2015
DOI: 10.1016/j.ijpp.2015.07.001
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A skeletal case of hypertrophic osteoarthropathy from the Canary Islands dating from 1000 BP

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Cited by 9 publications
(5 citation statements)
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“…Furthermore, 40% of patients show absorption of terminal phalanges on radiology 8 , resulting from the expression of a phosphateregulating gene with homologies to endopeptidase on the X chromosome (PHEX) that facilitates suppression by M. leprae in osteoblasts 9 . Other authors, however, have reported nding bone formation in patients with leprosy 10 . Tolllike receptor (TLR)1 and TLR4 polymorphisms are associated with protection against leprosy 11,12 , and mineralizationrelated protein is elevated in the condition 13 .…”
Section: Introductionmentioning
confidence: 91%
“…Furthermore, 40% of patients show absorption of terminal phalanges on radiology 8 , resulting from the expression of a phosphateregulating gene with homologies to endopeptidase on the X chromosome (PHEX) that facilitates suppression by M. leprae in osteoblasts 9 . Other authors, however, have reported nding bone formation in patients with leprosy 10 . Tolllike receptor (TLR)1 and TLR4 polymorphisms are associated with protection against leprosy 11,12 , and mineralizationrelated protein is elevated in the condition 13 .…”
Section: Introductionmentioning
confidence: 91%
“…As Fennel and Trinkaus established, the bilateral periostitis present on the femurs and tibiae of LF1 is consistent with HOA [ 7 ]. Researchers have used similar radiological techniques to identify HOA-afflicted human remains from 1970 [ 9 ], medieval England [ 10 ], the Canary Islands roughly a millennium old [ 11 ], and Iron Age civilization [ 12 ]. While it is impossible to fully determine the diagnosis of secondary HOA, given that LF1 displays no soft tissue preservation, it appears highly likely that LF1 did experience this syndrome from an underlying pathology, theorized by Fennel and Trinkaus to be either a thoracic infection or a carcinoma [ 7 ].…”
Section: Reviewmentioning
confidence: 99%
“…Healthcare behaviors can be traced even earlier - H. habilis from 2.4-1.6 million years before the present day often have evidence of deep grooves in their teeth, and wood fragments present in their dental calculus, possibly from the use of makeshift toothpicks to treat periodontal disease [ 18 ]. Many Neanderthal teeth express the same pattern of interproximal grooves, indicating dental probing [ 5 , 11 ]. In addition to this, the Neanderthals may have even used medicinal plants.…”
Section: Reviewmentioning
confidence: 99%
“…leprae in osteoblasts [ 9 ]. Other authors, however, have reported finding bone formation in patients with leprosy [ 10 ]. Toll-like receptor (TLR)1 and TLR4 polymorphisms are associated with protection against leprosy [ 11 , 12 ], and mineralization-related protein is elevated in the condition [ 13 ].…”
Section: Introductionmentioning
confidence: 99%