The proposed Holistic Ecosystem for clinical Protocols and Trials Management (clinicalNET) project aims to establish a human and technical network of healthcare researchers, business partners, and stakeholders. The consortium will include specialists from various fields, including healthcare management, medicine, computer engineering, marketing, publishing, and public relations. The project will design and implement a semantically enabled information system for representing data and knowledge gathered during clinical trials. The clinicalNET project will define specifications for healthcare management services and knowledge engineering techniques, creating an intelligent collaborative web tool for information production and provision in healthcare. It will follow EU health policies and promote participation from leading researchers, stakeholders, and organizations. The clinicalNET will provide a health holistic ecosystem approach with open standards, trusted networks, and co-creator networks.