A solitary crateriform ulcer of the lower lip: A case report with review of literature

Abstract

Keratoacanthoma (KA) is a relatively common skin lesion. We report a case of KA-mimicking squamous cell carcinoma in a 40-year old smoker, who was also having speckeled leukoplakia on the buccal mucosa. The present case highlights the importance of histopathological diagnosis, as the treatment in latter case is aggressive, which is unnecessary if attempted with KA. Moreover, the present report provides an overview of such lesions, which could be encountered in clinical situations for which definitive diagnosis is of paramount importance before the starting of treatment plan.

A two-step technique to fabricate a glass fiber-reinforced composite interim removable partial denture: Case report

“…The other possible diff erentials such as WDSCC, actinic keratosis, verrucous carcinoma, verruca vulgaris, giant molluscum contagiosum and metastatic cancer were ruled out. [3] Discussion KA has been known to occur in all age groups, but majority of cases have been reported to occur over 40 years of age, with a male predilection, which is in accordance with the present case.…”

“…Clinically, natural history of KA include three stages; proliferative, mature and involutional or resolving. [3] Although, the natural course of KA is distinct from that of a WDSCC, it is of utmost importance to diff erentiate and arrive at a valid diagnosis.…”

“…Descriptively it is referred to as "volcano,'" as it presents with centrally depressed keratin-fi lled crater. [3] Histopathologically, it closely resembles well-diff erentiated squamous cell carcinoma (WDSCC) and the inclusion of clinically normal biopsy of KA is well-justifi ed as it is the overall pattern of tumour that is diagnostically more important than the impression of the individual cells. [1] Case Report A 35-year-old male reported with the chief complaint of a growth over the lower lip with duration of 1½ months.…”

“…However Freudenthal coined the term KA, later used by Rook and Whimster (1950) in their case series. [3] Though the precise etiology still remains unknown, certain etiological factors have been proposed like sun-light, chemical carcinogens, genetic factors, trauma, human papilloma virus and immunocompromised status. Recent research data suggests that about one-third of the cases bear chromosomal aberrations such as additions and deletions, etc.…”

Tumors with Pilosebaceous Differentiation: A Five Year Retrospective Study at BPKIHS

“…This lesion; which most commonly involves the face and hands, is a rapidly-growing cutaneous tumor with atypical histopathological manifestations that resembles the squamous cell carcinoma (SCC). It leaves an atrophic scar when resolves 23,24 .…”