A sintered graphene/titania material as a synthetic keratoprosthesis skirt for end-stage corneal disorders

Zhong, Li; Goh, Tze-Wei; Yam, Gary Hin‐Fai; Thompson, Brianna C.; Hu, Huanlong; Setiawan, Melina; Riau, Andri K.; Tan, Donald; Khor, Khiam Aik

doi:10.1016/j.actbio.2019.05.053

Cited by 11 publications

(7 citation statements)

References 48 publications

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“…In addition, in the complex in vivo environment, the protective and restorative cells (such as immune cells) might protect the eyes against external irritation and mitigate or repair potential injury [39,40]. Previous studies have also consistently demonstrated that GO-based nanomaterials have good in vivo biocompatibility with ocular surface and inner eyes [17][18][19][20][21].…”

Section: Discussionmentioning

confidence: 99%

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Effects of the Surface Charge of Graphene Oxide Derivatives on Ocular Compatibility

Rong

Fu²,

et al. 2022

Nanomaterials

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The incorporation of functional groups endows graphene oxide (GO) with different surface charges, which plays important roles in biological interactions with cells. However, the effect of surface charge of GO derivatives on ocular biocompatibility has not been fully elucidated. Previously, we found that positively, negatively and neutrally charged PEGylated GO (PEG-GO) nanosheets exerted similar effect on the viability of ocular cells. In this work, we performed in vitro and in vivo studies to comprehensively study the effect of surface charge of PEG-GO on ocular compatibility. The in vitro results showed that the cellular uptake efficacy of negatively charged PEG-GO nanosheets was significantly decreased compared with positively charged and neutrally charged analogs. However, three kinds of PEG-GO nanosheets produced similar amounts of intracellular reactive oxygen species and showed similar influence on mitochondrial membrane potential. By analysis of global gene expression profiles, we found that the correlation coefficients between three kinds of PEG-GO-treated cells were more than 0.98. Furthermore, in vivo results showed that all these PEG-GO nanosheets had no significant toxicity to ocular structure and function. Taken together, our work suggested that surface charge of PEG-GO exerted negligible effect on its ocular compatibility, except for the cellular uptake. Our work is conducive to understanding the relationship between surface charge and biocompatibility of GO derivatives.

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Section: Discussionmentioning

confidence: 99%

“…In recent years, extensive studies have shown that GO-based nanomaterials hold great potential application in the ocular surface and intraocular diseases [ 17 , 18 , 19 , 20 , 21 ]. As a result, it is increasingly important to comprehensively evaluate the ocular toxicity of GO derivatives.…”

Section: Introductionmentioning

confidence: 99%

Effects of the Surface Charge of Graphene Oxide Derivatives on Ocular Compatibility

Rong

Fu²,

et al. 2022

Nanomaterials

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“…114 Sintered nanocomposites of titanium dioxide (TiO 2 ) reinforced by different GO structures have been tested. In 2019, Li et al 115 reported incorporating GO nanoparticles and liquid crystalline GO, in both the natural and reduced state, into TiO 2 matrices. These nanocomposites with GO in the reduced state were safer and more biocompatible than pure TiO 2 .…”

Section: Graphene Oxidementioning

confidence: 99%

Application of biomaterials and nanotechnology in corneal tissue engineering

Soleimani,

Ebrahimi,

Ebrahimi

et al. 2023

J Int Med Res

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Corneal diseases are among the most common causes of blindness worldwide. Regardless of the etiology, corneal opacity- or globe integrity-threatening conditions may necessitate corneal replacement procedures. Several procedure types are currently available to address these issues, based on the complexity and extent of injury. Corneal allograft or keratoplasty is considered to be first-line treatment in many cases. However, a significant proportion of the world’s population are reported to have no access to this option due to limitations in donor preparation. Thus, providing an appropriate, safe, and efficient synthetic implant (e.g., artificial cornea) may revolutionize this field. Nanotechnology, with its potential applications, has garnered a lot of recent attention in this area, however, there is seemingly a long way to go. This narrative review provides a brief overview of the therapeutic interventions for corneal pathologies, followed by a summary of current biomaterials used in corneal regeneration and a discussion of the nanotechnologies that can aid in the production of superior implants.

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“…The circulatory system then distributes them to different parts of the body. Kreyling et al studied the biokinetics and clearance of 48 V-radiolabeled, pure TiO 2 ([ 48 V]TiO 2 NP) anatase nanoparticles by injecting them intravenously into female Wistar rats. The analysis presented higher accumulation in the liver (95.5% after one day), spleen (2.5%), carcass (1%), skeleton (0.7%), and blood (0.4%) while a detectable quantity of nanoparticles was found in all other organs.…”

Section: Review Effect Of Physicochemical Properties Of Tio 2 On Bioc...mentioning

confidence: 99%

Engineered titania nanomaterials in advanced clinical applications

Sahare¹,

Alvarez²,

Yanez³

et al. 2022

Beilstein J. Nanotechnol.

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Significant advancement in the field of nanotechnology has raised the possibility of applying potent engineered biocompatible nanomaterials within biological systems for theranostic purposes. Titanium dioxide (titanium(IV) oxide/titania/TiO2) has garnered considerable attention as one of the most extensively studied metal oxides in clinical applications. Owing to the unique properties of titania, such as photocatalytic activity, excellent biocompatibility, corrosion resistance, and low toxicity, titania nanomaterials have revolutionized therapeutic approaches. Additionally, titania provides an exceptional choice for developing innovative medical devices and the integration of functional moieties that can modulate the biological responses. Thus, the current review aims to present a comprehensive and up-to-date overview of TiO2-based nanotherapeutics and the corresponding future challenges.

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A sintered graphene/titania material as a synthetic keratoprosthesis skirt for end-stage corneal disorders

Cited by 11 publications

References 48 publications

Effects of the Surface Charge of Graphene Oxide Derivatives on Ocular Compatibility

Effects of the Surface Charge of Graphene Oxide Derivatives on Ocular Compatibility

Application of biomaterials and nanotechnology in corneal tissue engineering

Engineered titania nanomaterials in advanced clinical applications

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