A Southwest Nigerian tertiary hospital 5-year study of the pattern of liver disease admission

Adekanle, Olusegun; Ijarotimi, Oluwasegun; Obasi, Emmanuel; Anthony-Nwojo, Nnenna Grace; Ndububa, DA

doi:10.4103/njgh.njgh_7_20

Cited by 9 publications

(15 citation statements)

References 11 publications

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“…32 Adekanle et al (2019) similarly documented a mean age of 46.7 (SD=15.3) years, mean duration of admission of 33.4 (SD=26.5) days and a mortality of 47.6% in their retrospective study of patients with liver disease (including hepatocellular cancer and liver cirrhosis, acute hepatitis and metastatic liver disease among others), conducted between 2013 and 2017in a teaching hospital in Southwest Nigeria. 10 In our study, all the patients for whom data were available presented in the late stages of disease, hence time between presentation and demise was very short. This would have resulted in a reduction in healthcare costs from hospital admission and transportation for follow-up clinic visits and poorer health outcome.…”

Section: Medical Costs Of Lung Cancermentioning

confidence: 86%

Section: Discussionmentioning

confidence: 99%

“…Adekanle et al in their review of records of patients admitted with liver diseases into a tertiary hospital in Ile-Ife, Nigeria, from 2013 to 2017 found that hepatocellular carcinoma and liver cirrhosis accounted for 52.8% and 27.2% of all cases of liver disease admitted during the review period. 10 Cost-of-illness studies determine the burden of diseases to society in monetary terms. In addition, they provide an estimate of the amount that could potentially be saved if a disease were to be eradicated.…”

Section: Strengths and Limitations Of This Studymentioning

confidence: 99%

“…Adekanle et al in their review of records of patients admitted with liver diseases into a tertiary hospital in Ile–Ife, Nigeria, from 2013 to 2017 found that hepatocellular carcinoma and liver cirrhosis accounted for 52.8% and 27.2% of all cases of liver disease admitted during the review period. 10 …”

Section: Introductionmentioning

confidence: 99%

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Economic costs of terminal care for selected non-communicable diseases from a healthcare perspective: a review of mortality records from a tertiary hospital in Nigeria

et al. 2021

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IntroductionWHO revealed that morbidity and mortality from non-communicable diseases (NCDs) are on the increase and NCDs accounted for approximately 29% of all deaths in Nigeria in 2016. This study was conducted to estimate the economic cost of selected NCDs—lung cancer, liver cancer and liver cirrhosis. These diseases are known to be associated with key modifiable health risk behaviours (smoking and alcohol use), which are prevalent in Nigeria and often commence during the adolescent years.MethodsData were obtained between 2016 and 2017, from mortality records of patients managed for the selected diseases in the University College Hospital, a major referral centre in Nigeria. Information on costs of treatment, clinic visits, admission and transportation was obtained. Average costs of terminal in-patient care and transportation costs (in 2020 prices) were computed per patient. Costs were converted to the US dollar equivalent using the current official rate of US$1: ₦360.50.ResultsTwenty-two (out of 90 cases recorded) could be retrieved and all the patients had been diagnosed in the terminal stages of the disease. The average direct costs were ₦510 152.62 (US$1415.13) for an average of 49.2 days of terminal care for lung cancer; ₦308 950.27 (US$857.00) and ₦238 121.83 (US$660.53) for an average of 16.6 and 21.7 days of terminal care for patients managed for liver cancer and liver cirrhosis, respectively.ConclusionThe economic costs of each of the diseases were very high. Findings emphasise the need for aggressive efforts to promote primary prevention, improve early diagnosis and provide affordable treatment in view of the fact that the monthly minimum wage is less than US$85.00 and treatment costs are borne out-of-pocket by the generality of the population in Nigeria.

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Section: Medical Costs Of Lung Cancermentioning

confidence: 86%

Section: Discussionmentioning

confidence: 99%

Section: Strengths and Limitations Of This Studymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Economic costs of terminal care for selected non-communicable diseases from a healthcare perspective: a review of mortality records from a tertiary hospital in Nigeria

et al. 2021

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“…It is therefore plausible that patients seen at our centre had more advanced or severe disease since patients from secondary referral centres are transferred to higher level canters. Similar studies in West Africa also report high mortality for cirrhosis and HCC cases admitted to medical wards with a study in a tertiary referral centre in South-West Nigeria reporting a very high mortality rate at 82% [ 36 , 37 ].…”

Section: Discussionmentioning

confidence: 60%

Mortality burden due to liver cirrhosis and hepatocellular carcinoma in Ghana; prevalence of risk factors and predictors of poor in-hospital survival

et al. 2022

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Liver-related diseases, including liver cirrhosis and hepatocellular carcinoma (HCC), are significant causes of mortality globally. Specific causes and predictors of liver-related mortality in low resource settings require assessment to help inform clinical decision making and develop strategies for improved survival. The objectives of this study were to determine the proportion of liver-related deaths associated with liver cirrhosis, HCC, and their known risk factors, and secondly to determine predictors of in-hospital mortality among cirrhosis and HCC patients in Ghana. We first performed a cross-sectional review of death register entries from 11 referral hospitals in Ghana to determine the proportion of liver-related deaths and the proportion of risk factors associated with these deaths. Secondly, we conducted a retrospective cohort review of 172 in-patient liver cirrhosis and HCC cases admitted to a tertiary referral centre and determined predictors of in-hospital mortality using binary logistic regression and Kaplan-Meier survival analysis. In total, 8.8% of deaths in Ghanaian adults were due to liver-related causes. The proportion of liver-related deaths attributed to HBV infection was 48.8% (95% CI: 45.95–51.76), HCV infection was 7.0% (95% CI: 5.58–8.45), HBV-HCV co-infection 0.5% (95% CI: 0.1–0.9) and alcohol was 10.0% (95% CI: 8.30–11.67). Of 172 cases of HCC and liver cirrhosis, the in-patient mortality rate was 54.1%. Predictors of in-patient mortality in cirrhotic patients were increasing WBC (OR = 1.14 95% CI: 1.00–1.30) and the revised model for end-stage liver disease with sodium (MELD-Na) score (OR = 1.24 95% CI: 1.01–1.54). For HCC patients, female sex (OR = 3.74 95% CI: 1.09–12.81) and hepatic encephalopathy (grade 1) were associated with higher mortality (OR = 5.66 95% CI: 1.10–29.2). In conclusion, HBV is linked to a high proportion of HCC-related deaths in Ghana, with high in-hospital mortality rates that require targeted policies to improve survival.

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Potential deleterious effects of paracetamol dose regime used in Nigeria versus that of the United States of America

et al. 2022

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A Southwest Nigerian tertiary hospital 5-year study of the pattern of liver disease admission

Cited by 9 publications

References 11 publications

Economic costs of terminal care for selected non-communicable diseases from a healthcare perspective: a review of mortality records from a tertiary hospital in Nigeria

Economic costs of terminal care for selected non-communicable diseases from a healthcare perspective: a review of mortality records from a tertiary hospital in Nigeria

Mortality burden due to liver cirrhosis and hepatocellular carcinoma in Ghana; prevalence of risk factors and predictors of poor in-hospital survival

Potential deleterious effects of paracetamol dose regime used in Nigeria versus that of the United States of America

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