimulated with tDCS. In Experiment 2 the DLPFC was stimulated with transcranial magnetic stimulation (TMS). In both experiments, consolidation was measured 24 hours later. The results showed that sequence learning was present in all conditions and sessions, but it was not influenced by stimulation. Likewise, consolidation of sequence learning was robust across sessions, but it was not influenced by stimulation. These results replicate and extend previous findings. They indicate that established tDCS and TMS protocols on the DLPFC do not influence implicit task sequence learning and consolidation.

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Section: Introductionsupporting

confidence: 81%

Section: Discussionmentioning

confidence: 99%

“… 13 , 27 , cf. 6 . Participants were presented with two kinds of stimuli: digits (1, 2, 3, 4, 6, 7, 8, and 9) or letters (a, e, i, u, c, n, r, and s).…”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 94%

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No effects of transcranial DLPFC stimulation on implicit task sequence learning and consolidation

Savic

Cazzoli²,

Müri³

et al. 2017

Sci Rep

Self Cite

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“…Several attempts have been made to improve sleep-dependent memory consolidation with transcranial electric stimulation (TES). The initial studies reported promising results [14][15][16], but more recently, the findings were mixed [17][18][19][20].…”

Section: Introductionmentioning

confidence: 99%

Bi-temporal anodal tDCS during slow-wave sleep boosts episodic memory consolidation in high performers

Grieder¹,

Morishima²,

Winkelbeiner³

et al. 2019

Preprint

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Background: Sleep is crucial for sound memory functioning in humans. In particular, the slow waves that occur predominantly during slow wave sleep (SWS) are associated with hippocampus-dependent declarative memory consolidation. Making use of this association, boosting SWS to improve memory performance would be appealing for both healthy and memory-impaired populations. Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation that modulates the brain’s excitability and has shown promising results in improving memory performance. However, owing to differing stimulation protocols and contradictory findings, there is insufficient evidence for the efficacy of tDCS-modulated hippocampal excitability on SWS and sleep-dependent memory consolidation.Hypotheses: We aimed to enhance sleep-dependent memory consolidation and augment slow wave amplitudes.Methods: We applied bi-temporal anodal tDCS to the left and right lateral temporal lobes of 31 healthy participants in a double-blind, sham-controlled, randomized crossover study. State-dependent tDCS was administered during slow wave sleep only. A pair-associate episodic memory task was used to assess sleep-dependent memory consolidation with face-occupation stimuli with baseline retrieval before sleep and delayed retrieval after sleep.Results: Sleep-dependent memory consolidation was increased by tDCS only in participants who showed above-average performance (i.e. high performers) in baseline memory retrieval. Moreover, tDCS increased the slow wave amplitudes compared to sham.Conclusions: When targeting a specialized brain mechanism such as memory consolidation with tDCS during slow wave sleep, only those who were high performers at baseline achieved a memory boost.

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Modulating Cognition in Healthy Young Adults with tDCS

Habich

Fehér

Harty

et al. 2021

Transcranial Direct Current Stimulation in Neuropsychiatric Disorders

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A single session of prefrontal cortex transcranial direct current stimulation does not modulate implicit task sequence learning and consolidation

Cited by 20 publications

References 48 publications

No effects of transcranial DLPFC stimulation on implicit task sequence learning and consolidation

No effects of transcranial DLPFC stimulation on implicit task sequence learning and consolidation

Bi-temporal anodal tDCS during slow-wave sleep boosts episodic memory consolidation in high performers

Modulating Cognition in Healthy Young Adults with tDCS

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