A smartphone-based biomedical sensory system

Abstract

Disease diagnostics, food safety monitoring and environmental quality monitoring are the key means to safeguard human health.

Electrochemiluminescence Mechanisms Investigated with Smartphone‐Based Sensor Data Modeling, Parameter Estimation and Sensitivity Analysis

“…This study used intensity data from measurements carried out with the smartphone-based ECL sensor for estimating the mechanistic model parameters. The ECL data were determined using the chronoamperometric technique where a square waveform potential was applied to the carbon working electrode with 50 μL of Ru (bpy) 3 2 + /TPrA sample solution. The potential of 1.2 V vs. Ag/Ag + produced ECL intensity from the triggering of the reactions of the chemical species in the Ru(bpy) 3 2 + /TPrA system.…”

“…The ECL data were determined using the chronoamperometric technique where a square waveform potential was applied to the carbon working electrode with 50 μL of Ru (bpy) 3 2 + /TPrA sample solution. The potential of 1.2 V vs. Ag/Ag + produced ECL intensity from the triggering of the reactions of the chemical species in the Ru(bpy) 3 2 + /TPrA system. Details of the chronoamperometric technique are presented elsewhere.…”

“…The electrochemiluminescence and its related mechanism are being extensively investigated due to its important application as a platform of light-emitting sensors and an analytical detection technique. [11,15,26,27] This study does not intend to deepen theoretical studies of the ECL mechanism of the Ru(bpy) 3 2 + /TPrA system, but rather to illustrate that the parameter estimation procedure of a complex system can be a straightforward task. Thus, this study used the reaction mechanisms originally proposed by Miao et al, [8] which are described in Eqs.…”

“…Optimizing the ECL performance (closely related to enhancement of the signal intensity) of smartphone-based sensors can be achieved by developing systematic methodologies to optimize the kinetic performance of existing luminophores and coreactants and also to design new ones. Therefore, it is necessary to study the kinetics of the Ru(bpy) 3 2 + /TPrA system occurring in a smartphone-based sensor to improve their ECL performance.…”

“…For this, a unified framework is used, which combines a mechanistic model with a genetic algorithm and utilizes experimental measurements from a low-cost smartphone-based ECL sensor. Secondly, through a sensitivity analysis (SA), a deep understanding of the ECL mechanism of the Ru (bpy) 3 2 + /TPrA system is obtained by examining the influence of the parameters on the model outputs (the transient profiles of the concentrations of all the species). The fractional factorial design is selected to perform the SA because it is a multivariate approach that can show global sensitivities of individual parameters.…”