Space exploration plans are becoming increasingly complex as public agencies and private companies target deep-space locations, such as cislunar space and beyond, which require long-duration missions and many supporting systems and payloads. Optimizing multimission exploration campaigns is challenging due to the large number of required launches as well as their sequencing and compatibility requirements, making conventional space logistics formulations unscalable. To tackle this challenge, this paper proposes an alternative approach that leverages a two-level hierarchical optimization algorithm: an evolutionary algorithm is used to explore the campaign scheduling solution space, and each of the solutions is then evaluated using a time-expanded multicommodity flow mixed-integer linear program. A number of case studies, focusing on the Artemis lunar exploration program, demonstrate how the method can be used to analyze potential campaign architectures. The method enables a potential mission planner to study the sensitivity of a campaign to program-level parameters such as logistics vehicle availability and performance, payload launch windows, and in situ resource utilization infrastructure efficiency.