2023
DOI: 10.1080/10985549.2023.2256640
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A SNAI2/CTCF Interaction is Required for NOTCH1 Expression in Rhabdomyosarcoma

Prethish Sreenivas,
Long Wang,
Meng Wang
et al.

Abstract: Rhabdomyosarcoma (RMS) is a pediatric malignancy of the muscle with characteristics of cells blocked in differentiation. NOTCH1 is an oncogene that promotes self-renewal and blocks differentiation in the fusion negative-RMS sub-type. However, how NOTCH1 expression is transcriptionally maintained in tumors is unknown. Analyses of SNAI2 and CTCF chromatin binding and HiC analyses revealed a conserved SNAI2/CTCF overlapping peak downstream of the NOTCH1 … Show more

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