A Solitary Fibrous Tumor of the Subglottic Larynx: Case Report and Literature Review

Park, Sung-Joon; Lee, Young Hen; Lee, Ki Yeol; Oh, Kyoung Ho; Kim, Younghye

doi:10.5152/balkanmedj.2016.151069

Cited by 12 publications

(6 citation statements)

References 8 publications

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“…About 70% of SFTs originate from thoracic structures, most often pleura (as was the case in the first-reported series described by Wagner in 1870) ( 1 ). SFTs have subsequently been described at almost every extrapleural anatomical site ( 2 , 3 , 4 ). The etiology of SFTs remains unknown, and no association has been demonstrated with environmental factors such as tobacco consumption or asbestos exposure ( 2 ).…”

Section: Solitary Fibrous Tumors Of Chest: Another Look With the Oncomentioning

confidence: 99%

Solitary Fibrous Tumors of Chest: Another Look with the Oncologic Perspective

Saynak

Veeramachaneni

Hubbs³

et al. 2017

Balkan Med J

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Solitary ﬁbrous tumors are mesenchymal lesions that arise at a variety of sites, most commonly the pleura. Most patients are asymptomatic at diagnosis, with lesions being detected incidentally. Nevertheless, some patients present due to symptoms from local tumor compression (eg. of the airways and pulmonary parenchyma). Furthermore, radiological methods are not always conclusive in making a diagnosis, and thus, pathological analysis is often required. In the past three decades, immunohistochemical techniques have provided a gold standard in solitary ﬁbrous tumor diagnosis. The signature marker of solitary ﬁbrous tumor is the presence of the NAB2-STAT6 fusion that can be reliably detected with a STAT6 antibody. While solitary ﬁbrous tumors are most often benign, they can be malignant in 10-20% of the cases. Unfortunately, histological parameters are not always predictive of benign vs malignant solitary ﬁbrous tumors. As solitary ﬁbrous tumors are generally regarded as relatively chemoresistant tumors; treatment is often limited to localized treatment modalities. The optimal treatment of solitary ﬁbrous tumors appears to be complete surgical resection for both primary and local recurrent disease. However, in cases of suboptimal resection, large disease burden, or advanced recurrence, a multidisciplinary approach may be preferable. Specifically, radiotherapy for inoperable local disease can provide palliation/shrinkage. Given their sometimes -unpredictable and often- protracted clinical course, long-term follow-up post-resection is recommended.

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Section: Solitary Fibrous Tumors Of Chest: Another Look With the Oncomentioning

confidence: 99%

Solitary Fibrous Tumors of Chest: Another Look with the Oncologic Perspective

Saynak

Veeramachaneni

Hubbs³

et al. 2017

Balkan Med J

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“…However, when a tumor is suspected, otolaryngologists should always perform a complete and systematic examination of the larynx to detect a subglottic lipoma, subglottic solitary fibrous tumor, or subglottic chondrosarcoma. 10,11 We searched MEDLINE using the keywords “laryngeal lipoma” and “subglottic area,” but no relevant literature was found.…”

Section: Discussionmentioning

confidence: 99%

Large lipoma in the subglottic larynx: a case report

Yun-xia¹,

Zhou²,

Wang³

2020

J Int Med Res

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Lipomas are rare benign tumors in the larynx. We encountered a 70-year-old man with a large lipoma in the subglottic area. His chief symptom was a 3-month history of progressive dyspnea. Transnasal flexible endoscopy showed a large mass on the posterior wall of the subglottic region. A computed tomography scan revealed a lesion occupying 75% to 80% of the subglottic airway. In this article, we discuss the imaging changes, clinical evaluation, and treatment of this patient’s lipoma.

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“…Peritoneal cavities, usually the retroperitoneum or pelvic soft tissue, are the primary site of origin in 30% of SFTs [8,9]. 20% occur in Case Reports in Medicine the head and neck, the meninges, or extracranial locations [10][11][12]. ese can include the sinonasal tract, oral cavity, and orbit [13][14][15].…”

Section: Discussionmentioning

confidence: 99%

Single Solitary Fibrous Tumor Brain Metastasis in a Patient with Simultaneous Adenocarcinoma of the Lung: Case Report and Review of the Literature

Kaya

Carlson

Thomas

et al. 2020

Case Reports in Medicine

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We present a unique case of a patient simultaneously diagnosed with solitary fibrous tumor (SFT) and unrelated adenocarcinoma of the lung, both proven with separate pathology. It was subsequently found that the SFT had metastasized to the brain by additional pathology, and not the predicted adenocarcinoma. SFTs are a rare mesenchymal neoplasm that accounts for less than 2% of all reported soft tissue tumors. SFTs most commonly arise in the thoracic cavity, but are frequently found in various locations throughout the body, and rarely metastasize to the brain. This case highlights that rare neoplasms, such as SFT, should not be ruled out as a potential cause of metastasis. Due to the rarity of this clinical situation, we also provide a review and discussion of previously reported SFT cases and the use of postoperative radiation therapy. The optimal treatment for individual patients remains unclear in this unique situation. Surgical resection followed by adjuvant Gamma Knife radiation therapy to the surgical bed appears to be a safe option for local treatment of SFT in select patients. Further studies are needed of this rare clinical situation in order to better understand and optimize future treatments for patients with SFT and metastasis to the brain.

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A Solitary Fibrous Tumor of the Subglottic Larynx: Case Report and Literature Review

Cited by 12 publications

References 8 publications

Solitary Fibrous Tumors of Chest: Another Look with the Oncologic Perspective

Solitary Fibrous Tumors of Chest: Another Look with the Oncologic Perspective

Large lipoma in the subglottic larynx: a case report

Single Solitary Fibrous Tumor Brain Metastasis in a Patient with Simultaneous Adenocarcinoma of the Lung: Case Report and Review of the Literature

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