A space network structure constructed by tetraneedlelike ZnO whiskers supporting boron nitride nanosheets to enhance comprehensive properties of poly(L-lacti acid) scaffolds

Abstract

In this study, the mechanical strength and modulus of poly(L-lacti acid) (PLLA) scaffolds were enhanced with the mechanical properties of boron nitride nanosheets (BNNSs) and tetraneedlelike ZnO whiskers (T-ZnOw). The adhesion and proliferation of cells were improved as well as osteogenic differentiation of stem cells was increased. Their dispersion statues in PLLA matrix were improved through a space network structure constructed by three-dimensional T-ZnOw supporting two-dimensional BNNSs. The results showed that the compressive strength, modulus and Vickers hardness of the scaffolds with incorporation of 1 wt% BNNSs and 7 wt% T-ZnOw together were about 96.15%, 32.86% and 357.19% higher than that of the PLLA scaffolds, respectively. This might be due to the effect of the pull out and bridging of BNNSs and T-ZnOw as well as the crack deflection, facilitating the formation of effective stress transfer between the reinforcement phases and the matrix. Furthermore, incorporation of BNNSs and T-ZnOw together into PLLA scaffolds was beneficial for attachment and viability of MG-63 cells. More importantly, the scaffolds significantly increased proliferation and promoted osteogenic differentiation of human bone marrow mesenchymal stem cells (hBMSCs). The enhanced mechanical and biological properties provide the potentials of PLLA/BNNSs/T-ZnOw scaffolds for the application into bone tissue engineering.

A Multimaterial Scaffold With Tunable Properties: Toward Bone Tissue Repair

“…The four diffraction peaks (2θ = 18.7°, 20.7°, 22.8°, and 28.7°) were corresponded to PEEK,9 and the characteristic peaks for both PLLA (2θ = 16.3°)10 and β‐TCP (2θ = 25.7°, 27.7°, 31.1°, and 34.3°)11 were presented, suggesting the presence of both PLLA and β‐TCP in the mixture powders. The PLLA powders and β‐TCP powders were uniformly dispersed throughout the PEEK matrix (Figure S1, Supporting Information).…”

An nMgO containing scaffold: Antibacterial activity, degradation properties and cell responses

“…Five formulations of PHBV/nMgO powders containing 0, 1, 3, 5 and 7 wt% nMgO were prepared mainly through the following procedures[ 21 ]: (a) weighing certain amounts of PHBV and nMgO powders according to the designed formulations, and adding them into two beakers containing certain amounts of absolute ethyl alcohol, respectively, followed by magnetically stirring the two solutions for 30 min, respectively; (b) adding the nMgO solution into the PHBV solution, and magnetically stirring the mixed solution for 30 min, followed by ultrasonically dispersing for 30 min; (c) filtering the mixed solution to obtain the mixed powders; (d) drying the mixed powders in vacuum drying oven at 60 °C for 24 h; (e) mechanically milling the dried powders with planetary ball mill for 2 h, and finally obtaining the PHBV/nMgO powders.…”

Antibacterial Capability, Physicochemical Properties, and Biocompatibility of nTiO2 Incorporated Polymeric Scaffolds

“…The improvements were owing to the reinforcement effect and uniformly-dispersed nTiO 2 . Noted that tensile strength and modulus would increase with inorganic filler contents were common in polymeric matrix [ 42 , 43 , 44 ]. However, when nTiO 2 were excessive, the variation tendency of mechanical properties started to reverse.…”