A single transcription factor promotes both yield and immunity in rice

Wang, Jing; Zhou, Lian; Shi, Hui; Chern, Mawsheng; Yu, Hong; Yi, Hong; He, Min; Yin, Junjie; Zhu, Xiaobo; Li, Yan; Li, Weitao; Liu, Jiali; Chen, Xiaoqiong; Qing, Hai; Wang, Yuping; Liu, Guifu; Wang, Wenming; Li, Ping; Wu, Xiaoyun; Zhu, Lihuang; Zhou, Jian‐Min; Ronald, Pamela C.; Li, Shigui; Li, Jiayang; Chen, Xuewei

doi:10.1126/science.aat7675

Cited by 332 publications

(272 citation statements)

References 27 publications

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“…Putative costs of plant defenses on growth have been intensively researched, and recent findings are suggesting that it is possible to promote one without sacrificing the other (C ampos et al 2016; W ang et al 2018). Our current study further brightens the future potential to optimize plant growth and defense through TF manipulation.…”

Section: Discussionmentioning

confidence: 99%

“…Further, diminutive constitutive defense mutants can have their growth rescued by second site mutations that maintain the constitutive defense (10-15). Specific TFs are also being identified that can simultaneously increase growth and specific defenses (14, 16). Together, these observations suggest that the relationship between plant defense and growth is an active internal decision process involving regulatory and signaling pathways in planta and not a rigid process driven by limitations of elements and energy (17).…”

Section: Introductionmentioning

confidence: 99%

“…Further, diminutive constitutive defense mutants can have their growth rescued by second site mutations that maintain the constitutive defense (H emm et al 2003; P aul -V ictor et al 2010; Z üst et al 2011; J oseph et al 2013; C ampos et al 2016; K liebenstein 2016). Specific TFs are also being identified that can simultaneously increase growth and specific defenses (C ampos et al 2016; W ang et al 2018). Together, these observations suggest that the relationship between plant defense and growth is a complex and active internal decision process involving regulatory and signaling pathways in planta (Z ust and A grawal 2017).…”

Section: Introductionmentioning

confidence: 99%

“…Mutations of JAZ s, transcriptional repressors in jasmonic acid (JA) signaling pathway, in combination with altered photoreceptor PhyB results in fast-growing plants with enhanced plant defense responses (C ampos et al 2016). A rice TF, Ideal Plant Architecture 1 (IPA) , was previously cloned and characterized to activate yield-related genes and promote the high yield (J iao et al 2010), and recently further shown to promote both plant defense and rice yield simultaneously (W ang et al 2018). These case studies demonstrated that growth and defense are under complex regulation and TFs are key integrators that coordinate these two important biological processes.…”

Section: Introductionmentioning

confidence: 99%

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Epistatic Transcription Factor Networks Differentially Modulate Arabidopsis Growth and Defense

Tang

Caseys

et al. 2019

Preprint

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Plants integrate internal and external signals to finely coordinate growth and defense allowing for maximal fitness within a complex environment. One common model for the relationship between growth and defense is a trade-off model in which there is a simple negative interaction between growth and defense theoretically driven by energy costs. However, there is a developing consensus that the coordination of growth and defense likely involves a more conditional and intricate connection. To explore how a transcription factor network may coordinate growth and defense, we used high-throughput phenotyping to measure growth and flowering in a set of single and pairwise mutants previously linked to the aliphatic glucosinolate defense pathway. Showing the link between growth and aliphatic glucosinolate defense, 17 of the 20 tested TFs significantly influence plant growth and/or flowering time. These effects were conditional upon the environment, age of the plant and more critically varied amongst the phenotypes when using the same genotype. The phenotypic effects of the TF mutants on SC GLS accumulation and on growth were not correlated, which indicating that there is not a simple energetic trade-off for growth and defense. We propose that large transcription factor networks create a system to integrate internal and external signals and separately modulate growth and defense traits. Significant StatementThe relationship between plant growth and plant defense is critical to understanding plant fitness or yield and is often described as a simple trade-off model. However, this model is under extensive research and is a highly debated research topic. We used a large-scale phenotyping approach to study the dynamics of plant growth in a transcriptional factor (TF) mutant population in the model plant Arabidopsis that regulates the defense pathway, aliphatic glucosinolates (GLS). We showed that these TFs have significant effects on plant growth that is heavily influenced by epistasis and the environment. Critically, the effects of these TFs on growth and defense were largely independent and had little evidence supporting a simple trade off model. Instead, we propose that the TFs independently coordinate plant growth and plant defense. As our study tested a fraction of the total potential TFs influencing growth, our findings indicate that there is high potential to use TFs to promote both plant growth and defense simultaneously for modern agriculture in the ever-changing environment.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Epistatic Transcription Factor Networks Differentially Modulate Arabidopsis Growth and Defense

Tang

Caseys

et al. 2019

Preprint

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“…This shift in specificity allows the protein to bind to and activate WRKY45, a defence regulatory transcription factor, providing quantitative resistance. By contrast, nonphosphorylated IPA1 promotes the expression of at least one yield-related gene (Wang et al, 2018b). If this posttranslational regulation is conserved, IPA1 expression may be useful to control disease in other crops.…”

Section: Reviewmentioning

confidence: 99%

Genetic modification to improve disease resistance in crops

2019

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Summary Plant pathogens are a significant challenge in agriculture despite our best efforts to combat them. One of the most effective and sustainable ways to manage plant pathogens is to use genetic modification (GM) and genome editing, expanding the breeder's toolkit. For use in the field, these solutions must be efficacious, with no negative effect on plant agronomy, and deployed thoughtfully. They must also not introduce a potential allergen or toxin. Expensive regulation of biotech crops is prohibitive for local solutions. With 11–30% average global yield losses and greater local impacts, tackling plant pathogens is an ethical imperative. We need to increase world food production by at least 60% using the same amount of land, by 2050. The time to act is now and we cannot afford to ignore the new solutions that GM provides to manage plant pathogens.

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Stalk Strength Improvement in Crop Plants: A Progress Report

Multani

Jiao

Jung

et al. 2021

Annual Plant Reviews Online

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Stalk lodging is one of the serious problems in all cereal crops that can result in enormous yield loss. Severe stalk lodging interferes with mechanical harvest resulting in loss of grain. The genetics of stalk strength is complex and in most crops the trait is controlled by multiple minor quantitative trait loci (QTLs). Screening for stalk strength is not only variable from crop to crop because of variable stalk structures but also time consuming and has reproducibility issues. A series of mutants including brittle culm in rice and brittle stalk in maize have been isolated. Similarly, potential candidate genes showing close association with genes involved in the biosynthesis of cell wall components like cellulose and lignin have been cloned in rice, maize, barley, and Arabidopsis. Several QTLs for stalk strength have been mapped in maize, rice, canola, and soybean using GWAS and genomic selection approaches. To our knowledge, candidate genes for only two QTLs have been cloned by map‐based cloning approaches including stiff1 in maize and SCM2 in rice. So far, transgenic approaches such as overexpression of the candidate gene, gene silencing, and genome editing have been used only for candidate gene validation and not for any crop development. However, novel beneficial alleles identified by allele mining or generated by transgene/gene editing approaches may be combined through marker‐assisted selection (MAS) to supplement the conventional breeding process for improving stalk strength and lodging resistance. In this article, we review the published information on stalk strength and update its status in crop plants.

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A single transcription factor promotes both yield and immunity in rice

Cited by 332 publications

References 27 publications

Epistatic Transcription Factor Networks Differentially Modulate Arabidopsis Growth and Defense

Epistatic Transcription Factor Networks Differentially Modulate Arabidopsis Growth and Defense

Genetic modification to improve disease resistance in crops

Stalk Strength Improvement in Crop Plants: A Progress Report

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