Exhaled breath‐based disease diagnosis is an ancient technique, and the application of this technique is rapidly developing for disease quick testing, such as viral infection, asthma, chronic kidney disease, and so on. Among the diagnostic tools, an exhaled breath‐based test has demonstrated the merits of being non‐invasive, convenient, quick, and comfortable. In this review, the exhaled breath diagnosis via the gaseous part of the breath is the major focus. First, the summary of state‐of‐art studies based on exhaled gas detection is described. Second, typical disease‐related exhaled gas and their measurements are described. Finally, the various structure of field effect transistor (FET)‐type sensors for gas‐based disease detection is discussed in detail. This review may inspire new research ideas and directions for applying FET‐type sensors to quick disease detection via the gaseous route.