A Soy Bean Food Preparation for Feeding Infants With Milk Idiosyncrasy

Hill, Lewis Webb

doi:10.1001/jama.1929.02710130025008

Cited by 84 publications

(19 citation statements)

References 4 publications

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“…Only in 1929 a SPF was employed for feeding babies with CMA (8). Originally, fat-free soy flour was used as the source of protein, but non digestible carbohydrates, among which primarily stachyose and raffinose tended to produce loose, malodorous stools in infants fed these formulas.…”

Section: Introductionmentioning

confidence: 99%

Natural history of soy allergy and/or intolerance in children, and clinical use of soy‐protein formulas

Cantani

Lucenti

1997

Pediatric Allergy Immunology

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Atopic diseases of infants and children are common, debilitating, chronic and sometimes even life-threatening. Several well-conducted studies in high risk babies have demonstrated a significant reduction in the prevalence and severity of atopic diseases with dietary and environmental manipulations. The currently available cow's milk (CM) substitutes for infants are soy protein (SP) formulas (SPFs), hydrolyzed formulas (HF), and home-made meat-based formulas. Soybeans have been cultivated in Eastern countries for many centuries and were first used to feed US babies with CM allergy (CMA) in 1929. Since then, SPFs containing purified SP, a mixture of vegetable oils, and purified carbohydrate have been developed. From a nutritional point of view, SPFs are adequate, support normal growth, protein status, bone mineralization, are well accepted, and economical. SPFs are used for different conditions including CMA, lactose and galactose intolerance and in the management of severe gastroenteritis, and some studies show that feeding SPFs for the first six months of life significantly reduces the prevalence of atopic diseases in high risk babies. Although gastrointestinal symptoms and atopic dermatitis (AD) may occur in some SPF-fed children, anaphylaxis following the ingestion of soybean is extremely rare in children. However, in the past few years the antigenicity/allergenicity of SPFs has been over-emphasized in the medical literature. In this paper on the natural history of soy antigenicity/allergenicity we discuss all the pros and cons of SPFs, their composition and nutritional value, the basic immune definitions, chemistry and characterization of SPs. We then discuss the antigenicity and allergenicity of SPFs in animals, recent data on the use of SPFs and the incidence of soy allergy in children, clinical reactions to SPFs, and the clinical relevance of skin testing and IgE antibodies to soy, challenge test procedure, clinical indication of SPFs, and their relevance in the prevention of atopy. We have meta-analyzed 17 different studies and conclude that history-based SPF allergy incidence totals 27%, in skin prick tests (SPT) RAST-oral food challenge (OFC)/double-blind food challenge (DBFC)-based epidemiological studies attains 3%, and in challenge test studies 4%. We suggest that double-blind placebo-controlled food challenge (DBPCFC) studies in larger cohorts of babies may establish a more reliable prevalence of SPF allergy in different disorders associated with CMA.

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Section: Introductionmentioning

confidence: 99%

Natural history of soy allergy and/or intolerance in children, and clinical use of soy‐protein formulas

Cantani

Lucenti

1997

Pediatric Allergy Immunology

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“…Allergic reactions to soybean proteins have been a well established fact since Hill and Stuart [1] recom mended, for the first time, the substitution of soybean preparations for cow's milk in children with intoler ance to the latter. Following ingestion of various soyacontaining mixtures, sensitive individuals were likely to develop urticaria, angioedema, gastrointestinal symptoms, asthma and systemic anaphylaxis [2][3][4].…”

Section: Introductionmentioning

confidence: 99%

Identification of Soybean Proteins Responsible for Respiratory Allergies

González¹,

Zapatero

Caravaca³

et al. 1991

Int Arch Allergy Immunol

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Serum samples from 32 patients who suffered attacks during the asthma outbreaks of 1987 and 1988 in Cartagena, Spain, supposedly caused by soybean dust, were studied. At least 90% had specific IgE to shell components and only 13% showed specific IgE to shell-depleted soybean grains. A control group of 32 patients who also suffered asthma attacks but on different days from those of the outbreaks were negative. The shell’s most important allergen with an apparent molecular weight of 8 kDa was not present in shell-depleted grains. This allergen as well as other less important shell allergens may be different from the allergens already identified by using serum from patients suffering food allergy to soya.

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“…Consumption of soy and soy oil is common and for example soy-based infant formulas have been used since 1929 (Hill and Stuart, 1929). Soy and soy protein formula have been shown to cause allergies and other intolerant reactions and affect a number of adults and children.…”

Section: Assessmentmentioning

confidence: 99%

Opinion of the Scientific Panel on Dietetic Products, Nutrition and Allergies on a request from the Commission related to a notification from FEDIOL and IMACE on fully refined soybean oil and fat pursuant to Article 6, paragraph 11 of Directive 2000/13/EC

2007

EFSA Journal

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A Soy Bean Food Preparation for Feeding Infants With Milk Idiosyncrasy

Cited by 84 publications

References 4 publications

Natural history of soy allergy and/or intolerance in children, and clinical use of soy‐protein formulas

Natural history of soy allergy and/or intolerance in children, and clinical use of soy‐protein formulas

Identification of Soybean Proteins Responsible for Respiratory Allergies

Opinion of the Scientific Panel on Dietetic Products, Nutrition and Allergies on a request from the Commission related to a notification from FEDIOL and IMACE on fully refined soybean oil and fat pursuant to Article 6, paragraph 11 of Directive 2000/13/EC

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