A Software to Visualize, Edit, Model and Mesh Vascular Networks

Decroocq, Meghane; Lavoué, Guillaume; Ohta, Makoto; Frindel, Carole

doi:10.1109/embc48229.2022.9871365

Cited by 3 publications

(3 citation statements)

References 20 publications

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“…Fortunately, thanks to its design, the model could be easily extended to include conditions closer to in vivo thrombolysis. We could instead reconstruct 60 patient-specific geometries with collateral vessels and try to reproduce the complex flow conditions observed in AIS patients 59 . In doing so, we could hypothesize the effect of artery geometry, thrombus location, and drug injection patterns on lysis efficacy.…”

Section: Discussionmentioning

confidence: 99%

A simplified mesoscale 3D model for characterizing fibrinolysis under flow conditions

Petkantchin

Rousseau

Boudjeltia

et al. 2023

Preprint

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One of the routine clinical treatments to eliminate ischemic stroke thrombi is injecting a biochemical product into the patient’s bloodstream, which breaks down the thrombi’s fibrin fibers: intravenous or intravascular thrombolysis. Unfortunately, however, the successful outcome of this procedure is still more of an exception than the rule. Understanding why from clinical evidence is close to impossible, given that no existing tool can track the lysis at the thrombus scale and that time is limited due to the emergency. For that reason, we conductedin vitroflow-driven fibrinolysis experiments to study pure fibrin thrombi breakdown in controlled conditions and observed that the lysis front evolved non-linearly in time. To understand these results, we developed an analytical 1D lysis model in which the thrombus is considered a porous medium. The lytic cascade is reduced to a second-order reaction involving fibrin and a surrogate pro-fibrinolytic agent. The model was able to reproduce the observed lysis evolution under the assumptions of constant fluid velocity and lysis occurring only at the front. For adding complexity, such as clot heterogeneity or complex flow conditions, we propose a 3-dimensional mesoscopic numerical model of blood flow and fibrinolysis, which validates the analytical model’s results. Such a numerical model could help us better understand the spatial evolution of the thrombi breakdown, extract the most relevant physiological parameters to lysis efficiency, and possibly explain the failure of the clinical treatment. These findings suggest that even though real-world fibrinolysis is a complex biological process, a simplified model can recover the main features of lysis evolution.

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Section: Discussionmentioning

confidence: 99%

A simplified mesoscale 3D model for characterizing fibrinolysis under flow conditions

Petkantchin

Rousseau

Boudjeltia

et al. 2023

Preprint

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show abstract

“…These methods are able to handle any type of branching point and their local nature enables efficient parallel processing. [DFOL22] also proposes a method to generate hex meshes from a curve skeleton following a similar approach. The size and the form factor of the elements prescribed by a simulation context are already accounted for in the cross section that is extruded to generate the hexahedra along the branches.…”

Section: Introductionmentioning

confidence: 99%

“…However, they are limited to domains that are well captured by their curve skeleton. While very useful for example in the medical domain to generate volume meshes for structures like lungs or blood vessels [DFOL22], they handle a fairly narrow range of application domains. When the shape to mesh contains flattened areas, the quality of the results decreases rapidly, if a viable mesh can be obtained at all.…”

Section: Introductionmentioning

confidence: 99%

Meso‐Skeleton Guided Hexahedral Mesh Design

Viville,

Kraemer,

Bechmann

2023

Computer Graphics Forum

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We present a novel approach for the generation of hexahedral meshes in a volume domain given its meso‐skeleton. This compact representation of the topology and geometry, composed of both curve and surface parts, is used to produce a raw decomposition of the domain into hexahedral blocks. Analysis of the different local configurations of the skeleton leads to the construction of a set of connection surfaces that are used as a scaffold onto which the hexahedral blocks are assembled. These local configurations of the skeleton completely determine the singularities of the final mesh, and by following the skeleton, the geometry of the produced mesh naturally follows the geometry of the domain. Depending on the end user needs, the obtained mesh can be further adapted, refined or optimized, for example to better fit the boundary of the domain. Our algorithm does not involve the resolution of any global problem, most decisions are taken locally and it is thus highly suitable for parallel processing. This efficiency allows the user to stay in the loop for the correction or edition of the meso‐skeleton for which a first sketch can be given by an existing automatic extraction algorithm.

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A simplified mesoscale 3D model for characterizing fibrinolysis under flow conditions

Petkantchin,

Rousseau,

Eker

et al. 2023

Sci Rep

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One of the routine clinical treatments to eliminate ischemic stroke thrombi is injecting a biochemical product into the patient’s bloodstream, which breaks down the thrombi’s fibrin fibers: intravenous or intravascular thrombolysis. However, this procedure is not without risk for the patient; the worst circumstances can cause a brain hemorrhage or embolism that can be fatal. Improvement in patient management drastically reduced these risks, and patients who benefited from thrombolysis soon after the onset of the stroke have a significantly better 3-month prognosis, but treatment success is highly variable. The causes of this variability remain unclear, and it is likely that some fundamental aspects still require thorough investigations. For that reason, we conducted in vitro flow-driven fibrinolysis experiments to study pure fibrin thrombi breakdown in controlled conditions and observed that the lysis front evolved non-linearly in time. To understand these results, we developed an analytical 1D lysis model in which the thrombus is considered a porous medium. The lytic cascade is reduced to a second-order reaction involving fibrin and a surrogate pro-fibrinolytic agent. The model was able to reproduce the observed lysis evolution under the assumptions of constant fluid velocity and lysis occurring only at the front. For adding complexity, such as clot heterogeneity or complex flow conditions, we propose a 3-dimensional mesoscopic numerical model of blood flow and fibrinolysis, which validates the analytical model’s results. Such a numerical model could help us better understand the spatial evolution of the thrombi breakdown, extract the most relevant physiological parameters to lysis efficiency, and possibly explain the failure of the clinical treatment. These findings suggest that even though real-world fibrinolysis is a complex biological process, a simplified model can recover the main features of lysis evolution.

show abstract

A Software to Visualize, Edit, Model and Mesh Vascular Networks

Cited by 3 publications

References 20 publications

A simplified mesoscale 3D model for characterizing fibrinolysis under flow conditions

A simplified mesoscale 3D model for characterizing fibrinolysis under flow conditions

Meso‐Skeleton Guided Hexahedral Mesh Design

A simplified mesoscale 3D model for characterizing fibrinolysis under flow conditions

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