A smartphone-based quantitative detection platform of mycotoxins based on multiple-color upconversion nanoparticles

Yang, Minye; Zhang, Ying; Cui, Meihui; Tian, Yu; Zhang, Shufang; Peng, Kang; Xu, Hongshuang; Liao, Zhenyu; Wang, Hanjie; Chang, Jin

doi:10.1039/c8nr04138e

Cited by 58 publications

(28 citation statements)

References 35 publications

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“…According to our previously published articles, carboxyl modified up-conversion particles (red, green, and blue) were prepared . Up-conversion particles (red, green, and blue) were dispersed with 200 μL of water.…”

Section: Methodsmentioning

confidence: 99%

Intelligent Detection Platform for Simultaneous Detection of Multiple MiRNAs Based on Smartphone

Tian¹,

Zhang²,

Wang³

et al. 2019

ACS Sens.

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As a marker of malignant tumors, miRNA is closely related to the occurrence and metastasis of tumors. How to achieve rapid and sensitive real-time detection is important for clinical prevention and treatment of cancer. In this study, an intelligent detection platform based on smartphone image processing technology made point-of-care testing a reality. This new smart approach could detect multiple targets simultaneously and sensitively. Hydrogel microparticles of different coding modes (shapes, numbers) were prepared by flow lithography to detect different miRNAs. After sandwich immunoassays, different shapes of hydrogels showed different fluorescence intensities depending on their targets. Images were captured by a smartphone and then analyzed by image recognition processing software installed on the smartphone. The concentration of miRNA was obtained within 10 s. The entire reaction process did not exceed 2 h. This intelligent and portable detection platform for miRNAs was reliable and the limit of detection reached the femtomole level. This work provided a demonstration of intelligent, portable, real-time detection of tumor markers.

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Section: Methodsmentioning

confidence: 99%

Intelligent Detection Platform for Simultaneous Detection of Multiple MiRNAs Based on Smartphone

Tian¹,

Zhang²,

Wang³

et al. 2019

ACS Sens.

Self Cite

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“…With such advanced technology, multiplex fluorescence imaging biosensors can be developed in a portable, cost‐effective manner. For example, a quantitative detection platform of mycotoxins was developed by integrating multicolored UCNPs barcode technology with portable fluorescence image processing device (Yang et al., 2018). The multicolored UCNPs were synthesized to label AFB1, OTA, and ZEN antibodies, respectively.…”

Section: Smartphone Integration Toward Point‐of‐care Testmentioning

confidence: 99%

Multiplex optical bioassays for food safety analysis: Toward on‐site detection

Guan

Jin

et al. 2022

Comp Rev Food Sci Food Safe

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Food safety analysis plays a significant role in controlling food contamination and supervision. In recent years, multiplex optical bioassays (MOBAs) have been widely applied to analyze multiple hazards due to their efficiency and low cost. However, due to the challenges such as multiplexing capacity, poor sensitivity, and bulky instrumentation, the further application of traditional MOBAs in food screening has been limited. In this review, effective strategies regarding food safety MOBAs are summarized, such as spatial‐resolution modes performed in multi‐T lines/dots strips or arrays of strip/microplate/microfluidic chip/SPR chip and signal‐resolution modes employing distinguishable colorimetric/luminescence/fluorescence/surface plasma resonance/surface‐enhanced Raman spectrum as signal tags. Following this, new trends on how to design engineered sensor architecture and exploit distinguishable signal reporters, how to improve both multiplexing capacity and sensitivity, and how to integrate these formats into smartphones so as to be mobile are summarized systematically. Typically, in the case of enhancing multiplexing capacity and detection throughput, microfluidic array chips with multichannel architecture would be a favorable approach to overcome the spatial and physical limitations of immunochromatographic assay (ICA) test strips. Moreover, noble metal nanoparticles and single‐excitation, multiple‐emission luminescence nanomaterials hold great potential in developing ultrasensitive MOBAs. Finally, the exploitation of innovative multiplexing strategy hybridized with powerful and widely available smartphones opens new perspectives to MOBAs. In future, the MOBAs should be more sensitive, have higher multiplexing capacity, and easier instrumentation.

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“…In the proposed work, the smartphone is used as a detector to determine the fluorescent nanoparticle's intensity level (29). The minimum required configuration for a smartphone as a detector is above the Jellybean android version and the camera must be 8 megapixels (MP) and above.…”

Section: Smartphonementioning

confidence: 99%

Fluorescence Nano Particle Detection in a Liquid Sample Using the Smartphone for Biomedical Application

2021

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In the present work, a Smartphone-based Fluorescence Nanoparticle Detector (SPF-NPD) was developed. This method is intended for use in the identification of biological agents in biomedical applications. Here, an android application-based algorithm was developed to analyze the fluorescent nanoparticle intensity level in a target sample. The setup consists of an LED light source, an Eppendorf tube holder, and a smartphone to acquire the fluorescent intensity level in the sample to enable the detection of pathogens within few seconds. High-resolution cameras available on recent smartphones have made live detection more accurate and convenient for healthcare applications. The concept of fluorescent nanoparticle detection with a smartphone has led to a portable device and having potential application in healthcare. In this proposed method the intensity level is analyzed with 5 pixels algorithm, the center pixel followed by four immediate neighbours' pixels which can analyze with minimal sample quantity. Also, the robustness of the developed algorithm was verified with various megapixel camera ranges from 8 MP to 20 MP.

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A smartphone-based quantitative detection platform of mycotoxins based on multiple-color upconversion nanoparticles

Cited by 58 publications

References 35 publications

Intelligent Detection Platform for Simultaneous Detection of Multiple MiRNAs Based on Smartphone

Intelligent Detection Platform for Simultaneous Detection of Multiple MiRNAs Based on Smartphone

Multiplex optical bioassays for food safety analysis: Toward on‐site detection

Fluorescence Nano Particle Detection in a Liquid Sample Using the Smartphone for Biomedical Application

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