2022
DOI: 10.3390/antibiotics11050679
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A Soil-Isolated Streptomyces spororaveus Species Produces a High-Molecular-Weight Antibiotic AF1 against Fungi and Gram-Positive Bacteria

Abstract: The overuse of antibiotics has resulted in the emergence of antibiotic resistance, not only in bacteria but also in fungi. Streptomyces are known to produce numerous secondary metabolites including clinically useful antibiotics. In this study, we screened for antibiotic-producing actinobacteria from soils in Taipei and discovered a Streptomyces strain SC26 that displayed antimicrobial activities against Gram-positive bacteria and fungi, but the compounds are heat-labile. Upon UV mutagenesis, a late-sporulation… Show more

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“…About 2/3 of clinically useful antibiotics were produced by Streptomyces sp., including many important drugs, such as streptomycin, neomycin, kanamycin, rapamycin, chloramphenicol, vancomycin, etc. [43]. Therefore, the extracts of Streptomyces sp.…”
Section: Discussionmentioning
confidence: 99%
“…About 2/3 of clinically useful antibiotics were produced by Streptomyces sp., including many important drugs, such as streptomycin, neomycin, kanamycin, rapamycin, chloramphenicol, vancomycin, etc. [43]. Therefore, the extracts of Streptomyces sp.…”
Section: Discussionmentioning
confidence: 99%