A smart magnetic nanoplatform for synergistic anticancer therapy: manoeuvring mussel-inspired functional magnetic nanoparticles for pH responsive anticancer drug delivery and hyperthermia

Abstract

We report the versatile design of a smart nanoplatform for thermo-chemotherapy treatment of cancer. For the first time in the literature, our design takes advantage of the outstanding properties of mussel-inspired multiple catecholic groups - presenting a unique copolymer poly(2-hydroxyethyl methacrylate-co-dopamine methacrylamide) p(HEMA-co-DMA) to surface functionalize the superparamagnetic iron oxide nanoparticles as well as to conjugate borate containing anticancer drug bortezomib (BTZ) in a pH-dependent manner for the synergistic anticancer treatment. The unique multiple anchoring groups can be used to substantially improve the affinity of the ligands to the surfaces of the nanoparticles to form ultrastable iron oxide nanoparticles with control over their hydrodynamic diameter and interfacial chemistry. Thus the BTZ-incorporated-bio-inspired-smart magnetic nanoplatform will act as a hyperthermic agent that delivers heat when an alternating magnetic field is applied while the BTZ-bound catechol moieties act as chemotherapeutic agents in a cancer environment by providing pH-dependent drug release for the synergistic thermo-chemotherapy application. The anticancer efficacy of these bio-inspired multifunctional smart magnetic nanoparticles was tested both in vitro and in vivo and found that these unique magnetic nanoplatforms can be established to endow for the next generation of nanomedicine for efficient and safe cancer therapy.

pH/NIR Light-Controlled Multidrug Release via a Mussel-Inspired Nanocomposite Hydrogel for Chemo-Photothermal Cancer Therapy

“…Then, the DP were dispersed in a deionized water/DMSO mixture (V/V = 10:1) and predetermined amounts of BTZ were added into the DP dispersion to start complexation between the catechol functionalities and the boronic acid active site of BTZ. It should be mentioned that the possibility of complexation between BTZ and catechol groups has been deeply studied in our previous works 17 27 . The resulting BTZ-loaded nanoparticles still kept the properties of DP nanoparticles, including strong photothermal conversion efficiency and excellent dispersibility in water.…”

Functionalized Non-vascular Nitinol Stent via Electropolymerized Polydopamine Thin Film Coating Loaded with Bortezomib Adjunct to Hyperthermia Therapy

“…The pH of the solution was increased to 9.0 to ensure the binding between catechol moiety and the boronic acid drug. It should be mentioned that the possibility of complexation between BTZ and catechol groups has been deeply studied in our previous works 14 , 27 , 28 .…”

Skin Cancer and Its Treatment: Novel Treatment Approaches with Emphasis on Nanotechnology

“…The magnetic field is created using strong permanent magnets, usually of the neodymium kind. In order to localize the nanoparticles in the target tissue, one must focus the magnetic field on a specific area to which the IONP (with the incorporated drug) are drawn [103,104]. The power and location of the magnetic field are adaptable, which means that we may control the nanoparticle accumulation, which lessens the unwanted cytotoxic effects on healthy tissues [105].…”