Wireless Sensor Networks (WSNs) have considerable awareness owing to their extensive scope of applications, to name a few being, natural disaster prohibition, health care monitoring video surveillance and so on. Moreover, the energy consumed during communication is a substantial quantity of energy loss and the routing protocol is the most suitable means to address this issue by fine-tuning weights to conserve the energy. Therefore the main issue experienced by WSN is the routing and data transmission and hence distinct points of reference need to be addressed when designing the routing protocol for real time healthcare monitoring. Motivated by these issues, in this work a method called, Probabilistic Generative Deep Belief and Differential Game Lotka Volterra (PGDB-DGLV) based data transmission in WSN for real-time health care monitoring is proposed. The PGDB-DGLV method is split into two sections, namely, optimal route discovery and robust data transmission. To measure route stability Balanced Centrality and Probabilistic Generative Deep Belief Network algorithm is designed. In the proposed model, a fine-tuned adjacency matrix employing the Stable Balanced Centrality function is defined to determine the next hop based on certain parameters like, hop count, residual energy and link quality. These parameters are salient assessments in adjacent node selections with which routing can be performed. Also, the initialization of the adjacency matrix and its corresponding fine-tuning is performed via the Probabilistic Generative Deep Belief Network. Second, to minimize the transmission speed and therefore reduce packet loss significantly, two kinds of game models, i.e., cooperative and cooperative models are constructed. Finally, the Lotka Volterra function is applied to ensure robust data transmission. At last, the performance of the proposed PGDB-DGLV method is evaluated using different evaluation metrics they are energy consumption, throughput transmission speed and packet loss rate. Finally, the evaluated results are compared with the prevailing data transmission methods. Among these methods, the proposed PGDB-DGLV method has achieved a better transmission speed with minimum energy consumption and maximum throughput considerably.