2015
DOI: 10.3906/biy-1411-5
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A small intron of Drosophila gamma carboxylase, not predictable in silico for mammalian splicing machinery, is spliced improperly in human cells

Abstract: IntroductionMost eukaryotic protein-coding genes are interrupted by introns, which must be precisely removed from the transcript precursor in order to produce functional mRNAs (Gilbert, 1978). This phenomenon, which is commonly referred to as the premRNA splicing process, occurs through the formation of spliceosome (Nilsen, 2003). Recognition of a splice site (ss) by a spliceosome complex takes place via either intron-or exon-definition splicing mechanisms

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