A six-year study of leiomyomata with emphasis on lipoleiomyoma

Abstract

Background: Leiomyoma is the most common benign neoplasm of the uterus. Lipoleiomyoma is a rare variant usually affecting women in the postmenopausal age group. Incidence of lipoleiomyoma varies from 0.59% - 2.1%. This study was undertaken to analyse the different variants, degenerative changes and to determine the incidence, clinical and morphological features of lipoleiomyoma amongst all the leiomyomas studied.Methods: This study was done in the Department of Pathology over a period of 6 years. Authors studied 575 patients with leiomyoma constituting a total of 1122 leiomyomata as some patients presented with multiple leiomyomata. Further clinicopathological correlation was done.Results: In the present study 98.03% of leiomyomata were uterine in location, 1.06% were cervical, 0.62% were in broad ligament and 0.26 % were in ovary. Among the 1122 leiomyomata studied, degenerative changes were noted in 19.6% of which hyaline degeneration was the most common. Leiomyoma variants constituted 5.27% of all leiomyomata. The incidence of lipoleiomyoma was 0.71% with size ranging from 3-10cm.Conclusions: Leiomyoma is a common tumor of the uterus and lipoleiomyoma variant is very uncommon with unknown etiology. They occur in postmenopausal as well as reproductive age group. The site of lipoleiomyoma can be uterine or extrauterine location such as broad ligament. Coexistance of metabolic derangement is an observation that may have a role in development of lipoleiomyoma.

A rare case of uterine lipo-leiomyoma in a 63-year-old Nigerian woman; a case report

“…Mostly asymptomatic, lipo-leiomyoma does not have unique symptomatology. Usually, its presentation when symptomatic overlaps those of uterine leiomyoma with symptoms such as pain in the pelvic region, constipation, unusual vaginal bleeding, abdominal discomfort, or increased frequency of urination seen (3,8). In the index case, our patient presented with a year's history of pelvic heaviness and pain, abdominal distension, post-menopausal vaginal bleeding, and uterine mass.…”

“…It was previously considered to be a hamartoma, choristoma, connective tissue degeneration, and fatty metamorphosis. It is now regarded as a distinct pathological entity and a variant of uterine leiomyoma (2,3). Lipo-leiomyoma is extremely unwonted, accounting for only about 0.03%-0.2% of uterine tumours (4).…”

“…Presentation ranges from lack of symptoms to menstrual disturbances, abdominal and/or pelvic pain, a palpable mass, urinary frequency, incontinence, and a sensation of pressure (1). Its commonest location is in the uterine corpus; however, the cervix broad ligament, retroperitoneum, and ovary can also be involved (3). It can be intramural, subserosal or submucosal (3).…”

“…Its commonest location is in the uterine corpus; however, the cervix broad ligament, retroperitoneum, and ovary can also be involved (3). It can be intramural, subserosal or submucosal (3). Like uterine leiomyoma, the aetiology of lipoleiomyoma is unclear.…”