A soft elastomer alternative to polypropylene for pelvic organ prolapse repair: a preliminary study

Knight, Katrina; King, Gabrielle E.; Palcsey, Stacy; Abramowitch, Steven D.; Moalli, Pamela

doi:10.1007/s00192-021-04792-0

Cited by 8 publications

(12 citation statements)

References 24 publications

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“…40 The PDMS mesh showed a better tissue incorporation and less reduction in vaginal muscle contractility compared with polypropylene. 40 However, PDMS is a non-degradable heavyweight polymer, which means that the long-term biocompatibility of this mesh is still unknown. The study of degradable polyurethane loaded with antibiotics manufactured by fused deposition modelling (FDM) is another promising option.…”

Section: Current Practicementioning

confidence: 94%

“…44 3D-printed PDMS mesh was implanted in New Zealand rabbits for 12 weeks. 40 The PDMS mesh showed a better tissue incorporation and less reduction in vaginal muscle contractility compared with polypropylene. 40 However, PDMS is a nondegradable heavyweight polymer, which means that the long-term biocompatibility of this mesh is still unknown.…”

Section: A Possible Materials Solutionmentioning

confidence: 94%

“…Some recent works have indicated the potential of polymerbased mesh. Polymer materials include materials such as the soft elastomer polydimethyl siloxane (PDMS), 40 polyurethane (PU) loaded with the antibiotic levofloxacin, 41 ureidopyrimidinone polycarbonate (UPy-PC), 42 ascorbic acid incorporated into poly lactic acid (PLA), 43 and oestradiol incorporated into poly lactic acid (PLA). 44 3D-printed PDMS mesh was implanted in New Zealand rabbits for 12 weeks.…”

Section: A Possible Materials Solutionmentioning

confidence: 99%

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Design, mechanical and degradation requirements of biodegradable metal mesh for pelvic floor reconstruction

et al. 2022

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Section: Current Practicementioning

confidence: 94%

Section: A Possible Materials Solutionmentioning

confidence: 94%

Section: A Possible Materials Solutionmentioning

confidence: 99%

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Design, mechanical and degradation requirements of biodegradable metal mesh for pelvic floor reconstruction

et al. 2022

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“…Porous polymer (polypropylene) meshes, modeled after those used in hernia surgeries, have been rightfully scrutinized for the high rate of deleterious side effects when used in transvaginal surgery for pelvic organ prolapse. 53 Pore size and overall porosity are critical to patient outcomes, and current research has examined both tissue-derived mesh substitutes and novel mesh designsboth in material and in pore geometry-explicitly addressing the clinical problems that arose with the now-recalled polypropylene products. 30,31 An example is shown in Figure 4d, in which an elastomeric material is used to print an auxetic mesh structure-one that widens when elongated instead of narrowing.…”

Section: Pelvic Floor Disordersmentioning

confidence: 99%

“…30,31 An example is shown in Figure 4d, in which an elastomeric material is used to print an auxetic mesh structure-one that widens when elongated instead of narrowing. 53 Until new mesh designs, mesh materials, and surgical BiOMATEriALS SciEncE And EnGinEErinG TO AddrESS UnMET nEEdS in wOMEn'S hEALTh approaches are validated, elastomeric intravaginal (removable) pessaries remain an alternative to surgery. 54…”

Section: Pelvic Floor Disordersmentioning

confidence: 99%

Biomaterials science and engineering to address unmet needs in women’s health

Oyen

2022

MRS Bulletin

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Medical conditions that primarily or disproportionately affect women have historically been poorly studied. In contrast to the musculoskeletal and cardiovascular systems, there is no lengthy record of biomaterials research addressing women's health needs. In this article, the historical reasons for this discrepancy are examined. The anatomy of both the nonpregnant and pregnant reproductive tissues is reviewed, including the ovaries, uterus, and (fetal) placenta. Examples of biomaterials-related women's health research are described, including tissue engineering, organoids, and microphysiological systems. The future of the field is considered with dual focuses. First, there is a significant need for novel approaches to advance women's health through materials and biomaterials, particularly in complex biomimetic hydrogels. Second, there is an exciting opportunity to enlarge the community of biomaterials scientists and engineers working in women's health to encourage more contributions to its rapidly emerging product development pipeline.

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The use of animal models in preclinical investigations for the development of a surgical mesh for pelvic organ prolapse

Seifalian,

Digesu,

Khullar

2024

Int Urogynecol J

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Introduction and hypothesis Polypropylene (PP) mesh for the treatment of pelvic organ prolapse (POP) has raised substantial concerns over long-term complications, leading to its ban in multiple countries. In response, emerging materials are being explored as alternatives for prolapse surgery. Preclinical animal models have historically played a pivotal role in validating medical devices, prior to clinical trials. Successful translation of these materials necessitates the identification of suitable animal models that replicate the female human pelvis and its biomechanical properties. Preclinical in vivo testing assesses the safety of surgical mesh and treatment efficacy in preventing POP recurrence. Methods The research critically reviews animal models used for preclinical pelvic mesh testing over the last decade and proposes a promising model for future preclinical studies. Results Rats were the most common mammal used for toxicity and biocompatibility investigations through abdominal implantation. Although non-human primates serve as a gold standard for efficacy testing, ethical considerations limit their use owing to their close biological and cognitive resemblance to humans. Consequently, sheep were the most preferred large animal model owing to their reproductive system similarities and propensity for spontaneous POP following parity. Conclusion The study contributes valuable insights into the selection of appropriate animal models for preclinical pelvic mesh testing, offering guidance that is crucial for enhancing the safety and efficacy of novel surgical interventions in the treatment of POP.

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A soft elastomer alternative to polypropylene for pelvic organ prolapse repair: a preliminary study

Cited by 8 publications

References 24 publications

Design, mechanical and degradation requirements of biodegradable metal mesh for pelvic floor reconstruction

Design, mechanical and degradation requirements of biodegradable metal mesh for pelvic floor reconstruction

Biomaterials science and engineering to address unmet needs in women’s health

The use of animal models in preclinical investigations for the development of a surgical mesh for pelvic organ prolapse

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