A Smart Metal–Organic Framework Nanomaterial for Lung Targeting

Simón-Yarza, Teresa; Giménez‐Marqués, Mónica; Mrimi, Rhizlaine; Mielcarek, Angelika; Gref, Ruxandra; Horcajada, Patricia; Serre, Christian; Couvreur, Patrick

doi:10.1002/anie.201707346

Cited by 125 publications

(85 citation statements)

References 29 publications

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“…In addition, PEG coating also led to a variation in the surface charge, from ζ‐potential values of −29 mV for MIL‐100(Fe), to the more neutral values of −24 and −23 mV for PEG 2kDa ‐ and PEG 5kDa ‐coated NPs, respectively. It is worth mentioning that dry PEG‐coated NPs can be easily redispersed in water maintaining the above mentioned average size, contrary to the irreversible aggregation observed for the bare MIL‐100(Fe) NP (from 129 to 235 nm) which is accompanied with a significant increase of the polydispersity in the sample (polydispersity index (PdI) increasing from <0.2 to 0.5) . This is of a great importance in view of clinical use of MOF nanocarriers.…”

Section: Resultsmentioning

confidence: 93%

GraftFast Surface Engineering to Improve MOF Nanoparticles Furtiveness

Giménez‐Marqués

Bellido

Berthelot

et al. 2018

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Controlling the outer surface of nanometric metal-organic frameworks (nanoMOFs) and further understanding the in vivo effect of the coated material are crucial for the convenient biomedical applications of MOFs. However, in most studies, the surface modification protocol is often associated with significant toxicity and/or lack of selectivity. As an alternative, how the highly selective and general grafting GraftFast method leads, through a green and simple process, to the successful attachment of multifunctional biopolymers (polyethylene glycol (PEG) and hyaluronic acid) on the external surface of nanoMOFs is reported. In particular, effectively PEGylated iron trimesate MIL-100(Fe) nanoparticles (NPs) exhibit suitable grafting stability and superior chemical and colloidal stability in different biofluids, while conserving full porosity and allowing the adsorption of bioactive molecules (cosmetic and antitumor agents). Furthermore, the nature of the MOF-PEG interaction is deeply investigated using high-resolution soft X-ray spectroscopy. Finally, a cell penetration study using the radio-labeled antitumor agent gemcitabine monophosphate ( H-GMP)-loaded MIL-100(Fe)@PEG NPs shows reduced macrophage phagocytosis, confirming a significant in vitro PEG furtiveness.

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Section: Resultsmentioning

confidence: 93%

GraftFast Surface Engineering to Improve MOF Nanoparticles Furtiveness

Giménez‐Marqués

Bellido

Berthelot

et al. 2018

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“…This potentially allows the nanoMOF formulations to be administered intravenously. Since the nanoMOF were shown to spontaneously target the lung, the treatment of S. aureus pneumonia could be one of the possible application of this system.…”

Section: Resultsmentioning

confidence: 99%

Compartmentalized Encapsulation of Two Antibiotics in Porous Nanoparticles: an Efficient Strategy to Treat Intracellular Infections

Semiramoth

Hall

et al. 2019

Part & Part Syst Charact

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Combinatorial drug therapies emerge among the most promising strategies to treat complex pathologies such as cancer and severe infections. Biocompatible nanoparticles of mesoporous iron carboxylate metal–organic framework (nanoMOFs) are used here to address the challenging aspects related to the coincorporation of two antibiotics. Amoxicillin and potassium clavulanate, a typical example of drugs used in tandem, are efficiently coincorporated with payloads up to 36 wt%. Due to the occurrence of two distinct pore sizes/apertures within the MOF architecture, each drug is able to infiltrate the porous framework and localize within separate compartments. Molecular simulations predict drug loadings and locations consistent with experimental findings. Drug loaded nanoMOFs that are internalized by Staphylococcus aureus infected macrophages are able to colocalize with the pathogen, which in turn leads to an alleviation of bacterial infection. The data also reveal potential antibacterial properties of nanoMOFs alone as well as their ability to deliver a high payload of drugs to fight intracellular bacteria. These results pave the way toward the design of engineered “all‐in‐one” nanocarriers in which both the loaded drugs and their carrier play a role in fighting intracellular infections.

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“…[1][2][3][4][5][6][7][8] MOFs which are assembled by metal ions/ clusters and organic ligands possess diversified composition, tailorable structure, large surface area, and uniform cavity. [21][22][23][24] Similar to the size-dependent properties which are wellknown for nanomaterials, reducing size of MOF crystals may bring enlarged specific surface area and increased density of active sites for MOFs, leading to improved performance. [9][10][11][12][13][14][15][16][17][18][19][20] Great efforts have been also devoted to preparing nanoscale MOF crystals with controllable size and morphology, in order to achieve enhanced performance in certain applications.…”

Section: Introductionmentioning

confidence: 99%

Structural Engineering of Low‐Dimensional Metal–Organic Frameworks: Synthesis, Properties, and Applications

et al. 2019

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Low‐dimensional metal–organic frameworks (LD MOFs) have attracted increasing attention in recent years, which successfully combine the unique properties of MOFs, e.g., large surface area, tailorable structure, and uniform cavity, with the distinctive physical and chemical properties of LD nanomaterials, e.g., high aspect ratio, abundant accessible active sites, and flexibility. Significant progress has been made in the morphological and structural regulation of LD MOFs in recent years. It is still of great significance to further explore the synthetic principles and dimensional‐dependent properties of LD MOFs. In this review, recent progress in the synthesis of LD MOF‐based materials and their applications are summarized, with an emphasis on the distinctive advantages of LD MOFs over their bulk counterparties. First, the unique physical and chemical properties of LD MOF‐based materials are briefly introduced. Synthetic strategies of various LD MOFs, including 1D MOFs, 2D MOFs, and LD MOF‐based composites, as well as their derivatives, are then summarized. Furthermore, the potential applications of LD MOF‐based materials in catalysis, energy storage, gas adsorption and separation, and sensing are introduced. Finally, challenges and opportunities of this fascinating research field are proposed.

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A Smart Metal–Organic Framework Nanomaterial for Lung Targeting

Cited by 125 publications

References 29 publications

GraftFast Surface Engineering to Improve MOF Nanoparticles Furtiveness

GraftFast Surface Engineering to Improve MOF Nanoparticles Furtiveness

Compartmentalized Encapsulation of Two Antibiotics in Porous Nanoparticles: an Efficient Strategy to Treat Intracellular Infections

Structural Engineering of Low‐Dimensional Metal–Organic Frameworks: Synthesis, Properties, and Applications

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