A snapshot of lipid levels in the Republic of Ireland in 2017

Agar, Ruth; Markham, C.; Prendergast, Meabh; Canning, Rebecca; Maher, Edana; Finn, Caroline; Sammon, Nuala; Fall, Sarah; Fallon, Noeleen; Hanrahan, Evonne; King, Lisa Sniderman; Maher, Vincent

doi:10.1007/s11845-018-1820-3

Cited by 5 publications

(5 citation statements)

References 32 publications

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“…Multiple subjects had TG values less than 45 mgÁdL À1 on at least 1 day, resulting in the inability to calculate LDL-C. Additionally, one subject exceeded 100 mgÁdL À1 for HDL-C on days 1 and 11. While this lipid cassette may be less valid compared with the gold standard CLIA-certified human diagnostic laboratory, 19 it has been used previously in field research, [20][21][22] with a coefficient of variation of less than 5% and intraclass correlation coefficients more than 0.8. 23 To measure hemoglobin A1c (HbA1c) on days 1 and 11, 1 mL of whole blood was transferred into a DCA HbA1c reagent kit and loaded into a DCA Vantage Analyzer (Siemens Healthineers, Malvern, PA).…”

Section: Blood Analysismentioning

confidence: 99%

Alterations in Metabolic and Cardiovascular Risk Factors During Critical Training in Wildland Firefighters

Gurney¹,

Christison

Williamson-Reisdorph³

et al. 2021

Journal of Occupational &Amp; Environmental Medicine

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Objective:To identify physiologic stressors related to cardiovascular disease via changes in metabolic, inflammatory, and oxidative stress biomarkers during 2 weeks of preseason training in wildland firefighters (WLFFs).Methods:Participants were recruited from a local hotshot crew and monitored during preseason training. Fitness was assessed via the Bureau of Land Management fitness challenge. Venipuncture blood was collected on days 1, 4, 8, and 11 and analyzed for changes in a lipid and glucose panel, C-reactive protein, and oxidative stress markers 8-isoprostane (8ISO), 3-nitrotyrosine (3NT), lipid hydroperoxides (LOOH), and protein carbonyls.Results:The high physical demands of training resulted in significant (P < 0.05) reductions in total cholesterol, glucose, and hemoglobin A1c. A main effect for time was observed in 8ISO, 3NT, and LOOH.Conclusions:Alterations in metabolic and oxidative stress markers suggest an acute, high-intensity physical stress during WLFF preseason training.

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Section: Blood Analysismentioning

confidence: 99%

Alterations in Metabolic and Cardiovascular Risk Factors During Critical Training in Wildland Firefighters

Gurney¹,

Christison

Williamson-Reisdorph³

et al. 2021

Journal of Occupational &Amp; Environmental Medicine

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“…Studies suggest a decline in cholesterol levels in Ireland since the 1980s [49][50][51]. A recent study identified one possible FH case among 259 of the public screened [49].…”

Section: Irelandmentioning

confidence: 99%

“…Studies suggest a decline in cholesterol levels in Ireland since the 1980s [49][50][51]. A recent study identified one possible FH case among 259 of the public screened [49]. A national FH database has been initiated, supported by industry, which also funds lipid nurses for FH screening.…”

Section: Irelandmentioning

confidence: 99%

Overview of the current status of familial hypercholesterolaemia care in over 60 countries - The EAS Familial Hypercholesterolaemia Studies Collaboration (FHSC)

et al. 2018

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The EAS FHSC is an international initiative involving a network of investigators interested in FH from around 70 countries.• Information on FH prevalence is lacking in most countries; where available, data tend to align with contemporary estimates.• FH diagnosis and management varies widely across countries, with overall suboptimal identification and under-treatment.• In most countries diagnosis primarily relies on DLCN criteria, and less frequently on Simon Broom or MEDPED.• Therapy for FH is not universally reimbursed, and criteria vary across countries. Access to PCSK9i and apheresis is limited.

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“…The extent of lipid problems in Ireland is significant, and lipid management [4,6] and lipid services are inadequate [15,16]. The significance of untreated lipid disorders on population health cannot be overestimated [17,18], and early interventions could have far-reaching consequences on Irish lives and health care resource utilisation.…”

Section: Discussionmentioning

confidence: 99%

“…2) was also produced to help guide interpretation when needed. A number of hyperlink materials were also developed to help familiarise practitioners with information that would enhance their understanding of the basis for intervention and need for further screening as deemed necessary [10][11][12][13][14][15].…”

Section: Methodsmentioning

confidence: 99%

Abbreviated lipid guidelines for clinical practice

et al. 2023

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Background Lipid disorders are now considered causal for atherosclerotic cardiovascular disease (ASCVD) which remains one of the most important contributors to morbidity and mortality in the developed world. Identification and early treatment of lipid disarrays remains the cornerstone of good clinical practice to prevent, halt and even reverse ASCVD. Guidelines for lipid management are imperative to help promote good clinical practice. Given the detail involved in comprehensive guidelines and the multiple areas of knowledge required by clinical practitioners, abbreviated, easy to understand, practical versions of guidelines are required to ensure dissemination of the most important information. The recent ESC lipid guidelines 2019 and the ESC guidelines on CVD prevention in clinical practice 2021 (1,2), provide an excellent detailed summary of all the latest evidence supporting lipid interventions that reduce ASCVD. Method We therefore developed a single-page document with hyperlinks to help practitioners gain easy access to practical information on lipid management. It has been developed for future electronic use in clinical practice. Conclusion It is presented here in a tabular format together with printable versions of the associated hyperlinks that provide the additional information required in decision making. It is hoped to audit the impact of this approach to help guide future ways of disseminating the latest clinical guideline updates.

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A snapshot of lipid levels in the Republic of Ireland in 2017

Abstract: This pilot study reveals significant lipid abnormalities which require further larger more detailed lipid studies to assess the true burden of lipid abnormalities in Ireland. Cascade screening and genetic testing of relatives of those with severe lipid abnormalities should be considered.

Cited by 5 publications

References 32 publications

Alterations in Metabolic and Cardiovascular Risk Factors During Critical Training in Wildland Firefighters

Alterations in Metabolic and Cardiovascular Risk Factors During Critical Training in Wildland Firefighters

Overview of the current status of familial hypercholesterolaemia care in over 60 countries - The EAS Familial Hypercholesterolaemia Studies Collaboration (FHSC)

Abbreviated lipid guidelines for clinical practice

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