A Solid-State Approach to Enable Early Development Compounds: Selection and Animsal Bioavailability Studies of an Itraconazole Amorphous Solid Dispersion

Excipients for Amorphous Solid Dispersions

“…It has been reported that the ASD of griseofulvin prepared by coevaporation and of a new triazol antifungal drug candidate by SD using an enteric cellulosic ester HPMCP showed drastic increase in the dissolution rate compared to the pure drugs (Hasegawa et al 1985;Kai et al1996). Engers et al reported that the amorphous SDD of itraconazole with HPMCP displayed the best homogeneity (the narrowest T g width) and the highest physical stability among the different stabilizers tested (Engers et al 2010). …”

Simvastatin-nicotinamide co-crystal: design, preparation and preliminary characterization

“…X-ray powder diffraction is a specific technique to confirm whether the new solid state and the pharmaceutical co-crystal are prone to forming isostructural phases [23]. The intensity of the emissions from the co-crystal showed a decreasing tendency in intensity due to changes in crystal habits [24]. Consequently, a number of distinct co-crystal peaks were obtained as compared to the PM, thus indicating a different structure.…”

Anti-inflammatory and pharmacokinetics evaluation of PEGylated ibuprofen tablet formulation

“…The C max was higher in the formulated tablets than the reference drug and the PS, an indication that the PEGylated system could deliver the drug orally. The peak plasma concentration was reached 3 h after oral administration of the PEGylated ibuprofen tablets and sustained its effect for additional 2 h, before it declined at 24 h. The importance of this evaluation was to enable the pharmaceutical industries to determine the exert concentration of the drug in the system over a period of time and also to predict the frequency of dosage administration as evaluated by Engers et al (2010).…”