A single-tablet fixed-dose combination of racemic ibuprofen/paracetamol in the management of moderate to severe postoperative dental pain in adult and adolescent patients: A multicenter, two-stage, randomized, double-blind, parallel-group, placebo-controlled, factorial study

Mehlisch, Donald R.; Aspley, Sue; Daniels, Stephen E.; Southerden, Kristin A.; Christensen, Kyle S.

doi:10.1016/j.clinthera.2010.06.002

Cited by 66 publications

(47 citation statements)

References 13 publications

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“…The dental pain model is widely used to evaluate the effectiveness of analgesic agents. This model is characterized by localized pain that is predictable in its nature, duration (3-5 days) and intensity (moderate to severe) 18 .…”

Section: Discussionmentioning

confidence: 99%

Analgesic effectiveness of prophylactic therapy and continued therapy with naproxen sodium post simple extraction.

et al. 2015

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Section: Discussionmentioning

confidence: 99%

Analgesic effectiveness of prophylactic therapy and continued therapy with naproxen sodium post simple extraction.

et al. 2015

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“…The maximum achievable score of 16 took cognisance of whether teeth were erupted and whether impaction involved soft tissue, partial bone, complete bone or unusual impaction such as horizontal/ inverted or posterior/anterior. 18 All patients required bone removal for two mandibular impacted molars. Not surprisingly, all enrolled patients experienced moderate to severe post-operative pain and were therefore eligible for inclusion in the study.…”

Section: Discussionmentioning

confidence: 99%

“…18 The study was approved by the University of Pretoria Research Ethics Committee (236/2112) and was registered with NHREC (DOH-27-0313-4234). The Medicines Control Council was also notified.…”

Section: Methodsmentioning

confidence: 99%

A randomised clinical trial comparing the analgesic and anxiolytic efficacy and tolerability of Stilpane® and Tramacet® after third molar extraction

Outhoff

Dippenaar

Nell

et al. 2015

Southern African Journal of Anaesthesia and Analgesia

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“…Dose-response curves for the combination therapy in adults suffering dental pain have been published [81]. Analysis of those data using a response surface area allowed dose interpretation in children [82 • ].…”

Section: Acetaminophen-ibuprofenmentioning

confidence: 99%

Unraveling Pharmacokinetics and Pharmacodynamics in Infants and Children

Sumpter¹,

Anderson

2012

Curr Anesthesiol Rep

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Our knowledge of the pharmacology of the drugs used in pediatric anesthesia has advanced with a greater understanding of their pharmacokinetics (PK) and pharmacodynamics. This has resulted in a refinement of their uses, broader indications, and alternative methods of delivery. For example, methadone is becoming increasingly popular for spinal surgery, the dosing of etomidate has been clarified and the PK of intravenous acetaminophen from neonates to adults has been revealed. Morphine PK have also been clarified, although pharmacodynamic ethnic differences remain unexplained. The optimal size descriptor to predict correct drug doses in the obese remains controversial. Efforts to reduce adverse effects of individual drugs have spawned investigations into beneficial drug interactions, although combinations such as propofol and ketamine await PK and safety review. The nasal route may be a reasonable alternative to intravenous administration for many drugs. Oral ketamine may serve as a valuable premedication for children suffering burns. Expanded indications can have unfavorable consequences; propofol may cause profound hypotension in neonates.

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A single-tablet fixed-dose combination of racemic ibuprofen/paracetamol in the management of moderate to severe postoperative dental pain in adult and adolescent patients: A multicenter, two-stage, randomized, double-blind, parallel-group, placebo-controlled, factorial study

Cited by 66 publications

References 13 publications

Analgesic effectiveness of prophylactic therapy and continued therapy with naproxen sodium post simple extraction.

Analgesic effectiveness of prophylactic therapy and continued therapy with naproxen sodium post simple extraction.

A randomised clinical trial comparing the analgesic and anxiolytic efficacy and tolerability of Stilpane® and Tramacet® after third molar extraction

Unraveling Pharmacokinetics and Pharmacodynamics in Infants and Children

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