A smartphone-integrated low-cost, reagent-free, non-destructive dried blood spot-based paper sensor for hematocrit measurement

Abstract

Blood Hematocrit(Hct) level provides vital information about a person's health. Traditional Hct measurement equipment relies heavily on infrastructure and skilled manpower, limiting their broad implementation in resource-limited contexts. Therefore, we...

On paper characterisation of droplet and evaporation study using impedance spectroscopy

“…21,22 Paper is used as a microfluidic substrate for the identification of various biomolecules and the examination of liquids. 23–27 In order to restrict the amount of fluids that are dispersed on the paper substrate, hydrophobically patterned paper is utilised in the process of conducting targeted chemical analysis. 28–30 Furthermore, the amount of sample needed for this analysis is smaller in comparison to conventional chemical analysis.…”

Targeted and untargeted metabolomics and lipidomics in dried blood microsampling: Recent applications and perspectives

“…With a high HCT, the blood spot will be smaller, more intense in colour and more homogenous. 10 , 11 Punching disks of the same size for blood spots with varying HCT levels results in different volumes, leading to significant measurement and quantification errors. 11 On a traditional DBS card, the spot is punched to remove it from the card.…”

“… 10 , 11 Punching disks of the same size for blood spots with varying HCT levels results in different volumes, leading to significant measurement and quantification errors. 11 On a traditional DBS card, the spot is punched to remove it from the card. Multiple punches can be made in one DBS spot.…”

“…Instead of creating new collection devices to overcome the haematocrit effect, it is also possible to develop tools to measure the HCT of the blood spot. It can be done optically, with a smartphone app, 11 reflectance spectroscopy, 24 near‐infrared or ultraviolet‐visible spectroscopy 25 , 26 , 27 or simply with a scanner and image analysis. 28 …”