A Small-Scale Survey of Hantavirus in Mammals From Indiana

Dietrich, Nanette; Pruden, Shaina; Ksiazek, Thomas G.; Morzunov, Sergey P.; Camp, Joseph W.

doi:10.7589/0090-3558-33.4.818

Cited by 5 publications

(4 citation statements)

References 19 publications

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“…Rodent samples from West Virginia were kindly provided by Richard Yanagihara. P. leucopus samples used for amplification of the entire hantavirus M RNA genome segments were collected in La Porte County, Indiana (11), and Murray County, Oklahoma. DNA samples used for reconstructing rodent phylogeny included 49 P. leucopus samples from Arkansas, District of Columbia, Georgia, Illinois, Indiana, Iowa, Kansas, Kentucky, Maine, Maryland, Massachusetts, Missouri, New York, North Carolina, North Dakota, Ohio, Oklahoma, Pennsylvania, Rhode Island, South Carolina, Tennessee, Texas, Virginia, West Virginia, and Wisconsin.…”

Section: Methodsmentioning

confidence: 99%

Genetic Analysis of the Diversity and Origin of Hantaviruses in Peromyscus leucopus Mice in North America

Morzunov

Rowe

Ksiazek

et al. 1998

J Virol

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140

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Nucleotide sequences were determined for the complete M genome segments of two distinct hantavirus genetic lineages which were detected in hantavirus antibody- and PCR-positive white-footed mice (Peromyscus leucopus) from Indiana and Oklahoma. Phylogenetic analyses indicated that although divergent from each other, the virus lineages in Indiana and Oklahoma were monophyletic and formed a newly identified unique ancestral branch within the clade of Sin Nombre-like viruses found in Peromyscus mice. Interestingly, P. leucopus-borne New York virus was found to be most closely related to the P. maniculatus-borne viruses, Sin Nombre and Monongahela, and monophyletic with Monongahela virus. In parallel, intraspecific phylogenetic relationships ofP. leucopus were also determined, based on the amplification, sequencing, and analysis of the DNA fragment representing the replication control region of the rodent mitochondrial genome. P. leucopus mitochondrial DNA haplotypes were found to form four separate genetic clades, referred to here as Eastern, Central, Northwestern, and Southwestern groups. The distinct Indiana and Oklahoma virus lineages were detected in P. leucopus of the Eastern and Southwestern mitochondrial DNA haplotypes, respectively. Taken together, our current data suggests that both cospeciation of Peromyscus-borne hantaviruses with their specific rodent hosts and biogeographic factors (such as allopatric migrations, geographic separation, and isolation) have played important roles in establishment of the current genetic diversity and geographic distribution of Sin Nombre-like hantaviruses. In particular, the unusual position of New York virus on the virus phylogenetic tree is most consistent with an historically recent host-switching event.

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Section: Methodsmentioning

confidence: 99%

Genetic Analysis of the Diversity and Origin of Hantaviruses in Peromyscus leucopus Mice in North America

Morzunov

Rowe

Ksiazek

et al. 1998

J Virol

Self Cite

140

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“…Meadow jumping mice have a low parasite load [15], and Zapus species are not known to be vectors for zoonotic diseases including Hantavirus [36,37]. However, standard precautions were taken during field work and the initial stages of animal husbandry because Peromyscus spp.…”

Section: Plos Onementioning

confidence: 99%

Breeding and hibernation of captive meadow jumping mice (Zapus hudsonius)

2021

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Hibernating mammals exhibit unique metabolic and physiological phenotypes that have potential applications in medicine or spaceflight, yet our understanding of the genetic basis and molecular mechanisms of hibernation is limited. The meadow jumping mouse, a small North American hibernator, exhibits traits–including a short generation time–that would facilitate genetic approaches to hibernation research. Here we report the collection, captive breeding, and laboratory hibernation of meadow jumping mice. Captive breeders in our colony produced a statistically significant excess of male offspring and a large number of all-male and all-female litters. We confirmed that short photoperiod induced pre-hibernation fattening, and cold ambient temperature facilitated entry into hibernation. During pre-hibernation fattening, food consumption exhibited non-linear dependence on both body mass and temperature, such that food consumption was greatest in the heaviest animals at the coldest temperatures. Meadow jumping mice exhibited a strong circadian rhythm of nightly activity that was disrupted during the hibernation interval. We conclude that it is possible to study hibernation phenotypes using captive-bred meadow jumping mice in a laboratory setting.

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“…Meadow jumping mice have a low parasite load [15], and Zapus species are not known to be vectors for zoonotic diseases including Hantavirus [33,34]. However, standard precautions were taken during field work and the initial stages of animal husbandry because Peromyscus spp.…”

Section: Trapping and Health Assessmentmentioning

confidence: 99%

Breeding and hibernation of captive meadow jumping mice (Zapus hudsonius)

Brem

McNulty

Israelsen

2020

Preprint

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Hibernating mammals exhibit unique metabolic and physiological phenotypes that have potential applications in medicine or spaceflight, yet our understanding of the genetic basis and molecular mechanisms of hibernation is limited. The meadow jumping mouse, a small North American hibernator, exhibits traits – including a short generation time – that would facilitate genetic approaches to hibernation research. Here we report the collection, captive breeding, and laboratory hibernation of meadow jumping mice. Captive breeders in our colony produced a statistically significant excess of male offspring and a large number of all-male and all-female litters. We confirmed that short photoperiod induced pre-hibernation fattening, and cold ambient temperature facilitated entry into hibernation. During pre-hibernation fattening, food consumption exhibited non-linear dependence on both body mass and temperature, such that food consumption was greatest in the heaviest animals at the coldest temperatures. Meadow jumping mice exhibited a strong circadian rhythm of nightly activity that was disrupted during the hibernation interval. We quantified the length and timing of torpor bouts and arousals obtained from an uninterrupted recording of a hibernating female. Over a 90.6 day hibernation interval, torpor bouts ranged from 2.1 to 12.8 days (mean 7.7 days), and arousal length was relatively constant with a mean length of 9.6 hours. We conclude that it is possible to study hibernation phenotypes using captive-bred meadow jumping mice in a laboratory setting.

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A Small-Scale Survey of Hantavirus in Mammals From Indiana

Cited by 5 publications

References 19 publications

Genetic Analysis of the Diversity and Origin of Hantaviruses in Peromyscus leucopus Mice in North America

Genetic Analysis of the Diversity and Origin of Hantaviruses in Peromyscus leucopus Mice in North America

Breeding and hibernation of captive meadow jumping mice (Zapus hudsonius)

Breeding and hibernation of captive meadow jumping mice (Zapus hudsonius)

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