A sole multi-analyte receptor responds with three distinct fluorescence signals: traffic signal like sensing of Al³⁺, Zn²⁺and F⁻

Abstract

A dialdehyde-based multi-analyte sensor renders distinctive emission spectra for Al(3+), Zn(2+) and F(-) ions. The ligand exhibited different types of interactions with these three different ions resulting in the enhancement of fluorescence intensity at three different wavelengths. All the sensing processes were studied in detail by absorption spectroscopy, emission spectroscopy and (1)H-NMR titration experiment. The ligand has the working ability in a wide pH range including the physiological pH. The ligand is non-toxic and amicable for sensing intracellular Al(3+) and Zn(2+) in live HeLa cells.

An OFF–ON–OFF type fluorescent probe based on a naphthalene derivative for Al3+ and F− ions and its biological application

“…The detection limit could also be calculated from the fluorescence titration experiment. The detection limit of sensor L towards Al 3+ was calculated as 4.08 × 10 −9 M, in the range 0.5–25 μM based on 3 σ blank /k, in which σ blank is the standard deviation of the blank solution, k is the slope of the calibration curve (Figure S1), which was much lower than most previously reported assays for Al 3+ detection . The combined relationship between L and Al 3+ in ethanol was calculated using the Benesi–Hildebrand equation, for which the association constant K a was evaluated as 5.748 × 10 3 M −1 (Fig.…”

“…Fluorescence probe L itself has no fluorescence emission but the addition of Al 3+ induced blue fluorescence emission. Both the phenomena of charge transfer from hydroxyl group to naphthalene moiety (ICT) and cis − trans interconversion around the C = N bond in L relies on the presence of Al 3+ , which is the trigger of the switch ON response in the fluorescence spectra following the CHEF mechanism . The addition of F − to the [L − Al 3+ ] complex constituted a reversible monitoring process as fluorescence was quenched due to the high stability of [AlF] 2+ .…”

A Vanillinyl‐Hydrazone Schiff Base: Recognition of Mg2+, Zn2+, Cd2+ and I− by Turn‐On Fluorescence Method

“…There is a upsurge to design chemosensor for the detection of toxic ions/molecules in environmental, biological and analytical samples . However, the design of a probe with multi‐ion sensing capability at ambient condition is a difficult task . Very small change like, structure, electronic property, chelate cavity size and steric effect and also to the ion size, ion charge, ionic potential, solvation dynamics about the ion etc.…”

Analytical methods for determination and sensing of fluoride in biotic and abiotic sources: a review

“…112,113 Consequently, there is a need to develop a substitute sensing method for the detection of an anion through sensing of a cation. Datta et al 133 utilized quinoline hydrazide residue for binding both the cation and anion. 123 The probe has been synthesised by covalently attaching 7-nitro-2,1,3- in fluorescence.…”