“…Several analytical methods have been reported in the literature for determining CIP and NOR in pharmaceutical formulations and/or biologic fluids using techniques such as spectrophotometry, 6,7 charge transfer complex formation, 8,9 derivative UV spectrophotometry, 10,11 high performance liquid chromatography, 12,13 capillary electrophoresis, [14][15][16] fluorescence, 17 immunoassay, 18 flow injection analysis, [19][20][21][22] and SIA. 23 However, many of these methods present low selectivity, 10,11 are time-consuming, 6,7,9 involving the use of organic solvents 8,9,12,17 or require expensive instruments [12][13][14][15][16][17][18] and for these reasons they are not suitable for routine analysis.…”