With great significance in military and civilian applications, the topic of detecting small and densely arranged objects in wide-scale remote sensing imagery is still challenging nowadays. To solve this problem, we propose a novel effectively optimized one-stage network (NEOON). As a fully convolutional network, NEOON consists of four parts: Feature extraction, feature fusion, feature enhancement, and multi-scale detection. To extract effective features, the first part has implemented bottom-up and top-down coherent processing by taking successive down-sampling and up-sampling operations in conjunction with residual modules. The second part consolidates high-level and low-level features by adopting concatenation operations with subsequent convolutional operations to explicitly yield strong feature representation and semantic information. The third part is implemented by constructing a receptive field enhancement (RFE) module and incorporating it into the fore part of the network where the information of small objects exists. The final part is achieved by four detectors with different sensitivities accessing the fused features, all four parallel, to enable the network to make full use of information of objects in different scales. Besides, the Focal Loss is set to enable the cross entropy for classification to solve the tough problem of class imbalance in one-stage methods. In addition, we introduce the Soft-NMS to preserve accurate bounding boxes in the post-processing stage especially for densely arranged objects. Note that the split and merge strategy and multi-scale training strategy are employed in training. Thorough experiments are performed on ACS datasets constructed by us and NWPU VHR-10 datasets to evaluate the performance of NEOON. Specifically, 4.77% and 5.50% improvements in mAP and recall, respectively, on the ACS dataset as compared to YOLOv3 powerfully prove that NEOON can effectually improve the detection accuracy of small objects in remote sensing imagery. In addition, extensive experiments and comprehensive evaluations on the NWPU VHR-10 dataset with 10 classes have illustrated the superiority of NEOON in the extraction of spatial information of high-resolution remote sensing images.